New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties.

Abstract

An unidentified Streptomyces, tentatively designated as Strain H 1051-MY 10, was proved to produce viomycin and two new antibiotics. The new antibiotics were extracted from the cultured mycelia with acetone and transferred to ethyl acetate after acetone was removed in vacuo. The extracted antibiotics were separated into two components by alumina column chromatography and named carbazomycins A and B, because both antibiotics were proved to contain a carbazole nucleus. The molecular formulae of carbazomycins A and B were determined to be C16H17NO2 and C15H15NO2, respectively. Further, carbazomycin B was methylated with diazomethane to give carbazomycin A. Carbazomycins inhibited the growth of phytophathogenic fungi and further showed weak antibacterial and antiyeast activities. THE JOURNAL OF ANTIBIOTICS JULY

Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione

“…Carbazomycin alkaloids 1 – 8 were first isolated by Nakamura and his group from Streptoverticillium ehimense H 1051-MY10 [17–23] as shown in Figure 1. In addition, literature survey showed that carbazomycins A, B, C, and D have also been successfully synthesized [24–27].…”

Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

“…Carbomycines A and B have been found to be useful as antibacterial and antifungal agents [12,13]. It has been reported that pyridocarbazoles show marked anticancer and anti-HIV activities [14][15][16].…”

Total Synthesis of Carbazomycins A and B

“…[1][2][3][4][5][6] Among them, carbazomycins have a simple structure, but attractive biological activities. Especially, carbazomycins A and B, which were isolated from the extract of cultured mycelia of Streptoverticillium ehimensis strain H1051-MY10 [7][8][9] (Chart 1), show inhibitory activity against 5-lipoxygenase, and have weak antibacterial and antiyeast activities. Carbazomycin B is also active against malaria.…”