New applications of advanced instrumental techniques for the characterization of food allergenic proteins

Benedé, Sara; Lozano‐Ojalvo, Daniel; Cristóbal, Susana; Costa, Joana; D’Auria, Enza; Veličković, Tanja Ćirković; Garrido‐Arandia, María; Karakaya, Sibel; Mazzucchelli, Gabriel; Picariello, Gianluca; Romero-Sahagun, Alejandro; Villa, Caterina; Roncada, Paola; Molina, Elena

doi:10.1080/10408398.2021.1931806

Cited by 11 publications

(8 citation statements)

References 162 publications

(168 reference statements)

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“…A recent review has summarized the many instrumental techniques applied in several areas of the food allergy field [ 47 ]. Nonetheless, specific surface plasmon resonance (SPR) sensors have been just developed to detect casein and β-LG [ 48 ], and its potential application to human milk is undeniable.…”

Section: Resultsmentioning

confidence: 99%

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Franco

Fente

Sánchez

et al. 2022

Foods

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The functionality of breast milk in terms of immunity is well-known. Despite this, a significant proportion of breastfed infants exhibit sensitization to different potentially allergenic proteins and clinical reactivity (including anaphylaxis) early in life and before the introduction of complementary feeding for the first time. The potential induction of early oral tolerance to overcome early allergic sensitization through exposure to allergens in breast milk also remains controversial and not yet well-established. The objective of this scoping review is to provide a critical appraisal of knowledge about the content of cow’s milk antigens in human milk. The amount of dietary derived milk antigens found in human milk and the analytical methodologies used to detect and quantify these antigens, the allergic status of the mother, the stage of lactation, the time of sampling (before or after ingestion of food), and the impact of human milk allergen on the infant were the outcomes that were assessed. Allergy risk was explored in all reviewed studies and could help to better elucidate its role in the context of allergic disease development. According to the included literature, we can conclude that there are mainly fragments derived from bovine proteins in human milk, and the presence of potentially allergenic molecules is greater in the milk of mothers with an allergic tendency. A clear relationship between maternal diet and allergen content in breast milk could not be firmly concluded though. Also, infants receiving milk from human milk banks, where donor milk is pasteurized for preservation, may be subject to greater risk of allergy development, especially for β-lactoglobulin.

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Section: Resultsmentioning

confidence: 99%

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Franco

Fente

Sánchez

et al. 2022

Foods

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“…The mode of food antigen consumption may alter the allergenicity of food antigens (23,24). In many studies, the type of cooked food antigen is not taken into consideration when assessing the tolerogenicity of the antigen.…”

Section: Kinetics Of Food Antigens In Breast Milk and Mode Of Antigen...mentioning

confidence: 99%

“…Park et al (25) showed that both roasted and raw peanuts had the same allergenic components; however, the processing of peanuts influences the allergenicity of peanut proteins. Specifically, the boiling of peanuts was found to decrease their allergenicity through the loss of low-molecular-weight allergens into water (26), while the roasting of peanuts was found to increase their allergenicity through the formation of neoepitopes of the main peanut allergens Ara h1 and Ara h2 (23). Therefore, it is clear that not only the mode of cooking but also food matrix interactions play a role in the allergenicity of antigens.…”

Section: Kinetics Of Food Antigens In Breast Milk and Mode Of Antigen...mentioning

confidence: 99%

Characteristics of Exogenous Allergen in Breast Milk and Their Impact on Oral Tolerance Induction

et al. 2022

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Food allergy is a common health problem in childhood since its prevalence was estimated to range from 6. 5 to 24.6% in European countries. Recently, a lot of research has focused on the impact of breastfeeding on oral tolerance induction. Since it was found that breast milk contains immunologically active food antigens, it would be very helpful to clarify the factors of antigen shedding that promotes oral tolerance. This narrative review aimed to summarize the latest evidence from experimental and human studies regarding allergen characteristics in human milk that may influence oral tolerance induction. A literature search in PubMed, MEDLINE, and Google Scholar was conducted. The diet of the mother was found to have a direct impact on allergen amount in the breastmilk, while antigens had different kinetics in human milk between women and depending on the antigen. The mode of antigen consumption, such as the cooking of an antigen, may also affect the allergenicity of the antigen in human milk. The dose of the antigen in human milk is in the range of nanograms per milliliter; however, it was found to have a tolerogenic effect. Furthermore, the presence of antigen-specific immunoglobulins, forming immune complexes with antigens, was found more tolerogenic compared to free allergens in experimental studies, and this is related to the immune status of the mother. While examining available data, this review highlights gaps in knowledge regarding allergen characteristics that may influence oral tolerance.

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“…Other analytical technologies are under development, but with scarce commercial presence. These include surface plasmon resonance (SPR) [ 127 , 128 , 129 ] electrochemical affinity biosensors [ 130 ]; the use of MIPs [ 131 ], biosensors, and nanoparticles, such as gold, carbon, and graphene [ 132 ]; and fluorescence-based methodologies [ 133 ]. The use of biosensors is an appealing alternative to instrumental analysis in food control, although there are currently few, if any, commercial applications for allergen control.…”

Section: Food Allergensmentioning

confidence: 99%

Methodological Approaches for Monitoring Five Major Food Safety Hazards Affecting Food Production in the Galicia–Northern Portugal Euroregion

Rodríguez-Herrera

Cabado

Bodelón

et al. 2021

Foods

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The agri-food industry has historically determined the socioeconomic characteristics of Galicia and Northern Portugal, and it was recently identified as an area for collaboration in the Euroregion. In particular, there is a need for action to help to ensure the provision of safe and healthy foods by taking advantage of key enabling technologies. The goals of the FOODSENS project are aligned with this major objective, specifically with the development of biosensors able to monitor hazards relevant to the safety of food produced in the Euroregion. The present review addresses the state of the art of analytical methodologies and techniques—whether commercially available or in various stages of development—for monitoring food hazards, such as harmful algal blooms, mycotoxins, Listeria monocytogenes, allergens, and polycyclic aromatic hydrocarbons. We discuss the pros and cons of these methodologies and techniques and address lines of research for point-of-care detection. Accordingly, the development of miniaturized automated monitoring strategies is considered a priority in terms of health and economic interest, with a significant impact in several areas, such as food safety, water quality, pollution control, and public health. Finally, we present potential market opportunities that could result from the availability of rapid and reliable commercial methodologies.

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New applications of advanced instrumental techniques for the characterization of food allergenic proteins

Cited by 11 publications

References 162 publications

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Characteristics of Exogenous Allergen in Breast Milk and Their Impact on Oral Tolerance Induction

Methodological Approaches for Monitoring Five Major Food Safety Hazards Affecting Food Production in the Galicia–Northern Portugal Euroregion

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