New Anti-HIV-1, Antimalarial, and Antifungal Compounds from <i>Terminalia bellerica</i>

Valsaraj, R.; Pushpangadan, P.; Smitt, Ulla Wagner; Adsersen, Anne; Christensen, S. Brøgger; Sittie, Archibald; Nyman, Ulf; Nielsen, Claus; Olsen, Carl Erik

doi:10.1021/np970010m

Cited by 142 publications

(79 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since many years, phenolic compounds became the subject of anti-infective research, due to their antibacterial, antifungal and antiviral activity [28][29][30][31]. They can have an effect on growth and metabolism of bacteria, activating or inhibit- lytic uremic syndrome.…”

Section: Antimicrobial Testmentioning

confidence: 99%

Biochemical Characteristics, Antimicrobial and Mutagenic Activity in Organically and Conventionally Produced Malus domestica, Annurca

Fratianni¹,

Sada²,

Cipriano³

et al. 2007

TOFSJ

View full text Add to dashboard Cite

Abstract:Total polyphenols content and a partial phenolics composition from pulp and peel of organically and conventionally produced Malus domestica, Annurca were investigated. Furthermore, the antimicrobial effect of these compounds against useful and pathogen microorganism was examined. Finally, their mutagenic activities were evaluated. Organically grown apples showed a greater content of polyphenols, both into the pulp and the peel. The distribution of polyphenols was different between the two types of fruit, the organic fruit showing a more concentration of them, mainly into the peel extracts. The antimicrobial activity was also different: the conventionally produced samples showed a good inhibitory effect against Bacillus cereus, the organic peel revealed in addition a good inhibitory effect against Escherichia coli 0157:07. The results demonstrated a probable relationship between the phenolic composition and distribution in the extracts and the antimicrobial effect. The Ames test did not reveal the presence of an evident mutagenic activity in the conventional extracts. The antimutagenic activity was more evident in the organic extracts.

show abstract

Section: Antimicrobial Testmentioning

confidence: 99%

Biochemical Characteristics, Antimicrobial and Mutagenic Activity in Organically and Conventionally Produced Malus domestica, Annurca

Fratianni¹,

Sada²,

Cipriano³

et al. 2007

TOFSJ

View full text Add to dashboard Cite

show abstract

“…The chemical shifts were recorded in ppm (δ units) in relation to TMS as an internal standard. Pulse conditions were as follows: for 1 H NMR, dwell time (DW) 149.600 µs, acquisition time (AQ) 3.985 s, number of transients (NS) 16, recycle delay (RD) 1.000 s; for 13 C NMR spectra, DW 31.400 µs, AQ 2.058 s, NS 1024, RD 2.000 s, decoupling multiple resonance method Waltz-16; and for the NOESY contour maps, DW 113.600 µs, AQ 0.233 s, NS 16, RD 2.000 s, mixing time 200 ms, time evolution 3 µs, TD 2048 (F 2 ) and 512 (F 1 ).…”

Section: Experimental Partmentioning

confidence: 99%

“…They are very important from the biological viewpoint, presenting anti-oxidant, antibacterial, antitumoral and anti-HIV activities [1][2][3] . These substances are found in complex mixtures mainly because of the fact they condense with proteins and sugars.…”

Section: Introductionmentioning

confidence: 99%

NMR investigation and theoretical calculations of the effect of solvent on the conformational analysis of 4',7-di-hydroxy-8-prenylflavan

Alcântara¹,

Teixeira²,

Silva³

et al. 2004

Quím. Nova

View full text Add to dashboard Cite

Recebido em 12/2/03; aceito em 10/11/03 NMR INVESTIGATION AND THEORETICAL CALCULATIONS OF THE EFFECT OF SOLVENT ON THE CONFORMA-TIONAL ANALYSIS OF 4',7-DI-HYDROXY-8-PRENYLFLAVAN. The NMR conformational study of 4',7-di-hydroxy-8-prenylflavan 1 was carried out in acetone-d6, DMSO-d6 and CDCl 3 which enabled the proposition of three conformations, namely 1a, 1b and 1c, differing in the position of the prenyl group. Geometry optimizations performed using AM1 method showed that 1a (∆H f = -86.2 kcal/mol) is as stable as 1b (∆H f = -85.1 kcal/mol) and 1c (∆H f = -85.4 kcal/mol). When the solvent was included, the calculations showed that the solute-solvent interactions could be explained either in the light of the electronic intermolecular delocalization or the electrostatic character between solute and solvent. Theoretical calculations (HF/6-31G*, DFT/BLYP/6-31G*, and DFT/B3LYP/6-31G*) showed that the combination of these types of interactions present in each solute-solvent system, dependent on the chemical properties of the solvent, lead to different spatial arrangements of the prenyl group, which in turn determined the conformation of 1.

show abstract

“…In a previous study, we examined the in vitro anti-plas- Gessler et al, 1994;Sohni et al, 1995;Valsaraj et al, 1997). Similarly, L. multiflora presents antibacterial and antiplasmodial activities (Valentin et al, 1995).…”

Section: Plant Extractsmentioning

confidence: 99%

Anti-Toxoplasmaactivity of vegetal extracts used in West African traditional medicine

Benoit‐Vical¹,

Santillana-Hayat

Kone-Bamba

et al. 2000

Parasite

View full text Add to dashboard Cite

Summary:Both Toxoplasma gondii and Plasmodium are Apicomplexan protozoa that share common metabolic pathways and potential drug targets. The objective of this study was to examine the antiToxoplasma activity of nine West African plants with known activity against P. falciparum. The extracts were obtained from parts of plant commonly used, by most traditional healers, in the form of infusion or as water decoction. The in vitro activity of plant extracts on T. gondii was assessed on MRC5 tissue cultures and was quantified by enzyme-linked immunoassay. Aqueous extracts from Vernonia colorata were found to be inhibitory for Toxoplasma growth at concentrations > 10 mg/L, with an IC50 of 16.3 mg/L. A ten-fold gain in activity was obtained when organic solvents such as dichloromethane, acetone or ethanol were used to extract V. colorata's active principles. These extracts were inhibitory at concentrations as low as 1 mg/L, with IC50 of 1.7, 2.6 and 2.9 mg/L for dichloromethane, acetone and ethanol extracts respectively. These results indicate a promising source of new anti-Toxop/asma drugs from V. colorata and African medicinal plants. KEY WORDS :Toxoplasma gondii, medicinal plant, ethnopharmacol ogy, Ivory Coast, in vitro. Résumé : ACTIVITÉ ANTI-TOXOPLASMOSE D'EXTRAITS VÉGÉTAUX UTILISÉS DANS LA MÉDECINE TRADITIONNELLE D'AFRIQUE DE L'OUEST

show abstract

New Anti-HIV-1, Antimalarial, and Antifungal Compounds from Terminalia bellerica

Cited by 142 publications

References 20 publications

Biochemical Characteristics, Antimicrobial and Mutagenic Activity in Organically and Conventionally Produced Malus domestica, Annurca

Biochemical Characteristics, Antimicrobial and Mutagenic Activity in Organically and Conventionally Produced Malus domestica, Annurca

NMR investigation and theoretical calculations of the effect of solvent on the conformational analysis of 4',7-di-hydroxy-8-prenylflavan

Anti-Toxoplasmaactivity of vegetal extracts used in West African traditional medicine

Contact Info

Product

Resources

About