New Approaches and Biomarker Candidates for the Early Detection of Ovarian Cancer

Hossain, Khondker R.; Bermeo, Jonathan; Warton, Kristina; Valenzuela, Stella M.

doi:10.3389/fbioe.2022.819183

Cited by 7 publications

(6 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several researchers have examined the expression profiles of miRNAs in serum samples from individuals with EOC, with the goal of identifying biomarkers for the condition [30,32]. Although a specific study effectively identified certain circulating miRNAs consistently linked to epithelial ovarian cancer (EOC), there is a lack of consensus regarding the methodologies employed [32], and the costs associated with miRNA profiling are substantial [24]. Currently, there is no definitive biomarker available to predict the response to therapy, whether based on mRNA, protein, or DNA.…”

Section: Serum-based Eoc Biomarkersmentioning

confidence: 99%

“…However, these methods often lack the necessary sensitivity to detect proteins found in low concentrations, including CA125 and human epididymis protein 4 (HE4) [19,20,22]. The current approaches for investigating EOC biomarkers linked to exosomes in human serum include flow cytometry, protein microarray, diagnostic magnetic resonance, nanoplasmonic sensing technology, and microfluidics [24]. In recent years, multiplex immunoassay techniques have gained popularity for simultaneously detecting multiple combinations of EOC biomarkers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Kumar,

Kampan,

Abd Aziz

et al. 2023

Cancers

View full text Add to dashboard Cite

Epithelial Ovarian Cancer (EOC) is a leading cause of cancer-related deaths among women, mainly due to a lack of early detection and screening methods. Advanced immunoassay techniques, such as Luminex and proximity extension assay (PEA) technology, show promise in improving EOC detection by utilizing highly sensitive and specific multiplex panels to detect multiple combinations of biomarkers. However, these advanced immunoassay techniques have certain limitations, especially in validating the performance characteristics such as specificity, sensitivity, limit of detection (LOD), and dynamic range for each EOC biomarker within the panel. Implementing multiplexing in point-of-care (POC) biosensors can enhance EOC biomarker detection, with Surface Plasmon Resonance (SPR) being a versatile option among optical biosensors. There is no study on multiplex SPR biosensors specifically tailored for diagnosing EOC. Recent studies have shown promising results in the single detection of EOC biomarkers using SPR, with LOD for cancer antigen 125 (CA125) at 0.01 U/mL−1 and human epididymis protein 4 (HE4) at 1pM. This study proposes a potential roadmap for scientists and engineers in academia and industry to develop a cost effective yet highly efficient SPR biosensor platform for detecting EOC.

show abstract

Section: Serum-based Eoc Biomarkersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Kumar,

Kampan,

Abd Aziz

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…Besides their promising potential in improving organ survival and transplant success rates, evidence has revealed that exosomes can act as nanoscale biological warehouses that transfer a wide range of biomolecules from their originated cells into other parts. Depending on existing disease states, exosomes can carry disorder-specific biomarkers that can allow them to be used as early-stage prognosis platforms (Hossain et al, 2022;Hsu et al, 2022;Hu et al, 2022;Yi et al, 2022). However, diseaseassociated biomarkers and proteins carried by exosomes can also partially impair normal physiological signaling pathways and speed up metastasis and tumor angiogenesis by taking part in intercellular crosstalk between tumor cells and nearby stromal cells (Wu et al, 2019a;Wu et al, 2019b;Liu et al, 2022).…”

Section: Exosomes' Immunomodulation Properties and Immunotherapeutic ...mentioning

confidence: 99%

Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview

Hadizadeh

Bagheri

Shamsara

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The main goals of medicine consist of early detection and effective treatment of different diseases. In this regard, the rise of exosomes as carriers of natural biomarkers has recently attracted a lot of attention and managed to shed more light on the future of early disease diagnosis methods. Here, exosome biogenesis, its role as a biomarker in metabolic disorders, and recent advances in state-of-art technologies for exosome detection and isolation will be reviewed along with future research directions and challenges regarding the manipulation and genetic engineering of exosomes for potential in vitro and in vivo disease diagnosis approaches.

show abstract

“…The malignancies are further characterized by the tissues that they originate from, which include epithelial carcinoma, germ cell carcinoma, and stromal cell carcinoma. Among all the subcategories, epithelial ovarian cancer (EOC) is the most commonly diagnosed type, accounting for approximately 90% of ovarian cancer cases [ 11 , 12 ], with high-grade serous ovarian carcinoma (HGSOC) being the most predominant histotype of EOC. The treatment options for ovarian cancer depend on the histological subtypes and stages of the disease.…”

Section: Difficulties In Current Ovarian Cancer Treatmentmentioning

confidence: 99%

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

Zhan

Yung

Siu

et al. 2022

IJMS

View full text Add to dashboard Cite

Ovarian cancer is one of the most lethal gynecological cancers worldwide. The poor prognosis of this malignancy is substantially attributed to the inadequate symptomatic biomarkers for early diagnosis and effective remedies to cure the disease against chemoresistance and metastasis. Ovarian cancer metastasis is often relatively passive, and the single clusters of ovarian cancer cells detached from the primary ovarian tumor are transcoelomic spread by the peritoneal fluid throughout the peritoneum cavity and omentum. Our earlier studies revealed that lipid-enriched ascitic/omental microenvironment enforced metastatic ovarian cancer cells to undertake metabolic reprogramming and utilize free fatty acids as the main energy source for tumor progression and aggression. Intriguingly, cell susceptibility to ferroptosis has been tightly correlated with the dysregulated fatty acid metabolism (FAM), and enhanced iron uptake as the prominent features of ferroptosis are attributed to the strengthened lipid peroxidation and aberrant iron accumulation, suggesting that ferroptosis induction is a targetable vulnerability to prevent cancer metastasis. Therefore, the standpoints about tackling altered FAM in combination with ferroptosis initiation as a dual-targeted therapy against advanced ovarian cancer were highlighted herein. Furthermore, a discussion on the prospect and challenge of inducing ferroptosis as an innovative therapeutic approach for reversing remedial resistance in cancer interventions was included. It is hoped this proof-of-concept review will indicate appropriate directions for speeding up the translational application of ferroptosis-inducing compounds (FINs) to improve the efficacy of ovarian cancer treatment.

show abstract

New Approaches and Biomarker Candidates for the Early Detection of Ovarian Cancer

Cited by 7 publications

References 62 publications

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

Contact Info

Product

Resources

About