New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates

Li, Xingshu; Peng, Xiaohui; Zheng, Beiyao; Tang, Jilin; Zhao, Yuanyuan; Ke, Mei‐Rong; Huang, Jian‐Dong

doi:10.1039/c7sc05115h

Cited by 190 publications

(121 citation statements)

References 53 publications

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“…[25][26][27] Accordingly,photothermal therapy (PTT), which generally employs photothermal agents to convert light energy to heat, is aw idely investigated therapeutic modality for tumor hyperthermia ablation. [28][29][30][31] Therefore,p retreatment of atumor with mild photothermal heating is afavorable approach to minimize hypoxia, thus,m aking tumors more susceptible to PDT.…”

Section: Improving Blood Flow In Tumorsmentioning

confidence: 99%

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

et al. 2018

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Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.

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Section: Improving Blood Flow In Tumorsmentioning

confidence: 99%

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

et al. 2018

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“…Therefore, to prove the photothermal effect in vitro, HeLa cells were incubated with PPAIB or MnO 2 @PPAIB for 6 h and then irradiated with a 660 nm laser (500 mW cm −2 ). As shown in Figure b, the temperature change of cells incubated in the normal environment was more than 20 °C, while that of cells treated with cold water to eliminate the heat was negligible. The results demonstrated that both PPAIB and MnO 2 @PPAIB exhibited excellent photothermal effect in the cells.…”

Section: Resultsmentioning

confidence: 95%

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy

Zhao

Xie

Jun-gu

et al. 2019

Adv Healthcare Materials

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of tumor. [7][8][9] Thus, SPT could exhibit the synergistic effect of "1 + 1 > 2" in theory. However, the effect of PDT would be limi ted severely due to the hypoxic microen vironment in the tumor, leading to that the photothermal effect often dominates the therapy efficiency during the syner gistic therapy process. [10][11][12][13][14][15][16] Thus, tradi tional combination of PTT and PDT failed to fully perform the effect of synergistic phototherapy. Consequently, it is very urgent to develop novel SPT agents which can show the truly synergistic and even enhanced effects of PTT and PDT.Recent works indicated that MnO 2 is a versatile nanocarrier for anticancer treat ment. [13][14][15][16][17] MnO 2 nanostructures have been demonstrated to enhance the anti cancer efficiency through the following three approaches: (1) catalyzing H 2 O 2 to generate O 2 to relieve the hypoxic environ ment in the tumor and enhance the PDT effect, [17,18] (2) generating extra heat to improve the PTT efficiency under irradia tion, [10,21] and (3) reacting with glutathione to reduce the consumption of ROS and release the anticancer drug to enhance the synergistic therapy process. [19,20] Therefore, MnO 2 nanocarriers provide a new insight into design strategies for enhancement of SPT effect. Nevertheless, common strategies to utilize MnO 2 nanocarrier for improving the anticancer effects face with the problems of complicated structures and cumbersome preparation process, because the nanosystems usually contain MnO 2 nanocarrier with various morphologies, phototherapy agents, hydrophilic group, and even some functional groups such as protein and RNA. [21][22][23][24] Therefore, developing MnO 2 nanosystems with simple structures for enhancing the synergistic therapeutic effi ciency is urgent but challenging.In order to construct a simple MnO 2 based nanosystem to realize the truly synergistic and even enhanced effects of PTT and PDT, suitable phototherapeutic agents should be selected. Among numerous phototherapeutic agents, nearinfrared (NIR) azaBODIPY dyes, which exhibit both excellent photo thermal and photodynamic effects, were ideal SPT agent for further application in combination with MnO 2 . [25][26][27][28][29] In parallel, to avoid the complex structure and preparation process of the Recent studies indicate that the synergistic phototherapy (SPT) process can simultaneously generate heat for photothermal therapy (PTT) and singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT) to overcome the recurrence of tumors. However, the hypoxic environment in tumors seriously limits the therapeutic effect of the oxygen-dependent PDT, leading to the domination of PTT in the SPT process. Therefore, it is urgent to develop a novel SPT platform for overcoming hypoxia in tumors and improving the therapeutic effect of both PTT and PDT. In this work, a novel phototherapeutic platform based on a nanocomposite of aza-BODIPY/manganese dioxide (MnO 2 ) is developed via simple electrostatic self-assembly. In this design, MnO 2 nanosheets, which coul...

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“…Metal‐ion‐induced electron transfer and fluorescence quenching have been widely applied in photoelectric devices, sensors, and photothermal materials. Huang and co‐workers studied the photothermal behavior of phthalocyanines coordinated to different metal ions . Under the same laser‐irradiation conditions, zinc phthalocyanine PcC2 exhibits strong fluorescence but a low temperature increase regardless of the laser‐excitation wavelength, while copper phthalocyanine PcC1 shows a significant temperature increase (Δ T ≈40 °C) with nearly complete fluorescence quenching.…”

Section: Metal‐ion‐coordination Photothermal Effectsmentioning

confidence: 99%

Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

et al. 2019

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Supramolecular assemblies have been very successful in regulating the photothermal conversion efficiency of organic photothermal materials in a simple and flexible way, compared with conventional molecular synthesis. In these assemblies, it is the inherent physiochemical mechanism that determines the photothermal conversion, rather than the assembly strategy. This Minireview summarizes supramolecular photothermal effects, which refer to the unique features of supramolecular chemistry for regulating the photothermal conversion efficiency. Emphasis is placed on the mechanisms of how self‐assembly affects the photothermal performance. The supramolecular photothermal effects on various types of light‐harvesting species are discussed in detail. The timely interpretation of supramolecular photothermal effects is promising for the future design of the photothermal materials with high efficiency, precision, and multiple functionalities for a wide array of applications.

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New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates

Abstract: We for the first time demonstrate that diversified molecular tuning approaches are available to effectively tailor phthalocyanine dyes for PTT.

Cited by 190 publications

References 53 publications

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy

Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

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New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates

Abstract: We for the first time demonstrate that diversified molecular tuning approaches are available to effectively tailor phthalocyanine dyes for PTT.

Cited by 190 publications

References 53 publications

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO2 for Enhancing Tumor Synergistic Therapy

Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

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Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy