New and potential properties, characteristics, and analytical methods of ferulic acid: A review

Marcato, D; Spagnol, Caroline Magnani; Salgado, Hérida Regina Nunes; Isaac, Vera Lúcia Borges; Corrêa, Marcos Antônio

doi:10.1590/s2175-97902020000118747

Cited by 16 publications

(7 citation statements)

References 46 publications

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“…From the eight phenolic compounds found in our phenolic fraction of the P. arabica extract, the highest component concentration was ferulic acid (3.992 mg/gm) with a retention time of 3.22 min, which may contribute to the high efficacy of the phenolic extract as a cytotoxic biological chemical on different cancer cell lines. 29 Research has indicated that ferulic acid induces cell death by decreasing the Bcl-2 and increasing the BAX gene expression or by upregulation of caspase-3 and cleaved caspase-9. 30 The highest component of the terpene fraction was campesterol (4.358 mg/gm), with a retention time of 11.5 min.…”

Section: Discussionmentioning

confidence: 99%

Assessing the cytotoxicity of phenolic and terpene fractions extracted from Iraqi Prunus arabica on AMJ13 and SK-GT-4 human cancer cell lines

Mahmood¹,

Abd²,

Kadhim³

2023

F1000Res

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Background: Breast and esophageal cancer are the most aggressive and prominent causes of death worldwide. In addition, these cancers showed resistance to current chemotherapy regimens with limited success rates and fatal outcomes. Recently many studies reported the significant cytotoxic effects of phenolic and terpene fractions extracted from various Prunus species against different cancer cell lines. As a result, it has a good chance to be tested as a complement or replacement for standard chemotherapies. Methods: The study aimed to evaluate the cytotoxicity of phenolic and terpene fractions extracted from Iraqi Prunus arabica on breast (AMJ13) and esophageal (SK-GT-4) cancer cell lines by using the MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide). Analysis using the Chou-Talalay method was performed to assess the synergistic effect between the extracted fractions and chemotherapeutic agent (docetaxel). Moreover, high-performance liquid chromatography (HPLC) analysis was conducted for the quantitative determination of different bioactive molecules of both phenolic and terpene fractions in the extract. Results: According to the findings, the treatment modalities significantly decreased cancer cell viability of AMJ13 and SK-GT-4 and had insignificant cytotoxicity on the normal cells (normal human fibroblast cell line) (all less than 50% cytotoxicity). Analysis with Chou-Talalay showed a strong synergism with docetaxel on both cancer cell lines (higher cytotoxicity even in low concentrations) and failed to induce cytotoxicity on the normal cells. Important flavonoid glycosides and terpenoids were detected by HPLC, in particularly, ferulic acid, catechin, chlorogenic acid, β-sitosterol, and campesterol. Conclusions: In conclusion, the extracted fractions selectively inhibited the proliferation of both cancer cell lines and showed minimal cytotoxicity on normal cells. These fractions could be naturally derived drugs for treating breast and esophageal cancers.

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Section: Discussionmentioning

confidence: 99%

Assessing the cytotoxicity of phenolic and terpene fractions extracted from Iraqi Prunus arabica on AMJ13 and SK-GT-4 human cancer cell lines

Mahmood¹,

Abd²,

Kadhim³

2023

F1000Res

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“…In addition, high levels of FA were found in the shoot after HVED treatment. Marcato et al [ 76 ] observed that FA can absorb UV radiation through the creation of phenoxy radicals, resulting in cis-trans isomerization. Based on this, it is possible that FA might have a role in UV protection.…”

Section: Discussionmentioning

confidence: 99%

Effects of High Voltage Electrical Discharge (HVED) on Endogenous Hormone and Polyphenol Profile in Wheat

