New Antibiotics for the Treatment of Acute Bacterial Skin and Soft Tissue Infections in Pediatrics

Abstract

Acute bacterial skin and soft tissue infections (aSSTIs) are a large group of diseases that can involve exclusively the skin or also the underlying subcutaneous tissues, fascia, or muscles. Despite differences in the localization and severity, all these diseases are due mainly to Gram-positive bacteria, especially Staphylococcus aureus and Streptococcus pyogenes. aSSTI incidence increased considerably in the early years of this century due to the emergence and diffusion of community-acquired methicillin-resistant S. aureus (CA-MRSA). Despite the availability of antibiotics effective against CA-MRSA, problems of resistance to these drugs and risks of significant adverse events have emerged. In this paper, the present knowledge on the potential role new antibiotics for the treatment of pediatric aSSTIs is discussed. The most recent molecules that have been licensed for the treatment of aSSTIs include ozenoxacin (OZ), ceftaroline fosamil (CF), dalbavancin (DA), oritavancin (OR), tedizolid (TD), delafloxacin (DL), and omadacycline (OM). However, only OZ and CF have been licensed for use in children with aSSTIs, although the superiority of these antibiotics to those routinely used for the treatment of aSSTIs should be further demonstrated. Waiting for additional studies, OZ and CF should be prescribed for aSSTI treatment in the presence of the potential failure of old molecules.

Influence of Extraction Solvent on the Phenolic Profile and Bioactivity of Two Achillea Species

“…These infectious microorganisms are mainly Escherichia coli [ 12 ], Salmonella sp. [ 13 ], and Staphylococcus aureus , a foodborne [ 14 ], skin [ 15 ], and soft tissue infection pathogen [ 16 ]. Due to the extensive use of antibiotics, both E. coli [ 17 ], and S. aureus [ 18 ] are common pathogens that have developed multiple drug resistances.…”

“…Petrol ether, 2 chloroform,3 ethanol,4 water,5 inflorescences,6 vegetative part,7 not detected, 8 p-hydroxybenzoic acid, 9 m-hydroybenzoic acid,10 2,3-dihydroxybenzoic acid, 11 salicylic acid,12 chlorogenic acid,13 caffeic acid, 14 p-coumaric acid,15 ferulic acid,16 rosmarinic acid. The values within one row followed by the same letter do not differ significantly after factorial ANOVA post hoc Newman-Keuls analysis at a significance level of p < 0.01.…”

Chemical Characterization and Antibacterial Activity of Essential Oil of Medicinal Plants from Eastern Serbia

“…Escherichia coli is the most dominant pathogen causing urinary tract infections [ 19 , 20 , 21 ] as well as foodborne illnesses [ 22 , 23 , 24 ], while Staphylococcus aureus is the most common cause for foodborne [ 25 , 26 ], skin and soft tissue infectious diseases [ 27 , 28 , 29 ]. However, over the past decade, the changing pattern of resistance in E. coli and S. aureus has emphasized the need for new antimicrobial agents [ 30 , 31 , 32 ].…”

Activity of Tedizolid and Comparator Agents Against Gram-positive Isolates Causing Skin and Skin Structure Infections in Pediatric Patients in United States Hospitals (2015–2019)

“…ABSSSI consist of a large spectrum of diseases, from those that impair the skin exclusively to those that involve deep skin structures, such as subcutaneous tissues, fascia and muscles, causing cellulitis, abscesses and wound or burn infections that may be life-threatening. 1,2 These infections are most frequently caused by gram-positive bacteria, mainly Staphylococcus aureus . 1 In this context, the emergence and dissemination of community-acquired methicillin-resistant S. aureus (CA-MRSA) drastically changed the epidemiology of SSSI and narrowed the available therapeutic options.…”

“…Among others, vancomycin can be nephrotoxic and requires drug-level monitoring, while linezolid can be associated with the development of myelosuppression. 1 In addition, antimicrobial dosing guidelines in children are inconsistent, most likely due to the lack of pharmacokinetic/pharmacodynamic (PK/PD) data in this population. 5…”