New antitumor antibiotics: Musettamycin and marcellomycin from bohemic acid complex.

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

“…According to database searches, it is a new compound, which was named cinerubin K. About 500 naturally occurring Anthracycline antibiotics were reported in the literature [61,105,410] , containing at least one sugar moiety. They are characterized by their antibacterial and antitumor activities, e.g cinerubins [411] , ciclamycins [412] , musettamycin [413] , pyrromycin [398] . Antibacterial and antifungal activities of the isolated compounds (267, 269, 271~273, 275 and 276) were semi-quantitatively determined using the agar diffusion method with 9 mm paper discs and 20 µg /disk.…”

Crystal Structures of SnoaL2 and AclR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide Antibiotics

“…Modifications at the C-1 position of the aglycone backbone are also found in the secondary metabolites of other Streptomyces strains. 1,11,12 The gene cluster described by Chung et al 13 (Genbank accession code AB008466) is derived from a strain that originally produced 1-hydroxylated cinerubins in addition to aclacinomycin (MA 144-M1ZATCC 31133). 14 However, the authors sequenced the cluster from a mutant strain, which only produces aklavinone, and which is deficient in 1-hydroxylation.…”

Antitumor activity at the molecular level: binding modes in anthracycline–dinucleotide complexes as determined by optical titration and magnetic circular dichroism

“…This inhibition arises from an intercalative binding mode (5) and it is known that daunomycin and adriamycin intercalate into double-stranded DNA, although these drugs do not show any requirement for a particular base at the intercalation site (1)(2)(3)(4)(5)(6).…”

“…Several other active materials belonging to this general class of compounds have recently been isolated, among which are aclacinomycin, 1, marcellomycin, 2, and carminomycin, 3 (2)(3)(4) (Fig. 1).…”