Marček

Hamow

Janda

et al. 2023

Plants

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High voltage electrical discharge (HVED) is an eco-friendly low-cost method based on the creation of plasma-activated water (PAW) through the release of electrical discharge in water which results in the formation of reactive particles. Recent studies have reported that such novel plasma technologies promote germination and growth but their hormonal and metabolic background is still not known. In the present work, the HVED-induced hormonal and metabolic changes were studied during the germination of wheat seedlings. Hormonal changes including abscisic acid (ABA), gibberellic acids (GAs), indol acetic acid (IAA) and jasmonic acid (JA) and the polyphenol responses were detected in the early (2nd day) and late (5th day) germination phases of wheat as well as their redistribution in shoot and root. HVED treatment significantly stimulated germination and growth both in the shoot and root. The root early response to HVED involved the upregulation of ABA and increased phaseic and ferulic acid content, while the active form of gibberellic acid (GA1) was downregulated. In the later phase (5th day of germination), HVED had a stimulatory effect on the production of benzoic and salicylic acid. The shoot showed a different response: HVED induced the synthesis of JA_Le_Ile, an active form of JA, and provoked the biosynthesis of cinnamic, p-coumaric and caffeic acid in both phases of germination. Surprisingly, in 2-day-old shoots, HVED decreased the GA20 levels, being intermediate in the synthesis of bioactive gibberellins. These HVED-provoked metabolic changes indicated a stress-related response that could contribute to germination in wheat.

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“…Furthermore, ferulic acid can be obtained by organic synthesis to improve yield and reduce preparation times. One method of ferulic acid synthesis is the condensation reaction of Knoevenagel-Doebner vanillin with malonic acid using piperidine [18] or proline [19] as a catalyst and microwave-assisted reaction [19][20][21] Ferulic acid has a relative molecular weight of 194 g/mol, a melting point of 174 o C, poor stability in an aqueous solution, and is soluble in hot water, methanol, ethanol, and acetone [22]. Ferulic acid is relatively hydrophilic, with an apparent partition coefficient of 0.3753 at pH 3 and 0.489 at pH 10.…”

Section: Refmentioning

confidence: 99%

“…Combining the phenolic ring and unsaturated side chain causes a resonance-stabilized phenoxy radical. The resonance stabilization explains how ferulic acid has an effective antioxidant capacity [22]. It might provide more sites for free radicals to attack and prevent them from destroying the cell membrane [27].…”

Section: Refmentioning

confidence: 99%

Exploration of Ferulic Acid and Its Derivatives as Potent Anti-Tyrosinase: A Systematic Review

Alifah,

Jatmika,

Hayun

2023

Egypt. J. Chem.

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Tyrosinase is an enzyme that catalyzes melanin biosynthesis. Recently, it has become a popular target for developing cosmetics as a skin lightening or skin whitening agent, an anti-aging agent, an anti-wrinkle agent, and other therapeutics for skin disorders. Based on the previous reports, many compounds have been developed and designed to be tyrosinase inhibitors, including ferulic acid and cinnamic acid derivatives. However, until now, the use of these compounds in commercial cosmetic products has been limited. It may be due to chemical instability, lipophilicity, and poor efficacy. In this review, we assessed research studies to discuss the structure-activity of ferulic acid and its derivatives, which can contribute to their better efficacy as anti-tyrosinases. Either ferulic acid as a single compound or its hybridization with other cinnamic acid derivatives proved beneficial in designing tyrosinase inhibitors as active functional groups. The structure-activity of the phenyl ring's substituent improved inhibitory effects on monophenolase activity, especially the halogen substituent. In addition, the alkyl chain length and other functional groups linked, such as amide and acetyl groups, could alter the inhibitory properties, including hydrophobicity, to produce a more stable complex ligand-receptor.

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New and potential properties, characteristics, and analytical methods of ferulic acid: A review

Cited by 16 publications

References 46 publications

Assessing the cytotoxicity of phenolic and terpene fractions extracted from Iraqi Prunus arabica on AMJ13 and SK-GT-4 human cancer cell lines

Assessing the cytotoxicity of phenolic and terpene fractions extracted from Iraqi Prunus arabica on AMJ13 and SK-GT-4 human cancer cell lines

Effects of High Voltage Electrical Discharge (HVED) on Endogenous Hormone and Polyphenol Profile in Wheat

Exploration of Ferulic Acid and Its Derivatives as Potent Anti-Tyrosinase: A Systematic Review

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