New approach for the strategic control of gastrointestinal nematodes in grazed beef cattle during the growing phase in central Brazil

Heckler, Rafael Pereira; Borges, Dyego Gonçalves Lino; Vieira, M.C.; Conde, Mário Henrique; Green, M.; Amorim, Mikael Leal Cabral Menezes de; Echeverria, Jéssica Teles; Oliveira, T.L.; Moro, Elio; Onselen, Valter Joost van; Borges, Fernando de Almeida

doi:10.1016/j.vetpar.2016.03.010

Cited by 27 publications

(37 citation statements)

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“…Apesar do exposto, deve-se ressaltar que no presente estudo, em função dos animais terem sido alocados aos grupos de tratamentos de forma aleatória, 15 bezerros pertencentes ao grupo não tratado (controle -T01) não apre- É notório que o desmame predispõe os animais a uma situação de estresse, o que por sua vez poderá desencadear no aumento do grau de infecção por parasitos de um modo geral (Lima 2004, Mundt et al 2003, Lopes et al 2013, Philippe et al 2014, Heckler et al 2016. Entretanto, no presente estudo foi observada diminuição nas contagens de OoPG após o desmame dos animais.…”

Section: Discussionunclassified

Avaliação da eficácia da lasalocida e de alguns fatores epidemiológicos de Eimeria spp. parasitando bezerros Nelore mantidos em regime de pastejo

et al. 2017

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The main importance of eimeriosis in cattle is due to lower performance shown with the disease in its sub-clinical form. This study evaluated the efficacy of lasalocid used against Eimeria spp. parasitizing calves. We also evaluated the weight gain of calves submitted to different treatments and analyzed some epidemiological factors that might interfere with Eimeria infection; 288 calves were used in the study. The calves of treatment 1 received protein mineral salt in low consumption without lasalocid, while the calves of treatment 2 received protein mineral salt on low consumption with lasalocid, administered orally to 4 to 10-month-old calves. Harvest of feces and weight control was made on days 0 (before the start of the experiment), at weaning, and 30 and 60 days after weaning (DAW). Evaluation of some epidemiological factors which could be related to infection by Eimeria spp. of the calves, such as weaning, sex and time of year, were analyzed, taking into account the results regarding the 144 calves of the control group. Nine species of Eimeria were identified in descending order: E. brasiliensis, E. wyomingensis, E. bovis, E. canadian, E. zuernii, E. auburnensis, E. ellipsoidalis, E. pellita and E. cylindrica. Unexpectedly, decrease in parasite load could be observed after weaning. Even the farm did not adopt management measures aimed for greater productivity, as Artificial Insemination in Fixed Time, which in turn ends up with increase of the number of births and animal unit per hectare at a certain period of year, high parasitism of coccidia was diagnosed in calves of the control group. Oocyst counts per gram (OPG) of calves treated with lasalocid were significantly lower (P≤0.05) in the control group. The compound achieved ≥95% efficacy against the parasite in question. At the end of the study, calves fed lasalocid gained on average 7.2kg (p≤0.05) more than calves in the control group. For a farm that aims to sell calves soon after weaning, is recommended to start treatment with lasalocid, with the creep-feeding, from an age of three months on, since the weight gain calves treated with lasalocid was significantly (p=0.05) higher compared with the weight gain of the control group after five months of treatment. The difference in weight 1 Recebido em 15 de abril de 2016.Aceito para publicação em 30 de setembro de 2016.

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Section: Discussionunclassified

Avaliação da eficácia da lasalocida e de alguns fatores epidemiológicos de Eimeria spp. parasitando bezerros Nelore mantidos em regime de pastejo

et al. 2017

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“…Firstly, we performed a simulated financial evaluation of the six deworming protocols evaluated by Heckler et al (2016), based on the economic scenario from January 2015 to December 2017.…”

Section: Methodsmentioning

confidence: 99%

“…The Brazilian livestock production almost exclusively grass-fed associated with tropical characteristics, hot and humid summers and cold and dry winters, provides conditions for an all-yearround occurrence of gastrointestinal nematodes (GINs) in bovines (HECKLER et al, 2016), thereby negatively affecting animal reproduction and production performances, even that of their offspring (LOYACANO et al, 2002). These same epidemiological characteristics can be observed in other tropical humid regions, such as in northern Argentina (SUAREZ et al, 2018) and Tanzania (KEYYU et al, 2009), where Cooperia spp.…”

