New and Efficient Bioactive Glass Compositions for Controlling Endodontic Pathogens

Correia, Bruna L.; Gomes, Ana T. P. C.; Noites, Rita; Ferreira, J.M.F.; Duarte, Ana Sofia

doi:10.3390/nano12091577

Cited by 9 publications

(3 citation statements)

References 51 publications

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“…The three compositions differed in terms of the content of SiO 2 , CaO, MgO, and CuO. In this study, it has emerged that two BG compositions can inhibit the growth of E. faecalis after 48 h of incubation, whereas all samples can reduce C. albicans survival [137]. By addressing the challenges associated with conventional biomaterials and enhancing their properties through nanotechnology, researchers aim to pave the way for more effective and biocompatible solutions in endodontics and dental tissue regeneration.…”

Section: Bioactive Glass Nanoparticlesmentioning

confidence: 92%

“…The integration of BG-NPs in dental materials holds significant potential for advancing regenerative endodontic therapies and improving long-term treatment outcomes. With this aim, Correira et al have tested three different bioactive glass compositions produced using the sol-gel method to understand which one was the best for removing pathogens responsible for tooth reinfections and to find long-term treatments [137]. The three compositions differed in terms of the content of SiO 2 , CaO, MgO, and CuO.…”

Section: Bioactive Glass Nanoparticlesmentioning

confidence: 99%

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Nanoparticles and Their Antibacterial Application in Endodontics

Capuano,

Amato,

Dell’Annunziata

et al. 2023

Antibiotics

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Root canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, the field of nanotechnology has emerged as a promising frontier with numerous biomedical applications. Among the most notable contributions of nanotechnology are nanoparticles, which possess antimicrobial, antifungal, and antiviral properties. Nanoparticles cause the destructuring of bacterial walls, increasing the permeability of the cell membrane, stimulating the generation of reactive oxygen species, and interrupting the replication of deoxyribonucleic acid through the controlled release of ions. Thus, they could revolutionize endodontics, obtaining superior results and guaranteeing a promising short- and long-term prognosis. Therefore, chitosan, silver, graphene, poly(lactic) co-glycolic acid, bioactive glass, mesoporous calcium silicate, hydroxyapatite, zirconia, glucose oxidase magnetic, copper, and zinc oxide nanoparticles in endodontic therapy have been investigated in the present review. The diversified antimicrobial mechanisms of action, the numerous applications, and the high degree of clinical safety could encourage the scientific community to adopt nanoparticles as potential drugs for the treatment of endodontic diseases, overcoming the limitations related to antibiotic resistance and eradication of the biofilm.

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Section: Bioactive Glass Nanoparticlesmentioning

confidence: 92%

Section: Bioactive Glass Nanoparticlesmentioning

confidence: 99%

Nanoparticles and Their Antibacterial Application in Endodontics

Capuano,

Amato,

Dell’Annunziata

et al. 2023

Antibiotics

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“…F-BG (~5% mol.%) synthesis routes based on the 45S5 [193,194], 60S [195] and 77S [196] formulations have been tested using, respectively, NaF, CaF or HF reagents. The bactericidal properties of the elements Zn, Cu, Sr, Ag, Mg and Li have been exploited for their incorporation in sol-gel synthesis by means of nitrate precursor salts for the formulations 45S5 [186,187], 58S [197] and 50S (50 M% SiO 2 ) [198]. The search for improvement in the mechanical properties of 45S5 and 58S sol-gel synthesis has been studied with the incorporation of Al(NO 3 ) 3 9H 2 O [199] and ZrO 2 [200] precursors, respectively.…”

Section: Compositions and Chemical Routesmentioning

confidence: 99%

Sol–Gel Technologies to Obtain Advanced Bioceramics for Dental Therapeutics

Song,

Segura-Egea,

Díaz-Cuenca

2023

Molecules

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The aim of this work is to review the application of bioceramic materials in the context of current regenerative dentistry therapies, focusing on the latest advances in the synthesis of advanced materials using the sol–gel methodology. Chemical synthesis, processing and therapeutic possibilities are discussed in a structured way, according to the three main types of ceramic materials used in regenerative dentistry: bioactive glasses and glass ceramics, calcium phosphates and calcium silicates. The morphology and chemical composition of these bioceramics play a crucial role in their biological properties and effectiveness in dental therapeutics. The goal is to understand their chemical, surface, mechanical and biological properties better and develop strategies to control their pore structure, shape, size and compositions. Over the past decades, bioceramic materials have provided excellent results in a wide variety of clinical applications related to hard tissue repair and regeneration. Characteristics, such as their similarity to the chemical composition of the mineral phase of bones and teeth, as well as the possibilities offered by the advances in nanotechnology, are driving the development of new biomimetic materials that are required in regenerative dentistry. The sol–gel technique is a method for producing synthetic bioceramics with high purity and homogeneity at the molecular scale and to control the surfaces, interfaces and porosity at the nanometric scale. The intrinsic nanoporosity of materials produced by the sol–gel technique correlates with the high specific surface area, reactivity and bioactivity of advanced bioceramics.

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