New advances in optical coherence tomography for diagnostics of cervical neoplasia

Shakhova, Natalia M.; Gelikonov, Grigory V.; Kamensky, Vladislav A.; Kuranov, Roman V.; Sapozhnikova, Veronika V.; Turchin, Ilya V.; Gladkova, Natalia D.; Snopova, Ludmila B.; Kuznetzova, Irina A.

doi:10.1364/ecbo.2003.5140_138

Cited by 5 publications

(5 citation statements)

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“…This is expected to result in an improved diagnosis. Moreover, differentiating malignancies from benign tissue based on their different optical scattering properties is feasible as preliminary results (Levitz et al 2004, Shakhova et al 2002 seem to indicate. Again, this is also expected to result in improved diagnostic value of OCT systems.…”

Section: True-reflection Oct Imaging On An MC Simulated Heterogeneous...mentioning

confidence: 99%

Advanced modelling of optical coherence tomography systems

et al. 2004

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Analytical and numerical models for describing and understanding the light propagation in samples imaged by optical coherence tomography (OCT) systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle valid both for the single and multiple scattering regimes is reviewed. An advanced Monte Carlo model for calculating the OCT signal is also reviewed, and the validity of this model is shown through a mathematical proof based on the extended Huygens-Fresnel principle. Moreover, for the first time the model is verified experimentally. From the analytical model, an algorithm for enhancing OCT images is developed: the so-called true-reflection algorithm in which the OCT signal may be corrected for the attenuation caused by scattering. For the first time, the algorithm is demonstrated by using the Monte Carlo model as a numerical tissue phantom. Such algorithm holds promise for improving OCT imagery and to extend the possibility for functional imaging.

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Section: True-reflection Oct Imaging On An MC Simulated Heterogeneous...mentioning

confidence: 99%

Advanced modelling of optical coherence tomography systems

et al. 2004

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“…Optical methods are of great research interest for the evaluation of brain tissues in vivo [1] for representing: its structure (optical coherence tomography (OCT) [2][3][4], multiphoton microscopy [5] and multiphoton tomography [6]), chemical composition (Raman spectroscopy [7,8]) or metabolism (fluorescence diagnostics [9,10], including fluorescence lifetime imaging microscopy-FLIM [6]). The majority of the aforementioned methods undergo preclinical testing on animals or ex vivo human samples and then technical solutions are applied to integrate them into the surgical operating rooms [11,12].…”

Section: Introductionmentioning

confidence: 99%

Time-related ex vivo changes in the optical properties of normal brain tissues

et al. 2019

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The aim of the study was to observe time-related changes in the optical properties of normal brain tissues as measured using cross-polarization optical coherence tomography (CP OCT). 32 ex vivo tissue samples from 16 animals (rats) were monitored under different external conditions, over a period of 1 hour after excision, to measure time-related optical changes. It was found that the optical properties of white matter were quite stable over the time scales of the experiments, while the optical properties of the gray matter could change significantly. However, these changes could be minimized by using fresh sections from samples that had not been in contact with the air or the saline solution before the CP OCT examination. Such a protocol is suggested to significantly reduce optical changes in the brain tissue samples when ex vivo study is needed.

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“…According to (5), instead of NUFT (3), we multiply the 3D OCT spectrum by a phase mask with subsequent conventional discrete Fourier transform. Assume that parameters α and N 0 are specified so that their substitution into equation ( 3) for calculating the distribution with improved lateral resolution throughout the studied volume will correspond to the resolution in the plane of optimal focus.…”

Section: Reconstruction Of Oct Images With Improved Lateral Resolutionmentioning

confidence: 99%

“…It is widely used in biological and medical applications [1][2][3][4]. One of the promising ways of OCT development aimed at enhancing image informativity is an increase of resolution, lateral resolution in particular [5][6][7][8][9][10]. However, increasing lateral resolution of an OCT system by sharpening the scanning beam focal spot leads to an increase of diffraction divergence and to a corresponding decrease of focal depth.…”

Section: Introductionmentioning

confidence: 99%

Noniterative method of reconstruction optical coherence tomography images with improved lateral resolution in semitransparent media

Moiseev¹,

Gelikonov²,

Терпелов³

et al. 2013

Laser Phys. Lett.

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A method of OCT imaging with a resolution throughout the investigated volume equal to the resolution in the best-focused region is described. It is based on summation of three-dimensional scattered field distributions at the wavelengths determined by OCT source spectral decomposition. A method of finding parameters needed for algorithmic realization of the summation is also proposed. The proposed approaches are tested on several model media, including biological ones.

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New advances in optical coherence tomography for diagnostics of cervical neoplasia

Cited by 5 publications

References 0 publications

Advanced modelling of optical coherence tomography systems

Advanced modelling of optical coherence tomography systems

Time-related ex vivo changes in the optical properties of normal brain tissues

Noniterative method of reconstruction optical coherence tomography images with improved lateral resolution in semitransparent media

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