New Approaches and Recommendations for Risk‐Adapted Breast Cancer Screening

Abstract

Population‐based breast cancer screening using mammography as the gold standard imaging modality has been in clinical practice for over 40 years. However, the limitations of mammography in terms of sensitivity and high false‐positive rates, particularly in high‐risk women, challenge the indiscriminate nature of population‐based screening. Additionally, in light of expanding research on new breast cancer risk factors, there is a growing consensus that breast cancer screening should move toward a risk‐adapted approach. Recent advancements in breast imaging technology, including contrast material‐enhanced mammography (CEM), ultrasound (US) (automated‐breast US, Doppler, elastography US), and especially magnetic resonance imaging (MRI) (abbreviated, ultrafast, and contrast‐agent free), may provide new opportunities for risk‐adapted personalized screening strategies. Moreover, the integration of artificial intelligence and radiomics techniques has the potential to enhance the performance of risk‐adapted screening. This review article summarizes the current evidence and challenges in breast cancer screening and highlights potential future perspectives for various imaging techniques in a risk‐adapted breast cancer screening approach.Evidence Level1.Technical EfficacyStage 5.

Exploring the Protective Effect against 7,12-Dimethylbenz[a]anthracene-Induced Breast Tumors of Palmitoylethanolamide

“…In transitioning countries, including Melanesia, Western Africa, Micronesia/Polynesia, and the Caribbean, breast cancer-related deaths are significantly higher, with an incidence rate approximately 88% than in transitioning countries such as Australia/New Zealand, Western Europe, Northern America, and Northern Europe. To detect and predict breast cancer at an early stage, imaging techniques such as photoacoustic (PA) imaging, ultrasonography, magnetic resonance imaging (MRI), and mammography are commonly used . Among these techniques, PA imaging has shown significant potential in clinical applications, particularly in oncology, as it enables early cancer detection, tumor characterization, and monitoring of treatment response. , Previous studies posited that the uncontrolled progression of breast cancer cells can be attributed to perturbations in multiple factors, including aberrant generation of reactive oxygen species (ROS), DNA damage, and exposure to ultraviolet (UV) radiation.…”

“…To detect and predict breast cancer at an early stage, imaging techniques such as photoacoustic (PA) imaging, ultrasonography, magnetic resonance imaging (MRI), and mammography are commonly used . Among these techniques, PA imaging has shown significant potential in clinical applications, particularly in oncology, as it enables early cancer detection, tumor characterization, and monitoring of treatment response. , Previous studies posited that the uncontrolled progression of breast cancer cells can be attributed to perturbations in multiple factors, including aberrant generation of reactive oxygen species (ROS), DNA damage, and exposure to ultraviolet (UV) radiation. These factors act by altering multiple pathways-related molecules, including the mitochondrial pathway, PI3K/AKT pathway, FasL/Fas pathway, nuclear factor-κB (NF-κB) pathway, and ROS-mediated pathway .…”