New amide alkaloid from the aerial part of Piper capense L.f. (Piperaceae)

Kaou, Ali Mohamed; Mahiou-Leddet, Valérie; Canlet, Cécile; Debrauwer, Laurent; Hutter, Sébastien; Azas, Nadine; Ollivier, Évelyne

doi:10.1016/j.fitote.2010.03.006

Cited by 30 publications

(15 citation statements)

References 12 publications

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“…2D NMR spectra (data not shown) led us to structure 3, which has been reported as piperchabamide A with chemical shift data matching ours [23]. Piperchabamide A 3 has only been reported from Piper chaba [23] and Piper capense [24], and this is the first report of any amides from Macropiper. Two other amides (4 and 5) purified from this kawakawa fruits extract showed unusual features in their NMR spectra and could not be matched to any known Piper amides [17,25].…”

Section: Resultssupporting

confidence: 63%

Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum

et al. 2015

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Cytotoxic amides have been isolated from the fruits of the endemic New Zealand medicinal plant kawakawa, Macropiper excelsum (Piperaceae). The main amide was piperchabamide A and this is the first report of this rare compound outside the genus Piper. Eleven other amides were purified including two new compounds with the unusual 3,4-dihydro-1(2H)-pyridinyl group. The new compounds were fully characterized by 2D NMR spectroscopy, which showed a slow exchange between two rotamers about the amide bond, and they were chemically synthesized. In view of the antitumor activity of the related piperlongumine, all of these amides plus four synthetic analogs were tested for cytotoxicity. The most active was the piperine homolog piperdardine, with an IC50 of 14 µM against HT 29 colon cancer cells.

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Section: Resultssupporting

confidence: 63%

Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum

et al. 2015

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“…Roots, seeds Seeds (21.72) Antiplasmodial: kaousine; Z-antiepilepsirine (Kaou et al, 2010) Piper guineense (Schum and Thonn) (6018/SRFC) Respiratory infections, female infertility, aphrodisiac (Noumi et al, 1998) (Soladoye et al, 1989;Ferry et al, 1974) Bark, leaves, fruits Bark (17.81) Rutaceae Fagara leprieuri (Guill and Perr) Engl (37632/HNC) Abdominal pain, asthma, appendicitis, toothache (Diniz et al, 2007), spice Bark, seeds Seeds (21.06) Cytotoxic: 3-hydroxy-1-methoxy-10-methyl-9-acridone; 1-hydroxy-3-methoxy-10-methyl-9-acridone (4), 1-hydroxy-2,3-dimethoxy-10-methyl-9-acridone (5), 1,3-dihydroxy-2-methoxy-10-methyl-9-acridone were found to be moderately active against lung carcinoma cells (A549), colorectal adenocarcinoma cells (DLD-1) and normal cells (WS1) (Ngoumfo et al, 2010) Fagara macrophylla Engl. (2716/SRFKcam) Colds and stomach-ache, fever.…”

Section: ) Olacaceaementioning

confidence: 99%

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

Kuete

Krusche

Youns

et al. 2011

Journal of Ethnopharmacology

170

106

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“…Chemistry studies of Piper species have led to the identiication of a variety of new chemical compounds belonging to diferent classes, including alkaloids [26], amides [27], chromenes [28], derivatives of benzoic acids [29], lignans, neolignans, propenyl phenols, terpenes, steroids, chalcones, diidrochalcones, lavones, lavanones, kavalactones, piperolides, ceramides, faty acids [5,10] and lavonoids [23,26].…”

Section: Piper Genusmentioning

confidence: 99%

Biological Properties of Essential Oils from the Piper Species of Brazil: A Review

Takeara¹,

Gonçalves²,

SantosAyres³

et al. 2017

Aromatic and Medicinal Plants - Back to Nature

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Piperaceae, a Latin name derived from Greek, which in turn originates from the Arabic word babary-black pepper, is considered one of the largest families of basal dicots, found in tropical and subtropical regions of both hemispheres. The species that belong to this family have a primarily pantropical distribution, predominantly herbaceous members, occurring in tropical Africa, tropical Asia, Central America and the Amazon region. The Piperaceae family includes ive genera: Piper, Peperomia, Manekia, Zippelia and Verhuellia.Brazil has about 500 species distributed in the Piper, Peperomia and Manekia genera. The Piper genus, the largest of the Piperaceae family, has about 4000 species. Within the Piper genus, about 260-450 species can be found in Brazil. Piper species have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica and Mexico. Pharmacological studies of Piper species point toward the vast potential of these plants to treat various diseases. Many of these species are biologically active and have shown antitumor, antimicrobial, antioxidant, insecticidal, antiinlammatory, antinociceptive, enzyme inhibitor, antiparasitic, antiplatelet, piscicide, allelopathic, antiophidic, anxiolytic, antidepressant, antidiabetic, hepatoprotective, amebicide and diuretic possibilities.

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New amide alkaloid from the aerial part of Piper capense L.f. (Piperaceae)

Cited by 30 publications

References 12 publications

Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum

Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

Biological Properties of Essential Oils from the Piper Species of Brazil: A Review

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