New and Emerging Pathogens in Canine Infectious Respiratory Disease

Priestnall, Simon L.; Mitchell, Judy A.; Walker, Caray A.; Erles, Kerstin; Brownlie, Joe

doi:10.1177/0300985813511130

Cited by 90 publications

(95 citation statements)

References 106 publications

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“…There is evidence that M. cynos could be a primary pathogen of CIRD (Priestnall et al, 2014). However, in the current study, using an IHC procedure which had successfully labelled M. cynos previously (Chvala et al, 2007) there was not a single case of M. cynos infection and only two cases in which mycoplasmas were identified.…”

Section: Discussioncontrasting

confidence: 67%

“…Over the last decade there has been a resurgence of interest in canine respiratory pathogens, which has been triggered by the ineffectiveness of vaccines at controlling respiratory disease outbreaks, especially within large dog populations like in kennels or animal shelters. Furthermore, infections with novel pathogens causing more severe clinical signs or fatalities have contributed to the impact of CIRD (Priestnall et al, 2014). CIRD is characterised by infections with viruses, mycoplasmas or Bordetella (B.)…”

mentioning

confidence: 99%

“…bronchiseptica which cause damage to the mucociliary clearance mechanism of the upper airways as well as primary lesions in the lung tissue. In addition, some pathogens, such as canine respiratory coronavirus (CRCoV), are suspected to interfere with the host's immune system and predispose the host to secondary bacterial colonisation and infection (Caswell and Williams, 2007;Ford, 2012;Priestnall et al, 2014).…”

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confidence: 99%

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Age-related presence of selected viral and bacterial pathogens in paraffin-embedded lung samples of dogs with pneumonia

Wöhrer

Spergser

Bagrinovschi

et al. 2016

Acta Veterinaria Hungarica

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The aim of this retrospective study was to detect selected pathogens in pneumonic lung tissue of dogs of different age groups by immunohistochemistry (IHC), in situ hybridisation (ISH) or polymerase chain reaction (PCR) in order to get information about their involvement in pneumonia formation. In archived formalin-fixed and paraffin wax-embedded lung samples from 68 cases with the clinical and histologic diagnosis of pneumonia the histological pattern of pneumonia was re-evaluated and the samples were further investigated for the following infectious agents: canine distemper virus (CDV), canine adenovirus type 2 (CAV-2), canine respiratory coronavirus (CRCoV), Bordetella (B.) bronchiseptica, Pasteurella (P.) multocida, Mycoplasma spp., and Pneumocystis spp. In 47.1% of the samples at least one of the featured respiratory pathogens was detected. In 31.3% of these positive samples more than one pathogen could be found. The correct detection of CDV had been achieved in ten out of eleven positive cases (90.9%) upon initial investigation, but the presence of bacterial pathogens, like B. bronchiseptica (10 cases) and P. multocida (17 cases) had been missed in all but one case. While CDV and CRCoV infections were exclusively found in dogs younger than one year, the vast majority of infections with P. multocida and B. bronchiseptica were both common either in dogs younger than 4 months or older than one year. Thus, this retrospective approach yielded valuable data on the presence, absence and prevalence of certain respiratory pathogens in dogs with pneumonia.

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Section: Discussioncontrasting

confidence: 67%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Age-related presence of selected viral and bacterial pathogens in paraffin-embedded lung samples of dogs with pneumonia

Wöhrer

Spergser

Bagrinovschi

et al. 2016

Acta Veterinaria Hungarica

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“…CCoV, first described by Binn et al (1974), can affect both domestic and wild dogs worldwide (Decaro and Buonavoglia, 2008;Priestnall et al, 2014). Mild disease or asymptomatic carriages are probably in many cases common outcomes of infection (Graham and Baric 2010).…”

Section: Introductionmentioning

confidence: 99%

Canine coronavirus infection in dogs in Turkey: Virologicaland serological evidence

Avcı

Bulut

Yapici

et al. 2016

IJAR

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In the present study, virological and serological investigations were performed to determine the presence and prevalence of Canine corona virus (CCoV) infection in dog population in Turkey. Sera samples were analyzed for specific antibodies against CCoV by indirect enzyme linked immunosorbent assay (i-ELISA) while leukocyte samples were inoculated onto monolayers of Madin Darby Canine Kidney permanent cell culture. The cells were examined for viral antigen by direct immunofluorescence (IF) test after third passage. CCoV seropositivity was found in 46 (24.46%) of 188 dogs by indirect ELISA while only one leukocyte sample (0.53%) was detected as antigen positive by IF. Seropositive and antigen identification results were considered as indication of infection. From the results of this study it can be concluded that CCoV infection is widespread in the Turkish dog population and the virus may be attributed to be one of the important viral agents in dogs. In conclusion diagnosis of CCoV is difficult because it can easily be mixed with respiratory, enteric and generalized infections by other viral, bacterial and parasitic agents, but diagnosis and the vaccine application are essential for the control and prevention of CCoV infections.

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“…14, 15 The emerging role of equine herpesvirus 5 in equine multinodular pulmonary fibrosis affects not only our understanding of this pathologically satisfying disease but other important and enigmatic fibrotic lung diseases that afflict humans and other animals. 18 And no story of veterinary infectious disease would be complete without a mind to swine influenza virus, for which unprecedented levels of gene trading create looming threats to both swine production and public health.…”

mentioning

confidence: 99%

The Intriguing Pathology of Infectious Diseases

Caswell

Callanan

2014

Vet Pathol

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This special issue seeks to blend the border between pathology and microbiology, exploring recent developments in the understanding and recognition of infectious diseases of domestic animals. The pathology and pathogenesis of animal infectious diseases is a fascinating world, and veterinary pathologists encounter the breadth of these conditions in the course of their routine activities. Pathogens of domestic animals are important: they lead to suffering and death, are responsible for lost production and performance, underlie the widespread use of antibiotics in veterinary medicine, and cause disease in humans. Pathology is a key tool in the diagnosis, understanding, and control of these diseases. From a more selfish perspective, the lesions and pathogenesis of infectious diseases hold an intrinsic fascination and were a defining motivation for many of us to have focused our careers on veterinary pathology or veterinary infectious diseases. That moment on the microscope when we notice syncytia and intracytoplasmic inclusions in a calf's lung arouses our natural curiosity of how bovine respiratory syncytial virus incites these lesions and how these lesions incite clinical disease.16

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New and Emerging Pathogens in Canine Infectious Respiratory Disease

Cited by 90 publications

References 106 publications

Age-related presence of selected viral and bacterial pathogens in paraffin-embedded lung samples of dogs with pneumonia

Age-related presence of selected viral and bacterial pathogens in paraffin-embedded lung samples of dogs with pneumonia

Canine coronavirus infection in dogs in Turkey: Virologicaland serological evidence

The Intriguing Pathology of Infectious Diseases

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