Nuclear Magnetic Resonance 2020
DOI: 10.5772/intechopen.90263
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New Advances in Fast Methods of 2D NMR Experiments

Abstract: Although nuclear magnetic resonance spectroscopy is a potent analytical tool for identification, quantification, and structural elucidation, it suffers from inherently low sensitivity limitations. This chapter focuses on recently reported methods that enable quick acquisition of NMR spectra, as well as new methods of faster, efficient, and informative two-dimensional (2D) NMR methods. Fast and efficient data acquisition has risen in response to an increasing need to investigate chemical and biological processe… Show more

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Cited by 9 publications
(14 citation statements)
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“…From another perspective, one can further optimize the process of obtaining spectra by using different methods of measurements. One of these, called SOFAST, helps to reduce the delay between scans resulting in lowering acquisition time for 2D experiments such as HMQC utilizing 1 H, 15 N or 1 H, 13 C [ 117 , 446 , 447 ]. The basic principle of this method is to use selective 1 H pulses that will excite only a small portion of the available nuclei pool, while the unperturbed spins provide a magnetization “heat sink” thus improving the spin-lattice relaxation (T 1 ) rate via dipolar interactions [ 446 ].…”
Section: Final Remarksmentioning
confidence: 99%
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“…From another perspective, one can further optimize the process of obtaining spectra by using different methods of measurements. One of these, called SOFAST, helps to reduce the delay between scans resulting in lowering acquisition time for 2D experiments such as HMQC utilizing 1 H, 15 N or 1 H, 13 C [ 117 , 446 , 447 ]. The basic principle of this method is to use selective 1 H pulses that will excite only a small portion of the available nuclei pool, while the unperturbed spins provide a magnetization “heat sink” thus improving the spin-lattice relaxation (T 1 ) rate via dipolar interactions [ 446 ].…”
Section: Final Remarksmentioning
confidence: 99%
“…The basic principle of this method is to use selective 1 H pulses that will excite only a small portion of the available nuclei pool, while the unperturbed spins provide a magnetization “heat sink” thus improving the spin-lattice relaxation (T 1 ) rate via dipolar interactions [ 446 ]. These methods can be highly efficient when studying drug binding and molecular interactions [ 117 ].…”
Section: Final Remarksmentioning
confidence: 99%
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