Agricultural production is more affected by the increasing changes in the planet's climate than industrial sectors. To this are added global economic and geopolitical aggravations affecting agro-industrial production. The article presents the results of a study of changes in the use of natural resources in agriculture in Russia and, in this regard, an analysis of possible directions in the implementation of the national economic program of food security. The solution of this problem is closely connected with the need to reform the practice of providing state assistance to agricultural enterprises in the near future. The essence of the necessary changes is that additional financial incentives should be provided for farms that adhere to socially useful areas of activity – the use of high-performance modern production technologies, its greening, lowering product sales prices, increasing its supplies to domestic and foreign markets. The article also examines the possibility of expanding the use of land, water and biological resources in connection with solving the problem of food security. One of the possible schemes for managing the agro-industrial complex at the national economic level is shown, taking into account the negative impact on its development of external factors due to globalization natural and economic changes.