2021
DOI: 10.3390/molecules26040814
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New Antiadhesive Hydrophobic Polysiloxanes

Abstract: Intrinsic hydrophobicity is the reason for efficient bacterial settlement and biofilm growth on silicone materials. Those unwelcomed phenomena may play an important role in pathogen transmission. We have proposed an approach towards the development of new anti-biofilm strategies that resulted in novel antimicrobial hydrophobic silicones. Those functionalized polysiloxanes grafted with side 2-(carboxymethylthioethyl)-, 2-(n-propylamidomethylthioethyl)- and 2-(mercaptoethylamidomethylthioethyl)- groups showed a … Show more

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Cited by 9 publications
(8 citation statements)
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“…The best antiadhesive action was detected for the CuHABH complex for both bacterial strains. This was confirmed in microscopic observations using fluorescence microscopy after DAPI staining [82] (Figure 9). The highest levels of RLU corresponding to organic matter and ATP were recorded for the DMSO solution.…”
Section: Antibiofilm Activitysupporting
confidence: 68%
See 1 more Smart Citation
“…The best antiadhesive action was detected for the CuHABH complex for both bacterial strains. This was confirmed in microscopic observations using fluorescence microscopy after DAPI staining [82] (Figure 9). The highest levels of RLU corresponding to organic matter and ATP were recorded for the DMSO solution.…”
Section: Antibiofilm Activitysupporting
confidence: 68%
“…The best antiadhesive action was detected for the CuHABH complex for both bacterial strains. This was confirmed in microscopic observations using fluorescence microscopy after DAPI staining [82] (Figure 9). [83].…”
Section: Antibiofilm Activitysupporting
confidence: 68%
“…These reactive groups interact via hydrogen bonding with other functional groups, allowing them to bond with the glass surface [ 26 , 27 , 28 ]. Glass as a carrier is less colonized than hydrophobic surfaces, so the colonization effect is usually obtained by strongly adhering microbial cells [ 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…Poly(dimethylsiloxane), e. g PDMS-based polymers, commonly known as silicones, are not inherently antibacterial. Additives such as catalysts, including platinum nanoparticles 6 , and other low molecular weight species incorporated between polymer chains or grafted onto the polymer backbone may give silicone antibacterial activity [7][8][9] . Low surface tension and, therefore, high hydrophobicity is reported to be one of the primary reasons PDMS is prone to protein adsorption and bacterial adhesion 10 .…”
Section: Introductionmentioning
confidence: 99%