New antiaxillary odour deodorant made with antimicrobial Ag‐zeolite (silver‐exchanged zeolite)

Abstract

The causative substances for axillary osmidrosis, which are often found in apocrine sweat, are the decomposed/denatured products of short-chain fatty acid and other biological metabolite compounds produced by axillary-resident bacteria. Conventional underarm deodorants suppress the process of odour production mostly by the following mechanism: (1) suppression of perspiration, (2) reduction in numbers of resident bacteria, (3) deodorization and (4) masking. The most important and effective method to reduce odour is to suppress the growth of resident bacteria with antimicrobials, which have several drawbacks, especially in their safety aspect. To solve these problems, we focused on Ag-zeolite (silver-exchanged zeolite) that hold stable Ag, an inorganic bactericidal agent, in its structure, and therefore, poses less risk in safety. Its bactericidal effect on skin-resident bacteria was found to be excellent and comparable with that of triclosan, a most frequently used organic antimicrobial in this product category. The dose-response study of Ag-zeolite powder spray (0-40 w/w%) using 39 volunteers revealed that 5-40 w/w% Ag-zeolite could show a sufficient antimicrobial effect against skin-resident bacteria. The comparison study using 0.2 w/w% triclosan as the control and 10 w/w% Ag-zeolite indicated that: (1) one application of the powder spray containing 10 w/w% Ag-zeolite could show a sufficient antimicrobial effect against the resident bacteria and its effect continued for 24 h, (2) a powder spray containing 0.2 w/w% triclosan was unable to show a sufficient antimicrobial effect, and (3) no adverse event was observed. These studies show that Ag-zeolite has a superior antimicrobial ability that is rarely found in conventional antimicrobials used in deodorant products and a strong antiaxillary odour deodorant ability because of its long-lasting effect. During clinical study, patch tests with humans and other clinical studies of this product showed no adverse events related to the treatment with the Ag-zeolite product.

Terminalia ferdinandiana Exell. Extracts inhibit the growth of body odour‐forming bacteria

“…Despite this, chronic triclosan exposure has been linked to a myriad of serious health problems . Furthermore, triclosan persists for a relatively short period and is rapidly inactivated . Therefore, there is a need to develop more effective antimicrobial deodorant components. Masking the malodour with other, more palatable aromas.…”

On the different growth conditions affecting silver antimicrobial efficacy on Listeria monocytogenes and Salmonella enterica

“…Apart from the medical field, silver is nowadays incorporated as the key component to control microbial proliferation in a wide variety of materials used in our daily life like textile clothing, coatings in home appliances and food related applications like water treatment units (Han et al, 2005) or a great variety of food-contact materials (Appendini and Hotchkiss, 2002;Bouwmeester et al, 2009;Simpson, 2003) (see Gupta and Silver, 1998;Li et al, 2008;Rai et al, 2009 for review). In most of these materials, the antimicrobial effect relies on the leaking of silver ions based on ion-exchange from mineral carriers, like montmorillonites, tobermorites and most predominantly zeolites (Busolo et al, 2010;Cowan et al, 2003;Galeano et al, 2003;Nakane et al, 2006). The versatility and cost-effectiveness of these materials have made silver the most widely used polymer additive for food applications (Appendini and Hotchkiss, 2002;Quintavalla and Vicini, 2002).…”

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

“…It remains to be determined if silver nanoparticles will be safe in patients in the long run. In the mean time, silver nanoparticles remain a hot item and these are incorporated in a number of products ranging from device coatings and wound dressings to commercially available deodorants and cosmetics [81,82].…”