New ¿- and ¿-synuclein immunopathological lesions in human brain

Surgucheva, Irina; Newell, Kathy L.; Burns, Jeffrey M.; Surguchov, Andrei

doi:10.1186/preaccept-8883277521360376

Cited by 18 publications

(21 citation statements)

References 32 publications

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“…Elevated levels of NFTs, neurotoxic Aβ peptides, and loss of neurons and synapses, result in brain atrophy. These are the main factors in the progression of AD, which can be classified as a conformational disease [2] because of the roles of naturally unfolded prone to aggregation proteins in its development [3,4]. Currently, basic researchers and pharmaceutical companies have put an enormous amount of effort and funds toward finding novel targets for pharmacological interventions for AD.…”

Section: Alzheimer's Disease (Ad) Is a Devastating Neurodegenerative mentioning

confidence: 99%

ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain

Surguchev

Surguchov

2020

Brain Sciences

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Identification of genetic markers of a human disease, which is generally sporadic, may become an essential tool for the investigation of its molecular mechanisms. The role of ABCA7 in Alzheimer’s disease (AD) was discovered less than ten years ago when meta-analyses provided evidence that rs3764650 is a new AD susceptibility locus. Recent research advances in this locus and new evidence regarding ABCA7 contribution to the AD pathogenesis brought a new understanding of the underlying mechanisms of this disorder. An interesting, up-to-date review article "ABCA7 and Pathogenic Pathways of Alzheimer’s Disease" by Aikawa et al. (2018), outlines the ABCA7 role in AD and summarizes new findings in this exciting area. ABC transporters or ATP-binding cassette transporters are a superfamily of proteins belonging to a cell transport system. Currently, members of the family are the focus of attention because of their central role in drug pharmacokinetics. Two recent findings are the reason why much attention is drawn to the ABCA7 family. First, is the biochemical data showing a role of ABCA7 in amyloid pathology. Second, genetic data identifying ABCA7 gene variants as loci responsible for the late-onset AD. These results point to the ABCA7 as a significant new contributor to the pathogenesis of AD.

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Section: Alzheimer's Disease (Ad) Is a Devastating Neurodegenerative mentioning

confidence: 99%

ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain

Surguchev

Surguchov

2020

Brain Sciences

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“…It also should be mentioned that based on a double‐labeling immunofluorescence study α‐syn‐positive doughnut‐shaped often ubiquitin‐positive structures were located in the GFAP‐positive, swollen processes of Bergmann glia of the cerebellum in DLB/PD and less in MSA . Furthermore, several types of oxidized‐γ‐syn positive astrocytes with different morphologies were reported in PD/DLB and also in controls . An interesting aspect of glial α‐syn immunoreactivity was highlighted by a study comparing different epitope‐retrieval methods in distinctly processed tissue: this revealed that in the normal human brain both oligodendroglia and astroglia show prominent α‐syn immunoreactivity detectable in vibratome sections using proteinase K and formic acid pretreatment .…”

Section: Pag In Non‐tauopathy Neurodegenerative Diseasesmentioning

confidence: 99%

Protein astrogliopathies in human neurodegenerative diseases and aging

2017

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Neurodegenerative diseases are characterized by progressive dysfunction and loss of neurons associated with depositions of pathologically altered proteins showing hierarchical involvement of brain regions. The role of astrocytes in the pathogenesis of neurodegenerative diseases is explored as contributors to neuronal degeneration or neuroprotection pathways, and also as potential mediators of the transcellular spreading of disease-associated proteins. Protein astrogliopathy (PAG), including deposition of amyloid-β, prion protein, tau, α-synuclein, and very rarely transactive response DNA-binding protein 43 (TDP-43) is not unprecedented or unusual in neurodegenerative diseases. Morphological characterization of PAG is considered, however, only for the neuropathological diagnosis and classification of tauopathies. Astrocytic tau pathology is seen in primary frontotemporal lobar degeneration (FTLD) associated with tau pathologies (FTLD-Tau), but also in the form of aging-related tau astrogliopathy (ARTAG). Importantly, ARTAG shares common features with primary FTLD-Tau as well as with the astroglial tau pathologies that are thought to be hallmarks of a brain injury related tauopathy known as chronic traumatic encephalopathy (CTE). Supported by experimental observations, the morphological variability of PAG might reflect distinct pathogenic involvement of different astrocytic populations. PAG might indicate astrocytic contribution to spreading or clearance of disease-associated proteins, however, this might lead to astrocytic dysfunction and eventually contribute to the degeneration of neurons. Here we review recent advances in understanding ARTAG and other related forms of PAG.

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“…The family of synuclein proteins contains α-synuclein (SNCA), β-synuclein (SNCB), and SNCG [ 6 ]. The previous 2 proteins are ubiquitously detected in both neuronal cells and presynaptic nerve terminals, where their main physiological functions are the regulation of synaptic levels of monoamine neurotransmitters through modulation of vesicular release [ 7 ]. These 2 proteins are considered to be important in certain neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, and dementia with Lewy bodies [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of γ-Synuclein as a Stage-Specific Marker in Bladder Cancer by Immunohistochemistry

Xing

2014

Med Sci Monit

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BackgroundPrevious studies have shown that the expression level of γ-synuclein (SNCG) is associated with progression of many different malignant tumors. In this study, we discuss and assess the prognostic ability of SNCG in bladder cancer.Material/MethodsMedical records (2005–2013) were retrospectively reviewed for the population of interest. SNCG expression was identified immunohistochemically from bladder cancer tissues of 113 bladder cancer patients. The survival rate was calculated by the Kaplan-Meier method. Cox proportional hazard regression model was used for analysis of predictors of bladder cancer.ResultsSNCG was overexpressed in bladder cancer tissues compared with the normal bladder tissues (p<0.0001). SNCG expression in bladder cancer tissue was strongly related to tumor stage. However, SNCG level was not a prognostic factor of survival.ConclusionsOur results demonstrate that SNCG is highly expressed in bladder cancer tissue and its expression is stage-specific, but it is not helpful for predicting outcome in bladder cancer patients.

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New ¿- and ¿-synuclein immunopathological lesions in human brain

Cited by 18 publications

References 32 publications

ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain

ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain

Protein astrogliopathies in human neurodegenerative diseases and aging

Identification of γ-Synuclein as a Stage-Specific Marker in Bladder Cancer by Immunohistochemistry

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