New Ag(I)−NHC/TBHP System for Oxidative Coupling of α‐Hydroxy Acetophenones with Amines: A Base‐Free and Efficient Synthesis of α‐Ketoamides in Water

Muqeed, Mohammad; Manchal, Ravinder; Botla, Vinayak; Azam, Mohammad; Vasam, Chandra Sekhar; Thirukovela, Narasimha Swamy

doi:10.1002/ajoc.202300356

Asian J Org Chem

2023

DOI: 10.1002/ajoc.202300356

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New Ag(I)−NHC/TBHP System for Oxidative Coupling of α‐Hydroxy Acetophenones with Amines: A Base‐Free and Efficient Synthesis of α‐Ketoamides in Water

Mohammad Muqeed,

Ravinder Manchal,

Vinayak Botla

et al.

Abstract: A base free and efficient tandem one‐pot α‐ketoamide bond formation via tert‐butyl hydroperoxide (TBHP) mediated oxidative coupling of α‐hydroxy acetophenones with primary and secondary amines under Ag(I)‐N‐Heterocyclic carbene (Ag(I)‐NHC) catalysis in eco‐friendly water was developed herein for the first time.

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Cited by 6 publications

References 100 publications

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tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations

Varala,

Seema,

Hussein

et al. 2024

ChemistrySelect

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Abstracttert‐Butyl hydroperoxide (tBuOOH, TBHP) is a commonly used hydroperoxide in many oxidation processes. The primary factors contributing to the increasing usefulness of TBHP include its affordability, eco‐friendliness, exceptional efficacy, and capacity to substitute harmful or rare heavy metal oxidants. In this sexennial update, we thoroughly and critically examined the most noteworthy applications of TBHP in C−H functionalization and heteroatom‐heteroatom bond formation reactions from 2018 till the present. The review has been subdivided based on the nature of the bonds being formed. The review focuses on the advantages and disadvantages of using synthetic organic transformations, as well as the breadth of their use and the underlying mechanisms involved.

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tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations

Varala,

Seema,

Hussein

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

IMesCuCl/TBHP system for aqueous oxidative amidation: Synthesis of new amide derivatives as EGFR targeting anti-breast cancer agents and computational studies

Sagam,

Azam,

Al-Resayes

et al. 2024

Journal of Molecular Structure

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Design and synthesis of some new imidazole-morpholine-1,2,4-oxadiazole hybrids as EGFR targeting in vitro anti-breast cancer agents

Kannekanti,

Nukala,

Bandari

et al. 2024

Journal of Molecular Structure

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New Ag(I)−NHC/TBHP System for Oxidative Coupling of α‐Hydroxy Acetophenones with Amines: A Base‐Free and Efficient Synthesis of α‐Ketoamides in Water

Cited by 6 publications

References 100 publications

tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations

tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations

IMesCuCl/TBHP system for aqueous oxidative amidation: Synthesis of new amide derivatives as EGFR targeting anti-breast cancer agents and computational studies

Design and synthesis of some new imidazole-morpholine-1,2,4-oxadiazole hybrids as EGFR targeting in vitro anti-breast cancer agents

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