New Alkaloids from Aconitum stapfianum

Yin, Tianpeng; Cai, Le; Liu, Ying; Fang, Yun-Shan; Li, Peng; Ding, Zhong‐Tao

doi:10.1007/s13659-015-0075-1

Cited by 13 publications

(4 citation statements)

References 18 publications

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“…Qin et al isolated five new NDAs from A. carmichaelii , carmichaenine A–E 27 – 31 [ 64 ], with characteristic 1-OH substitutions. Majusine D 32 from D. majus W. T. Wang and stapfianine A 33 from A. stapfianu were discovered as new C-19 NDAs [ 65 , 66 ] with 1-OH substitutions. Sharwuphinine B 34 was discovered from D. shawurense as one of the few quaternary C-19 NDAs ( Figure 4 ) [ 67 ].…”

Section: Norditerpenoid Alkaloid (Nda) Biodiversitymentioning

confidence: 99%

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects

Qasem

Rowan

Blagbrough

2022

IJMS

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There are famous examples of simple (e.g., hemlock, Conium maculatum L.) and complex (e.g., opium poppy, Papaver somniferum L., Papaveraceae) piperidine-alkaloid-containing plants. Many of these are highly poisonous, whilst pepper is well-known gastronomically, and several substituted piperidine alkaloids are therapeutically beneficial as a function of dose and mode of action. This review covers the taxonomy of the genera Aconitum, Delphinium, and the controversial Consolida. As part of studying the biodiversity of norditerpenoid alkaloids (NDAS), the majority of which possess an N-ethyl group, we also quantified the fragment occurrence count in the SciFinder database for NDA skeletons. The wide range of NDA biodiversity is also captured in a review of over 100 recently reported isolated alkaloids. Ring A substitution at position 1 is important to determine the NDA skeleton conformation. In this overview of naturally occurring highly oxygenated NDAs from traditional Aconitum and Delphinium plants, consideration is given to functional effect and to real functional evidence. Their high potential biological activity makes them useful candidate molecules for further investigation as lead compounds in the development of selective drugs.

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Section: Norditerpenoid Alkaloid (Nda) Biodiversitymentioning

confidence: 99%

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects

Qasem

Rowan

Blagbrough

2022

IJMS

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“…Due to the ester-group presence on C8 and sometimes on C14, they exhibit acute toxicity [ 1 , 3 , 8 ]. Several aconitines lack oxygenated groups on C15 and C6 ( 22–40 ) and rarely arrange a hydroxyl group on C1 as compound 22 [ 2 , 3 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Thawabteh

Lelario

et al. 2021

Molecules

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Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera. Corals, Xenia, Okinawan/Clavularia, Alcyonacea (soft corals) and marine sponges are rich sources of diterpenoids, despite the difficulty to access them and the lack of availability. Researchers have long been concerned with the potential beneficial or harmful effects of diterpenoid alkaloids due to their structural complexity, which accounts for their use as pharmaceuticals as well as their lousy reputation as toxic substances. Compounds belonging to this unique and fascinating family of natural products exhibit a broad spectrum of biological activities. Some of these compounds are on the list of clinical drugs, while others act as incredibly potent neurotoxins. Despite numerous attempts to prepare synthetic products, this review only introduces the natural diterpenoid alkaloids, describing ‘compounds’ structures and classifications and their toxicity and bioactivity. The purpose of the review is to highlight some existing relationships between the presence of substituents in the structure of such molecules and their recognised bioactivity.

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“…Plants in the genus Aconitum of the family Ranuculaceae are abundant in C 19 -and C 20 -diterpene alkaloids with diverse structural scaffolds and important biological activities, which have long attracted scientists' attention from chemistry and pharmacology communities [1][2][3]. Aconitum tanguticum (Maxim.)…”

Section: Introductionmentioning

confidence: 99%

Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

Yan

Wei

et al. 2021

Nat. Prod. Bioprospect.

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Three new diterpene alkaloids, tangutidines A–C (1–3), and four known alkaloids (4–7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1–3) were obtained for the first time. The structures of 1–3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities. Graphic Abstract

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New Alkaloids from Aconitum stapfianum

Cited by 13 publications

References 18 publications

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

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