New advances in endocrine hypertension: from genes to biomarkers

Fernandes-Rosa, Fábio Luiz; Boulkroun, Sheerazed; Fedlaoui, Bakhta; Hureaux, Marguerite; Travers-Allard, Simon; Drossart, Tom; Favier, Judith; Zennaro, Maria‐Christina

doi:10.1016/j.kint.2022.12.021

Cited by 16 publications

(7 citation statements)

References 165 publications

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“…Additionally, the entire RAAS components can be found in the brain and may exhibit dysfunctional activity in various pathological conditions, including EH. In this context, the HSD11B2 gene, responsible for cortisol regulation, may experience suppression due to promoter hypermethylation, resulting in abnormal cortisol levels and the onset of EH ( 64 ). Studies in hypertensive rat models have further indicated a direct association between hypertension and hypermethylation of HSD11B2 ( 65 ).…”

Section: Interaction Between Epigenetics and Hypertensionmentioning

confidence: 99%

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Karabaeva,

Vochshenkova,

Mussin

et al. 2024

Front. Endocrinol.

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Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM.

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Section: Interaction Between Epigenetics and Hypertensionmentioning

confidence: 99%

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Karabaeva,

Vochshenkova,

Mussin

et al. 2024

Front. Endocrinol.

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“…The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that belongs to the nuclear receptor family, which arose in multicellular animals along with other vertebrate steroid receptors: the glucocorticoid receptor (GR), progesterone receptor (PR), androgen receptor (AR) and estrogen receptor (ER) [1][2][3][4][5][6]. The classical function of the MR in humans and other terrestrial vertebrates is to maintain electrolyte balance by regulating sodium and potassium transport in epithelial cells in the kidney and colon [7][8][9][10][11][12]. In addition, the MR also has important physiological functions in many other tissues, including brain, heart, skin and lungs [11,[13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone

Zhang,

Baker

2024

Preprint

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Due to alternative splicing in the DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW). Human MRs also contain mutations at two sites, codons 180 and 241, in the amino terminal domain (NTD). Together, there are five human MR genes in GenBank. Human MR-984, which was cloned in 1987, has been extensively studied. Human MR-988, cloned in 1995, contains KCSW in its DBD. Neither this human MR-988 nor the other human MR-988 genes have been studied for their response to aldosterone and other corticosteroids. Here, we report that transcriptional activation of human MR-988 by aldosterone is increased by about 50% compared to activation of human MR-984 in HEK293 cells transfected with the TAT3 promoter, while the half-maximal response (EC50) is similar for aldosterone activation of MR-984 and MR-988. The physiological responses in humans with MR genes containing KCSW and with differences in the NTD warrant investigation.

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“…Among pediatric hypertension cases, 50% are due to secondary causes, with endocrine hypertension comprising up to 6% [3]. Aside from obesityrelated hypertension, the primary endocrine disorders that cause hypertension in children are adrenal diseases characterized by an overproduction of catecholamines, glucocorticoids, and mineralocorticoids [4]. Non-adrenal endocrine disorders such as excess growth hormone, thyroid dysfunction, and hyperparathyroidism also lead to hypertension [4].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Endocrine Hypertension Related to the Adrenal Glands

Kim,

Kim

2023

Ewha Med J

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Endocrine causes of pediatric hypertension are relatively rare but important because of their distinct treatment options. Adrenal diseases accompanied by an excess of mineralocorticoids, glucocorticoids, and catecholamines are major causes of endocrine hypertension. Typical causes of mineralocorticoidrelated hypertension include primary aldosteronism, congenital adrenal hyperplasia (11β-and 17 α-hydroxylase deficiencies), and apparent mineralocorticoid excess. Cushing syndrome and pheochromocytoma/paraganglioma are the primary causes of glucocorticoid-and catecholaminerelated hypertension, respectively. This review provides an overview of the diagnostic evaluations, including hormonal assays and imaging studies, used to identify the underlying causes of pediatric endocrine hypertension, focusing on adrenal disorders. It presents details regarding the major adrenal disorders and recommended therapeutic approaches, emphasizing the importance of early detection and disease-specific management to prevent cardiovascular and metabolic complications in affected children.

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New advances in endocrine hypertension: from genes to biomarkers

Cited by 16 publications

References 165 publications

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone

Pediatric Endocrine Hypertension Related to the Adrenal Glands

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