New antibiotics, trichopolyns A and B: Isolation and biological activity

Fuji, Kaoru; Fujita, Eiichi; Takaishi, Yoshihisa; Fujita, Tetsuro; Arita, Ikuo; Komatsu, Machiko; Hiratsuka, N

doi:10.1007/bf01944702

Cited by 32 publications

(14 citation statements)

References 7 publications

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“…Several leucinostatins isolated from Paecilomyces marquandii (Massee) Hughes, have been reported to display biological activities including antifungal activity against C. neoformans and Candida species [154]. Other natural products, including trichopolyns A and B from Trichoderma polysporum [155] and helioferins A and B, products of Mycogone rosea , inhibit C. albicans [156]. Histatins, produced by human salivary glands, are naturally occurring peptides that have shown several activities including antifungal effects against pathogens such as C. albicans and C. neoformans .…”

Section: Agents Exhibiting Antifungal Activity With Unknown Mechanismentioning

confidence: 99%

The Mechanistic Targets of Antifungal Agents: An Overview

Mazu¹,

Bricker²,

Flores‐Rozas³

et al. 2016

MRMC

168

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Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs, which if not treated appropriately, contribute to the mortality associated with their conditions. Several studies have indicated that the majority of HIV-positive patients contract fungal infections throughout the course of their disease. Similar observations have been made regarding the increased frequency of bone marrow and organ transplants, the use of antineoplastic agents, the excessive use of antibiotics, and the prolonged use of corticosteroids among others. In addition, several pathogenic fungi have developed resistance to current drugs. Together these have conspired to spur a need for developing new treatment options for OIs. To aid this effort, this article reviews the biological targets of current and emerging drugs and agents that act through these targets for the treatment of opportunistic fungal infections.

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Section: Agents Exhibiting Antifungal Activity With Unknown Mechanismentioning

confidence: 99%

The Mechanistic Targets of Antifungal Agents: An Overview

Mazu¹,

Bricker²,

Flores‐Rozas³

et al. 2016

MRMC

168

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“…Singer], has spread to many countries throughout the world. However, Trichoderma spp., such as T. harzianum and T. polysporum, often attack and kill shiitake mycelium in bedlogs (Arita, 1971;Komatsu, 1976) by producing antifungal substances (Fuji et al,1978) and mycolytic enzymes (Tokimoto, 1982;Kitamoto et at.,1984;Ulhoa and Perberdy,1992) that reduce fruiting body yield. On the other hand, shiitake are more or less able to resist a Trichoderma attack.…”

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confidence: 99%

“…T. polysporum was stationarily incubated in a semi-synthetic liquid medium containing casamino acids 2 g, glucose 20 g, KH2PO4 1.0 g, MgSO4.7H2O 0.5 g, CaCl2.2H2O 0.1 g, adenine hydrochloride 5.0 mg, thiamine hydrochloride 0.1 mg, and trace elements per liter of distilled water (Tokimoto, 1982). Trichopolyn, an antibiotic, was isolated from the filtrate by the method of Fuji et al (1978). Agar media containing the same nutrients as the semi-synthetic liquid medium were prepared with or without trichopolyn (5 ppm).…”

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confidence: 99%

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Establishing the Selection Method for the Lentinula edodes Strains Resistant to Trichoderma spp.

Tokimoto

Komatsu

Fukumasa-Nakai

1994

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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Trichoderma inoculation tests for cultures of 89 different shiitake (Lentinula edodes) strains showed that the resistance of shiitake in a wood-powder medium correlated positively to that in 28-month-old bedlogs when T. harzianum was inoculated. Mycelial growth rate of shiitake in an agar medium or in the wood-powder medium also was correlated with the resistance of shiitake bedlogs, although the interaction in the agar medium appeared to be irrelevant. The amount of damage to shiitake caused by T. harzianum had a positive correlation with that by T. polysporum both in the wood-powder medium and in bedlogs. Strains having a high wood-rotting ability in bedlogs tended to have the ability to reject Trichoderma in the wood-powder medium. The inhibition rates of shiitake mycelial growth by trichopolyn proved not to correlate to the rate of damage by T. polysporum.

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“…By the middle of the 1980s, it was generally recognized that most of the hitherto known peptaibol antibiotics and related, Aib-containing structures such as trichopolyns [72] [73], efrapeptins [74], elvapeptins [75], and hypelcins [76] [77] represent microheterogeneous mixtures.…”

Section: 3mentioning

confidence: 99%

Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing C^α‐Dialkylamino Acids?

Degenkolb

Brückner

2008

Chemistry & Biodiversity

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Fungi are generally regarded as a literally infinite resource of bioactive secondary metabolites displaying remarkable structural diversity. Research on a particular group of linear and cyclic peptide antibiotics comprehensively named peptaibiotics--as result of the abundance of the non-proteinogenic C(alpha)-dialkylated alpha-amino acids alpha-aminoisobutyric acid (Aib) and isovaline (Iva)--has been started 50 years ago. These peptides have gained constantly increasing interest because of their unique bioactivities and conformations. This review, reflecting the history of peptaibiotic research from 1958 to 2008, is focussed on introducing both the structural diversity and natural microheterogeneity of the peptaibiotics, as well as the biodiversity of their fungal producers. Recently introduced state-of-the-art methods for rapid screening and sequencing of peptaibiotics, such as peptaibiomics and intact-cell MALDI-TOF mass spectrometry, are discussed. Finally, future prospects in peptaibiotic research are presented. Owing to the ubiquity and biodiversity of the fungal producers in the biosphere, the discovery of a myriad of peptaibiotics within the next decade is predicted.

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New antibiotics, trichopolyns A and B: Isolation and biological activity

Cited by 32 publications

References 7 publications

The Mechanistic Targets of Antifungal Agents: An Overview

The Mechanistic Targets of Antifungal Agents: An Overview

Establishing the Selection Method for the Lentinula edodes Strains Resistant to Trichoderma spp.

Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing C^α‐Dialkylamino Acids?

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New antibiotics, trichopolyns A and B: Isolation and biological activity

Cited by 32 publications

References 7 publications

The Mechanistic Targets of Antifungal Agents: An Overview

The Mechanistic Targets of Antifungal Agents: An Overview

Establishing the Selection Method for the Lentinula edodes Strains Resistant to Trichoderma spp.

Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing Cα‐Dialkylamino Acids?

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Product

Resources

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Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing C^α‐Dialkylamino Acids?