New antileishmanial sesquiterpene coumarins from Ferula narthex Boiss

Bashir, Shumaila; Alam, Muhammad Waqar; Adhikari, Achyut; Shrestha, Ram Lal; Yousuf, Sammer; Ahmad, Bashir; Parveen, Shama; Aman, Akhtar; Choudhary, M. Iqbal

doi:10.1016/j.phytol.2014.04.009

Cited by 41 publications

(20 citation statements)

References 18 publications

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“…Compound 1 (Figure 1 ) was found to be a sesquiterpene coumarin. The detail spectroscopic data of compound 1 were already reported in our previous article (Bashir et al, 2014 ). All of the spectral data of compound 2 have molecular formula C24H30O4 was found to be unambiguously matched with the reported data for conferol, previously isolated from Ferula pallida (Su et al, 2000 ).…”

Section: Resultsmentioning

confidence: 91%

Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent

et al. 2016

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The main objective of cancer management with chemotherapy (anticancer drugs) is to kill the neoplastic (cancerous) cell instead of a normal healthy cell. The bioassay-guided isolation of two new sesquiterpene coumarins (compounds 1 and 2) have been carried out from Ferula narthex collected from Chitral, locally known as “Raw.” Anticancer activity of crude and all fractions have been carried out to prevent carcinogenesis by using MTT assay. The n-hexane fraction showed good activity with an IC50 value of 5.434 ± 0.249 μg/mL, followed by crude MeFn extract 7.317 ± 0.535 μg/mL, and CHCl3 fraction 9.613 ± 0.548 μg/mL. Compounds 1 and 2 were isolated from chloroform fraction. Among tested pure compounds, compound 1 showed good anticancer activity with IC50 value of 14.074 ± 0.414 μg/mL. PASS (Prediction of Activity Spectra) analysis of the compound 1 was carried out, in order to predicts their binding probability with anti-cancer target. As a results the compound 1 showed binding probability with human histone acetyltransferase with Pa (probability to be active) value of 0.303. The compound 1 was docked against human histone acetyltransferase (anti-cancer drug target) by using molecular docking simulations. Molecular docking results showed that compound 1 accommodate well in the anti-cancer drug target. Moreover the activity support cancer chemo preventive activity of different compounds isolated from the genus Ferula, in accordance with the previously reported anticancer activities of the genus.

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Section: Resultsmentioning

confidence: 91%

Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent

et al. 2016

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“…[33] Compounds 10 and 11 were isolated from the root of Zanthoxylum armatum. The structures were confirmed by 1 HNMR, 13 CNMR, ESI-MS, and high-resolution mass spectrometry. HPLC grade methanol was purchased from Merck (Darmstadt, Germany).…”

Section: Methodsmentioning

confidence: 83%

Fragmentation pathways of synthetic and naturally occurring coumarin derivatives by ion trap and quadrupole time‐of‐flight mass spectrometry

Liang

Xiao

2015

Rapid Comm Mass Spectrometry

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The fragmentation pathways of 11 coumarin derivatives are elucidated based on ITMS and QTOFMS spectral data. Differences in the structures of the heterocyclic rings and side-chain substituents strongly affect the fragmentation pathways of the coumarins. The present results will facilitate further research into the fragmentation pathways and structural characterization of these classes of compounds with diverse structures. Copyright © 2015 John Wiley & Sons, Ltd.

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“…The detail spectroscopic data of compound 1 and compound 2 were already reported in our previous article (Bashir et al, 2014). …”

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confidence: 81%

Corrigendum: Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent

et al. 2016

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New antileishmanial sesquiterpene coumarins from Ferula narthex Boiss

Cited by 41 publications

References 18 publications

Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent

Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent

Fragmentation pathways of synthetic and naturally occurring coumarin derivatives by ion trap and quadrupole time‐of‐flight mass spectrometry

Corrigendum: Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent

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