New Antimycotics in the Pipeline – For Ophthalmology Too?

Behrens–Baumann, W.

doi:10.1055/a-1478-4248

Cited by 1 publication

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“…interfering specifically with the synthesis of a fungal protein of the cell wall, namely mannoprotein representing an essential constituent, is in the pipeline for ophthalmologic use. It is well tolerated after oral as well as intravenous application because of the selective mechanism of action [46].…”

Section: Discussionmentioning

confidence: 99%

Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex

Schrecker¹,

Seitz

Berger

et al. 2021

JoF

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Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging.

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Section: Discussionmentioning

confidence: 99%