New approaches and omics tools for mining of vaccine candidates against vector-borne diseases

Kuleš, Josipa; Horvatić, Anita; Guillemin, Nicolas; Galán, Asier; Mrljak, Vladimir; Bhide, Mangesh

doi:10.1039/c6mb00268d

Cited by 26 publications

(16 citation statements)

References 123 publications

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“…More recently, new technologies have made tractable approaches based on a deeper understanding of complex tick-pathogen-host interactions (de la Fuente et al, 2016a; Kuleš et al, 2016). For example, SILK (a salivary gland-expressed flagelliform protein of unknown function) and TROSPA (tick receptor for OspA localized in the gut) facilitate transmission of cattle tick-borne pathogens, Anaplasma marginale and Babesia bigemina , respectively.…”

Section: Vaccinesmentioning

confidence: 99%

Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface

Kazimírová

Thangamani

Bartíková

et al. 2017

Front. Cell. Infect. Microbiol.

106

103

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Ticks are efficient vectors of arboviruses, although less than 10% of tick species are known to be virus vectors. Most tick-borne viruses (TBV) are RNA viruses some of which cause serious diseases in humans and animals world-wide. Several TBV impacting human or domesticated animal health have been found to emerge or re-emerge recently. In order to survive in nature, TBV must infect and replicate in both vertebrate and tick cells, representing very different physiological environments. Information on molecular mechanisms that allow TBV to switch between infecting and replicating in tick and vertebrate cells is scarce. In general, ticks succeed in completing their blood meal thanks to a plethora of biologically active molecules in their saliva that counteract and modulate different arms of the host defense responses (haemostasis, inflammation, innate and acquired immunity, and wound healing). The transmission of TBV occurs primarily during tick feeding and is a complex process, known to be promoted by tick saliva constituents. However, the underlying molecular mechanisms of TBV transmission are poorly understood. Immunomodulatory properties of tick saliva helping overcome the first line of defense to injury and early interactions at the tick-host skin interface appear to be essential in successful TBV transmission and infection of susceptible vertebrate hosts. The local host skin site of tick attachment, modulated by tick saliva, is an important focus of virus replication. Immunomodulation of the tick attachment site also promotes co-feeding transmission of viruses from infected to non-infected ticks in the absence of host viraemia (non-viraemic transmission). Future research should be aimed at identification of the key tick salivary molecules promoting virus transmission, and a molecular description of tick-host-virus interactions and of tick-mediated skin immunomodulation. Such insights will enable the rationale design of anti-tick vaccines that protect against disease caused by tick-borne viruses.

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Section: Vaccinesmentioning

confidence: 99%

Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface

Kazimírová

Thangamani

Bartíková

et al. 2017

Front. Cell. Infect. Microbiol.

106

103

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“…Acaricides are proven useful for canine babesiosis prevention, with reports showing protection between 88-100% lasting 1-3 months, although their effi cacy was mostly tested for B. canis transmission by D. reticulates [34]. Nevertheless, there is an emerging problem of acaricide resistance, so development of new tick control strategies such as anti-tick vaccines is underway, exploiting new research methodologies such as ˝omics˝ tools [196].…”

Section: Prevention (Prophylaxis)mentioning

confidence: 99%

Canine Babesiosis: Where Do We Stand?

et al. 2018

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Canine babesiosis is a tick-borne disease caused by protozoal haemoparasites of different Babesia species. Babesiosis is one of the most important globally extended and quickly spreading tick-borne infections of dogs. This comprehensive review gives an in-depth overview of Babesia species currently identifi ed in dogs together with relevant vector tick species and their geographical distribution, life cycle and transmission of parasite. The main mechanisms in the pathogenesis of babesiosis are described and elucidated by recent literature overview. As Babesia infection causes a disease with very variable clinical manifestations, special attention is given to clinical signs, laboratory features and clinicopathological fi ndings. The diagnosis of canine babesiosis by microscopy, serological and molecular methods is reviewed, together with recent advances in mass spectrometry based assays. Accurate detection and species recognition are important for the selection of the appropriate therapy, monitoring and prediction of the outcome of the disease. Finally, guidelines for the treatment and prevention of canine babesiosis are given.

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“…Advances in tick genomics have also facilitated the characterization of the impact of co-infections and microbiome composition on tick vector capacity (Narasimhan and Fikrig, 2015 ; Vayssier-Taussat et al, 2015 ). These results greatly improve our understanding of tick biology and will advance research on tick-host-pathogen interactions to develop effective and environmentally friendly measures to control ticks and the many pathogens and parasites they transmit (de la Fuente and Contreras, 2015 ; Benelli et al, 2016 ; Carr and Roe, 2016 ; de la Fuente et al, 2016b ; Esteve-Gassent et al, 2016 ; Kuleš et al, 2016 ).…”

Section: Discussionmentioning

confidence: 96%