New applications of nanoparticles in cardiovascular imaging

Sharma, Rakesh; Kwon, Soonjo

doi:10.1080/17458080601101176

Cited by 16 publications

(4 citation statements)

References 37 publications

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“…174 Other molecular imaging probes have also been combined with iron oxide nanoparticles to enable multimodal vascular imaging with enhanced resolution and sensitivity. [175][176][177][178] QDs are another class of inorganic nanoparticles that have undergone substantial research in vascular imaging. QDs are semiconductor nanocrystals (e.g., particles with a cadmium selenide core with a zinc sulfide shell) whose fluorescent properties vary with size and composition, and they are sufficiently electron dense to also allow electron microscopy.…”

Section: Incorporation Of Therapeutic Agents In Nanoparticles Withoutmentioning

confidence: 99%

Vascular Nanomedicine: Current Status, Opportunities, and Challenges

Sun

Gupta

2019

Semin Thromb Hemost

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The term “nanotechnology” was coined by Norio Taniguchi in the 1970s to describe the manipulation of materials at the nano (10−9) scale, and the term “nanomedicine” was put forward by Eric Drexler and Robert Freitas Jr. in the 1990s to signify the application of nanotechnology in medicine. Nanomedicine encompasses a variety of systems including nanoparticles, nanofibers, surface nano-patterning, nanoporous matrices, and nanoscale coatings. Of these, nanoparticle-based applications in drug formulations and delivery have emerged as the most utilized nanomedicine system. This review aims to present a comprehensive assessment of nanomedicine approaches in vascular diseases, emphasizing particle designs, therapeutic effects, and current state-of-the-art. The expected advantages of utilizing nanoparticles for drug delivery stem from the particle's ability to (1) protect the drug from plasma-induced deactivation; (2) optimize drug pharmacokinetics and biodistribution; (3) enhance drug delivery to the disease site via passive and active mechanisms; (4) modulate drug release mechanisms via diffusion, degradation, and other unique stimuli-triggered processes; and (5) biodegrade or get eliminated safely from the body. Several nanoparticle systems encapsulating a variety of payloads have shown these advantages in vascular drug delivery applications in preclinical evaluation. At the same time, new challenges have emerged regarding discrepancy between expected and actual fate of nanoparticles in vivo, manufacturing barriers of complex nanoparticle designs, and issues of toxicity and immune response, which have limited successful clinical translation of vascular nanomedicine systems. In this context, this review will discuss challenges and opportunities to advance the field of vascular nanomedicine.

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Section: Incorporation Of Therapeutic Agents In Nanoparticles Withoutmentioning

confidence: 99%

Vascular Nanomedicine: Current Status, Opportunities, and Challenges

Sun

Gupta

2019

Semin Thromb Hemost

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“…However, it requires the consideration of imaging localized nanoparticle concentrations independent of tissue depth and limited to the proton spins within the tissue area with distributed nanoparticles. The MRI measures the dephasing effect of nanoparticle fields on spin population [125][126][127]. An additional limit is that a MRI cannot measure the nanoparticle induced fields as a distance.…”

Section: Temperature Imaging By Mri In Hyperthermiamentioning

confidence: 99%

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Sharma¹,

Sharma²,

Chen³

2011

TONMJ

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Abstract:Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.

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“…Of special relevance are those based on the use of luminescent nanoparticles (LNPs) as contrast agents [9] [9]. Compared to other probes employed for cardiac imaging such as magnetic nanoparticles or radioactive tracers [13,14] [13,14], the use of LNPs allows the use of optical (non-ionizing) radiation and of costeffective imaging apparatus. LNPs have already been used for in vitro imaging of ventricular myocytes [10,15][10,15] and H9c2 myoblasts [16][16], common cell types in cardiac tissue.…”

Section: Introductionmentioning

confidence: 99%

Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots

et al. 2019

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Ag2S nanodots have already been demonstrated as promising near-infrared (NIR-II, 1.0-1.45 μm) emitting nanoprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the potential application of functionalized Ag2S nanodots for accurate imaging of damaged myocardium tissues after a myocardial infarction induced by either partial or global ischemia. Ag2S nanodots surface-functionalized with the angiotensin II peptide (ATII) have shown over 10-fold enhanced binding efficiency to Nano ResearchDOI (automatically inserted by the publisher)

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New applications of nanoparticles in cardiovascular imaging

Cited by 16 publications

References 37 publications

Vascular Nanomedicine: Current Status, Opportunities, and Challenges

Vascular Nanomedicine: Current Status, Opportunities, and Challenges

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots

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