New Approaches to Cardioplegia: Alternatives to Hyperkalemia

Chambers, David J.; Fallouh, Hazem B.

doi:10.1007/978-3-211-85548-5_12

Cited by 1 publication

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“…Increasing the extracellular concentration of K þ in a cardioplegic solution causes a depolarization of the resting membrane potential of the cardiomyocytes (normally around 85 mV) to a value that is less negative. When the membrane potential reaches approximately -65 mV, the voltage-dependent fast Na þ channels are inactivated, thereby inducing diastolic arrest [10,11]. To obtain a resting membrane potential of less negative than -65 mV, extracellular K þ concentrations of up to 30 mM are used [11] with the risk of causing coronary artery constriction at normothermia (Table 1, Figure 3).…”

Section: Discussionmentioning

confidence: 99%

How to avoid severe coronary vasoconstriction in potassium induced cardioplegia

Qin

Chen

Sjöberg

et al. 2018

Scandinavian Cardiovascular Journal

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Objectives. The aim of this study was to investigate how high K þ concentrations can be safely used in cardioplegic solutions without causing severe coronary artery vasocontraction. Design. Twenty-four 50 kg pigs were used. The distal part of the left anterior descending coronary artery was cut into ring segments and transferred into organ baths with Krebs solution bubbled with 95% O 2 and 5% CO 2. K þ concentrations between 16 and 127 mM were used to induce vasocontractions at 37, 22, 15, and 8 C. Mg 2þ (0-20 mM) were used to attenuate K þ induced vasocontractions. Results. K þ-Krebs solution 127 mM at 37 C induced a strong, sustained vasocontraction defined as 100%.

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Section: Discussionmentioning

confidence: 99%