New advances in the diagnosis of primary aldosteronism

Shen, Hang; Xu, Zhixin; Li, Qifu

doi:10.1016/j.cdtm.2019.12.009

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Data analysis is mainly a combination of a priori knowledge and available statistical data, using probabilities to predict things [ 11 ]. This method is a fundamental approach in statistical modeling and is widely used in medical fields such as oncology, pathology, and high-throughput histology [ 12 ]. In this study, we investigated the diagnostic value of data analysis on the reliability of functional diagnostic tests for PA and studied the sensitivity and specificity of different post-dose plasma aldosterone cut points for the diagnosis of PA to provide a more rational basis for clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Reliability Analysis of a Functional Diagnostic Test for Primary Hyperaldosteronism Based on Data Analysis

Wang

Cai

2022

Computational Intelligence and Neuroscience

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Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, with a prevalence of 12–20% in the hypertensive population. To determine the characteristic function of a fuzzy concept based on the epidemiological data, clinical manifestations, and auxiliary examinations of PA, the essence is to select a suitable domain and determine the affiliation of each element in the domain. The aldosterone/renin ratio was proposed to increase the detection rate of PA, which has the shortcoming of a high underdiagnosis rate when relying only on clinical manifestations. However, there is no unified standard for the diagnostic cut point, and there are differences in testing methods and diagnostic cut point values for different populations, which require different laboratories to establish appropriate cut points according to different regional populations to improve the diagnostic accuracy. In this article, we analyzed the reliability of functional diagnostic tests for PA based on data analysis and compared the sensitivity and specificity of different plasma aldosterone cut points for the diagnosis of PA in the 40 mg kibbutz test. The results showed that when post-saline PAC and post-cato PAC were used to confirm the diagnosis of proaldosterone, respectively, there was a similar subject working area under the curve between SSST and CCT, 0.89 and 0.78, respectively, with no significant difference in the area under the curve between the two ( p = 0.546 ). Therefore, blood sodium and blood potassium have higher specificity and sensitivity than SUSPUP, but both are lower than ARR, and data analysis can be used as an auxiliary indicator for screening.

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Section: Introductionmentioning

confidence: 99%

Reliability Analysis of a Functional Diagnostic Test for Primary Hyperaldosteronism Based on Data Analysis

Wang

Cai

2022

Computational Intelligence and Neuroscience

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Development of a diagnostic model for pre-washout screening of primary aldosteronism

Wang,

Dong,

et al. 2024

J Endocrinol Invest

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Purpose Primary aldosteronism (PA) diagnosis is affected by antihypertensive drugs that are commonly taken by patients with suspected PA. In this study, we developed and validated a diagnostic model for screening PA without drug washout. Methods We retrospectively analyzed 1095 patients diagnosed with PA or essential hypertension. Patients were randomly grouped into training and validation sets at a 7:3 ratio. Baseline characteristics, plasma aldosterone concentration (PAC), and direct renin concentration (DRC) before and after drug washout were separately recorded, and the aldosterone-to-renin ratio (ARR) was calculated. Results PAC and ARR were higher and direct renin concentration was lower in patients with PA than in patients with essential hypertension. Furthermore, the differences in blood potassium and sodium concentrations and hypertension grades between the two groups were significant. Using the abbreviations potassium (P), ARR (A), PAC (P), sodium (S), and hypertension grade 3 (3), the model was named PAPS3. The PAPS3 model had a maximum score of 10, with the cutoff value assigned as 5.5; it showed high sensitivity and specificity for screening PA in patients who exhibit difficulty in tolerating drug washout. Conclusion PA screening remains crucial, and standard guidelines should be followed for patients to tolerate washout. The PAPS3 model offers an alternative to minimize risks and enhance diagnostic efficiency in PA for those facing washout challenges. Despite its high accuracy, further validation of this model is warranted through large-scale clinical studies.

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Numerical investigation of ice crystal melting characteristic and icing risk in an axial compressor

Jia

Yang

Zheng

et al. 2023

International Journal of Turbo &Amp; Jet-Engines

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The ingestion of ice crystals in aero-engine will cause engine surge, flameout, thrust loss, and even in-flight shutdown in the extreme cases, which seriously endanger the flight safety. In order to quantitatively investigate the ice crystal melting characteristic in the compressor, a method based on the compressor mean line flow was developed and validated. Results showed that the wet-bulb temperature increases as the temperature offset increases. The increase in temperature offset or decrease in particle size result in earlier or faster melting of the ice crystals in the low-pressure compressor. The rate of increase in melting ratio decreases with the increase of ice water content at the descent condition. The ambient temperature and ice crystal property are both the important factors affecting the icing risk in the compressor. Higher ambient temperature, smaller particle size or higher ice water content can increase the icing risk in the low-pressure compressor.

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New advances in the diagnosis of primary aldosteronism

Cited by 4 publications

References 26 publications

Reliability Analysis of a Functional Diagnostic Test for Primary Hyperaldosteronism Based on Data Analysis

Reliability Analysis of a Functional Diagnostic Test for Primary Hyperaldosteronism Based on Data Analysis

Development of a diagnostic model for pre-washout screening of primary aldosteronism

Numerical investigation of ice crystal melting characteristic and icing risk in an axial compressor

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