New approach for quantification of left ventricular function from low-dose gated bloodpool SPECT: Validation and comparison with conventional methods in patients

Liu, Yi-Hwa; Fazzone-Chettiar, Ramesh; Sandoval, Veronica; Tsatkin, Vera; Miller, Edward J.; Sinusas, Albert J.

doi:10.1007/s12350-019-01823-8

Cited by 8 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 At present, conventional planar ERNA has recently gained less favor due to the growing concern of radiation exposure (740 MBq; 5.18 mSV) to patients. 13,14 As Giubbini et al 11 explain, planar imaging is limited by the overlap of different cardiac structures affecting the calculation of LVEF, especially in the presence of mitral regurgitation, the valvular function cannot be explored, and the volumes of heart chambers are only roughly determined. Though, when compared to planar image acquisition, SPECT ERNA acquired with high-sensitivity CZT cameras can be done with lower radiation dose, faster image acquisition time, and improved reproducibility.…”

Section: 65mentioning

confidence: 99%

“…Currently, ERNA is used to: (A) quantify left ventricular and right stroke volumes and ejection fractions in patients with moderate to severe tricuspid regurgitation, 19 (B) obtain measures of dyssynchrony to predict outcomes in heart failure patients, [20][21][22][23] (C) assess left ventricular function and mechanical dyssynchrony in patients with right ventricular outflow tract pacing and right ventricular apical pacing, 24 (D) study the accuracy of automated LVEF measurements in the presence of large perfusion defects in a myocardial infarction, in which the estimation of endocardial borders might be expected to be difficult because of reduced or absent counts, requiring some degree of extrapolation with a geometric model, 25,26 (E) evaluate left and right ventricular volumes and function in patients with left ventricular assist devices, 2 (F) analyze the left and right ventricular function after surgical repair of Tetralogy of Fallot, 27 (G) validate ( Table 2) the ventricular function assessment by other imaging techniques, 13,25,[28][29][30][31][32][33][34] and (H) analyze left and right ventricular function before lung transplant ( Figure 2). Furthermore, in oncologic patients treated with chemotherapy, ERNA is a good imaging technique to detect systolic dysfunction through left and right ventricular ejection fraction analysis.…”

Section: Journal Of Nuclear Cardiologyòmentioning

confidence: 99%

See 1 more Smart Citation

Equilibrium radionuclide angiography: Present and future

Romero-Farina

Aguadé-Bruix

2021

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

This editorial refers to the article published by Sachpekidis et al 1 titled 'Equilibrium radionuclide angiography (ERNA): intra-and interobserver repeatability and reproducibility in the assessment of cardiac systolic and diastolic function' on the Journal of Nuclear Cardiology. The objective of this study was to assess the intra-and interobserver agreement in assessing the systolic and diastolic function with ERNA. The authors analyzed thirty-two adults underwent baseline and repeat ERNA. An experienced and a trainee operator analyzed the data by assigning regions of interest manually, fully automatically, and semi-automatically. The Bland-Altman statistic was used to assess the repeatability (two different assessments of a single acquisition) and reproducibility (assessments of two different acquisitions). According to the obtained results, the Authors concluded that: 'A good repeatability but a moderate reproducibility was found in the assessment of the left ventricular ejection fraction (LVEF). Less good were the findings in the assessment of diastolic function. The results also depended on the software tool'.This article provides interesting information about the intra-and interobserver repeatability and reproducibility in the assessment of cardiac systolic and diastolic function. Despite the fact that in the conclusions of this study the authors say that ERNA has a moderate reproducibility in the assessment of the LVEF; ERNA continues to be one of the best imaging techniques for the analysis of ventricular function. The analysis of the variability in the measurements of a technique is complex and not only depends on of the intra-and interobserver variability, but of other variabilities that are not generally taken into account, such as the day-to-day variability of the phenomenon studied, the variability of the pathology, age, gender, etc. In addition to this research study, it has a very heterogeneous population (men = 20, women = 12, heart failure = 13, cardiotoxic chemotherapy = 12, different degree of systolic dysfunction) in a small (n = 31) number of patients. Table 1 shows the reproducibility, and inter-and intra-observer variations of ERNA according to different acquisition methodology to evaluate left and right ventricular function. 1-7 ERNA has a high reproducibility, very low inter-or intra-observer variability, and high precision; it has been shown to be accurate when compared to other modalities and has strong early data that demonstrated efficacy in guiding the safety of treatment regimens, and it continues to be widely used for routine clinical monitoring. 8 This information is consistent with the comments of Sachpekidis et al. 9 in a previous review. Haarmark et al 10 evaluated 463 subjects without diabetes, previous potentially cardiotoxic chemotherapy, known cardiovascular or pulmonary disease, by means of Cadmium Zinc Telluride (CZT) SPECT camera. They conclude that there are age-related changes in cardiac dimensions with age depending on gender, although with only

show abstract

Section: 65mentioning

confidence: 99%

Section: Journal Of Nuclear Cardiologyòmentioning

confidence: 99%

Equilibrium radionuclide angiography: Present and future

Romero-Farina

Aguadé-Bruix

2021

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

show abstract

“…Three-dimensional gated blood pool SPECT is similar to the previous method, but it has the potential to differentiate cardiac chambers better than planar radionuclide ventriculography. Automatic measurement of the LVEF by [ 99m Tc]gated blood-pool SPECT (GBPS) provides accurate segmental wall motion analysis and estimates the cavity volume in a single examination [54,55]. Nevertheless, there is a good agreement in the rough calculation of LVEF between MUGA and GBPS methods [56].…”

Section: Single-photon Emission Computed Tomography (Spect)mentioning

confidence: 99%

State-of-the-art modalities in cardio-oncology: insight from a nuclear medicine approach

et al. 2021

View full text Add to dashboard Cite

Cancer and cardiovascular disease are the most significant causes of morbidity and mortality worldwide. Although the cancer survival rate has increased due to improved treatment approaches, especially targeted therapy, some side effects such as cardiotoxicity decrease the efficiency of the clinical outcome. Radiation therapy and chemotherapy have a long-established history of potential cardiotoxic effects. A new multi-disciplinary and translational field known as cardio-oncology has been developed for the identification, prevention, and treatment of cardiovascular dysfunctions associated with cancer treatment approaches. One of the important tools for detecting and monitoring cardiotoxic effects is non-invasive nuclear cardiac imaging techniques. Cardiac nuclear imaging modalities especially recent findings positron emission tomography (PET) tracers have a quintessential role in the early detection of cardiovascular disorders. Moreover, comprehensive studies are required to investigate novel nuclear medicine treatment approaches such as peptide receptor radionuclide therapy (PRRT), fibroblast activation protein (FAP), and chemokine receptor (CXCR) targeting probes for possible cardiac side effects that play important roles in the treatment of malignancies.

show abstract

“…13,17,18 A similar finding was also recently reported for cardiac bloodpool imaging (Figure 1). 12,19 As a result of the new collimation systems, the count sensitivity of these CZT cameras is three to sevenfold higher than that of a conventional dual-head gamma camera. 16 This ratio in Figure 1.…”

mentioning

confidence: 99%

“…In the present issue of the Journal of Nuclear Cardiology, 19 a novel approach using gated bloodpool SPECT and a reduced radioactive dose is presented. The underlying rationale is that an integration of all LV short-axis slices in a 2D display, mimicking a left anterior oblique view, will allow reaching high levels of LV counts per pixel as well as high signal-to-noise ratios.…”

mentioning

confidence: 99%