New Approaches to Manage Infections in Transplant Recipients: Report From the 2023 GTI (Infection and Transplantation Group) Annual Meeting

Serris, Alexandra; Coussement, Julien; Pilmis, Benoît; De Lastours, Victoire; Dinh, Aurélien; Parquin, François; Epailly, Eric; Ader, Florence; Lortholary, Olivier; Morelon, Emmanuel; Kamar, Nassim; Forcade, Edouard; Lebeaux, David; Dumortier, Jérôme; Conti, Filomena; Lefort, Agnes; Scemla, Anne; Kaminski, Hannah

doi:10.3389/ti.2023.11859

Cited by 2 publications

(1 citation statement)

References 68 publications

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“…The integration of these guidelines ensures a comprehensive and tailored approach to UTI management in kidney transplant recipients. Research into novel antimicrobial agents and immunomodulatory therapies, as well as the significance of innovative nonantibiotic-based approaches, may offer more targeted and effective options, mitigating the risk of infections while minimizing adverse effects [44–48].…”

Section: Management Of Urinary Tract Infections In Elderly Kidney Tra...mentioning

confidence: 99%

Effect of increasing age and ureteral stent implantation on urinary tract infections after kidney transplantation – update of recent literature

Omic,

Eder

2024

Current Opinion in Urology

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Purpose of review This review aims to present the recent literature regarding effects of aging and ureteral stent implantation (UrS) on the risk of urinary tract infections (UTIs) in kidney transplant (KTX) recipients. Recent findings UTIs in kidney transplant recipients remain a clinical challenge and represent a leading cause of morbidity, hospitalization rates, and mortality. Higher age was described as a significant risk factor for UTIs in several studies including a recent Brazilian analysis, indicating a 3.6%/years of age increase in UTI risk. Subsequently, a large meta-analysis, published in 2023, confirmed the correlation between older age and elevated UTI risk. The Swiss Transplant Cohort Study in 2022, largest of its kind, similarly confirmed a link between advanced age and heightened risk of recurrent UTIs in KTX. A recent prospective study highlighted UrS placement as a modifiable risk factor, emphasizing the need for careful consideration and antibiotic prophylaxis. Additionally, the type of stents played a crucial role, with external stents associated with a 1.69 times higher UTI risk. The challenge of determining optimal UrS removal timing further complicates posttransplant care, with insufficient evidence to guide practices. Summary The aging population of KTX recipients requires a personalized approach to effectively reduce and manage UTIs as one of the most important complications following KTX. Prophylactic stent implantation is successful in lowering ureteral complications, however, is associated with an increased incidence of UTIs. To reduce the increased risk of UTIs, the length of stent insertion requires strict supervision and maintenance.

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Section: Management Of Urinary Tract Infections In Elderly Kidney Tra...mentioning

confidence: 99%

Effect of increasing age and ureteral stent implantation on urinary tract infections after kidney transplantation – update of recent literature

Omic,

Eder

2024

Current Opinion in Urology

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Synthesis of New 3-(Benzo[d]Oxazol-2-Yl)-3-(4-Fluorophenyl)Propanoic Acid Intermediate and its Derivatives as Antimicrobial Agent, Molecular Docking Studies

Dupati,

Sapuri-Butti,

Thumma

et al. 2024

Chemistry Africa

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New Approaches to Manage Infections in Transplant Recipients: Report From the 2023 GTI (Infection and Transplantation Group) Annual Meeting

Cited by 2 publications

References 68 publications

Effect of increasing age and ureteral stent implantation on urinary tract infections after kidney transplantation – update of recent literature

Effect of increasing age and ureteral stent implantation on urinary tract infections after kidney transplantation – update of recent literature

Synthesis of New 3-(Benzo[d]Oxazol-2-Yl)-3-(4-Fluorophenyl)Propanoic Acid Intermediate and its Derivatives as Antimicrobial Agent, Molecular Docking Studies

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