Section: Introductionmentioning

confidence: 99%

“…To this end, an alternative strategic control against GINs of beef cattle was proposed in Midwest Brazil (HECKLER et al, 2016). This new proposal aims to merge fixed cattle handling practices and GIN epidemiology described by Bianchin et al (1996).…”

Section: Introductionmentioning

confidence: 99%

“…This new proposal aims to merge fixed cattle handling practices and GIN epidemiology described by Bianchin et al (1996). That said, treatments should be performed in May, with FMD vaccination since parasitic loads in animals increase at the beginning of the dry period; in August, due to a nutritional and immunological deficit by reductions in forage quality during the dry season; and in November, seeking to reduce environmental contamination for the next (rainy) season hence coming years, in addition to merge with the second FMD vaccination (HECKLER et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Economic analysis of strategic control program (5, 8, 11) for gastrointestinal nematodes in grazing beef cattle during the growing phase in Central Brazil

Conde

Heckler

Borges

et al. 2019

SCA

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This study aimed to analyze economically different control protocols for beef cattle gastrointestinal nematodes in Brazil. Field study data previously published was used to compare three groups: 1) nondosed; 2) current deworming program with two doses -May and November; and 3) alternative strategic control program with three doses -May, August, and November. An economic sensitivity analysis was performed based on beef carcass price (BCP) variation, thus creating three economic scenarios: 1) more probable (M) using the mean BCP in the studied region; 2) optimistic (O) using the mean BCP plus standard deviation; and 3) pessimistic (P) using the mean BCP minus standard deviation. Stock valuation (SV), operational result (OP), and treatment differential (TD) were calculated for each scenario. Average BCP was US$ 2.93 kg -1 carcass (± US$ 0.27 kg -1 carcass). The mean annual cost of deworming per animal was US$ 5.43 and US$ 7.97 for protocols with two and three doses, respectively. The cost of anthelmintic treatment represented 0.63% and 0.74% of operating results, both in M scenario. TD ranged from 9.5% to 27.6% for the assessed protocols. Regardless of the scenario, the protocol with three annual dosages presented the highest SV and OP, which economically justifies its implementation in strategic control of gastrointestinal nematodes in grazing beef cattle in Central Brazil. These results also demonstrate the relevance of strategic anthelmintic treatments in weaned stocker calves in tropical and humid subtropical areas.

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Bioanalytical method development and validation of moxidectin in plasma by LC–MS/MS: Application to in vitro metabolism

Chhonker

Murry

2018

Biomedical Chromatography

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Moxidectin (MOX) has recently been approved by the US Food and Drug Administration for the treatment of river blindness in select populations. It is also being evaluated as an alternative for the use of ivermectin, widespread resistance to which is becoming a global health issue. Moreover, MOX is becoming increasingly used as a prophylactic antiparasitic in the cattle industry. In this study, we developed and validated an LC–MS/MS method of MOX in human, monkey and mouse plasma. The separation was achieved on an ACE C18 (50 × 3.0 mm, 3 μm) column with isocratic elution using 0.1% acetic acid and methanol–acetonitrile (1:1, v/v) as mobile phase. MOX was quantitated using MS/MS with an electrospray ionization source operating in negative multiple reaction monitoring mode. The multiple reaction monitoring precursor ion → product ion transitions for MOX and abamectin (IS) were m/z 638.40 → 236.30 and m/z 871.50 → 565.35 respectively. The MS/MS response was linear over the concentration range 0.1–1000 ng/mL in plasma with a correlation coefficient (r2) of 0.997 or better. The within‐ and between‐day precision (relative standard deviation, RSD) and accuracy were within the acceptable limits per US Food and Drug Administration guidelines. The method was successfully applied to an in vitro metabolic stability study of MOX.

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New approach for the strategic control of gastrointestinal nematodes in grazed beef cattle during the growing phase in central Brazil

Cited by 27 publications

References 27 publications

Avaliação da eficácia da lasalocida e de alguns fatores epidemiológicos de Eimeria spp. parasitando bezerros Nelore mantidos em regime de pastejo

Avaliação da eficácia da lasalocida e de alguns fatores epidemiológicos de Eimeria spp. parasitando bezerros Nelore mantidos em regime de pastejo

Economic analysis of strategic control program (5, 8, 11) for gastrointestinal nematodes in grazing beef cattle during the growing phase in Central Brazil

Bioanalytical method development and validation of moxidectin in plasma by LC–MS/MS: Application to in vitro metabolism

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