New antitumor antibiotics: 13-Methylaclacinomycin A and its derivatives.

Soga, Katsuyoshi; Furusho, Hirofumi; Mori, Shunro; Oki, Taikan

doi:10.7164/antibiotics.34.770

Cited by 15 publications

(6 citation statements)

References 3 publications

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“…The idea of genetic selection of starter unit is further strengthened by the generation of mutants of S. coeruleorubidus which produced feudomycins from acetate and butyrate starter units . Mutants of S. galilaeus (aclacinomycin producer) were also isolated that used isobutyrate as starter instead of the usual propionate (Soga et al, 1981). One might speculate that those mutations were in the dpsC-equivalent genes of those strains, i.e., the fidelity factor described herein.…”

Section: Significance Of the Resultsmentioning

confidence: 99%

“…Several strains known to produce anthracyclines using propionyl-CoA as starter have been mutated to produce anthracyclines with acetates used as starter molecules (Fujiwara et al, 1981a,b;Soga et al, 1981;Oki et al, 1981;Hoshino and Fujiwara, 1983). Included in these strains are S. galilaeus ATCC 31133 (Soga et al, 1981) and a mutant of the baumycin and daunorubicin-producing S. coeruleorubidus ME130-A4 .…”

Section: Figmentioning

confidence: 99%

“…Included in these strains are S. galilaeus ATCC 31133 (Soga et al, 1981) and a mutant of the baumycin and daunorubicin-producing S. coeruleorubidus ME130-A4 . Since we now know that S. galilaeus possesses a DpsC homologue similar to that in Streptomyces sp.…”

Section: Figmentioning

confidence: 99%

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The Product of dpsC Confers Starter Unit Fidelity upon the Daunorubicin Polyketide Synthase of Streptomyces sp. Strain C5

Rajgarhia

Priestley

Strohl

2001

Metabolic Engineering

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Section: Significance Of the Resultsmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

See 1 more Smart Citation

The Product of dpsC Confers Starter Unit Fidelity upon the Daunorubicin Polyketide Synthase of Streptomyces sp. Strain C5

Rajgarhia

Priestley

Strohl

2001

Metabolic Engineering

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“…Cinerubin A (275) belongs to the class of anthracycline antibiotics isolated from several Streptomyces sp. [407] . Cinerubin A (275) was found to be much more active than cinerubin B Escherichia coli, and multiple drug-resistant Staphylococcus aureus [404,408] .…”

Section: Cinerubin Bmentioning

confidence: 99%

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Ueda¹,

Hashimoto²,

Yamamura³

et al. 2011

J Antibiot

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“…Cinerubin A (275) belongs to the class of anthracycline antibiotics isolated from several Streptomyces sp. [407] . Cinerubin A ( 275) was found to be much more active than cinerubin B Escherichia coli, and multiple drug-resistant Staphylococcus aureus [404,408] .…”

Section: Cinerubin Amentioning

confidence: 99%

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Mahmoud¹

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sources of bioactive constituents, as most medicinal plants (~97%) have been totally investigated. So, many other natural sources were being taken into consideration, especially those located in marine habitats e.g. soft corals, sponges, jellyfishes, algae, and microorganisms. Microorganisms are living symbiotically or located in sediments and represent a huge source of diverse bioactive secondary metabolites. Such diversity increases the possibility of structural novelty as well as bioactivity.Penicillin (1), one of the first antibiotics from microorganisms, was discovered in 1928 by Fleming, showing a bactericidal activity against the Staphylococcus sp.For this great discovery, Fleming, Chian and Florey were honoured with the Nobel Prize in 1945 [7] . Since the discovery of penicillin (1) and mycophenolic acid (2) before [8] , microorganisms, especially bacteria, played an essential role in the production of antibiotics and other drugs for the treatment of current diseases [9, 10] . 7The systematic investigations of marine environment as sources of novel biologically active agents began intensively in the mid 1970s. Among the phyla in the oceans, bacteria, fungi, algae, sponges, coelenterates, sea hares, bryozoans, tunicates and nudibranchs have been studied [28,29] . There is, however, a continual increasing of the reported new compounds from marine sources since 1965 (Figure 1). Sponges followed by coelenterates were the most studied marine organisms. Since that time, 13Didemnin B (13), a depsipeptide, was isolated from the Caribbean tunicateTrididemnum solidum [34] , inhibiting the synthesis of RNA, DNA and proteins in various cancer cell lines. It shows anti-viral and immunosuppressive activities as well as being an effective agent in treatment of leukaemia and melanoma. However, due to its toxicity, it was withdrawn from phase II clinical trials [35,36] .Thiocoraline ( 14), a novel depsipeptide was isolated (1997) from the mycelial extract of the bacterium Micromonospora marina, associated with a marine soft coral in the Indian Ocean. Thiocoraline (14) showed potent cytotoxic activity at a nanomolar concentration against several tumor cell lines. It inhibits DNA polymerase [37,38] . It is currently in preclinical phase by PharmaMar.

show abstract

New antitumor antibiotics: 13-Methylaclacinomycin A and its derivatives.

Cited by 15 publications

References 3 publications

The Product of dpsC Confers Starter Unit Fidelity upon the Daunorubicin Polyketide Synthase of Streptomyces sp. Strain C5

The Product of dpsC Confers Starter Unit Fidelity upon the Daunorubicin Polyketide Synthase of Streptomyces sp. Strain C5

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

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