New approaches to the pathogenesis of peptic ulcer based on the protective action of saliva with special reference to roughage, vegetable fibre and fermented milk products

Malhotra, S. L.

doi:10.1016/0306-9877(78)90021-x

Cited by 8 publications

(7 citation statements)

References 39 publications

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“…There have been few reports about the fermented milk such as yogurt, except for that the relative dietary preponderance of short-chain fatty acids has a protective action (14). In the present study, LG21 yogurt showed a dose-dependent gastroroprotective effect against 0.6 M HCl-induced acute gastric lesions, and this gastroprotective action was attenuated by the pre-treatment with indomethacin, suggesting the involvement of prostaglandin in the gastroprotective mechanism by LG21 yogurt.…”

supporting

confidence: 49%

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Yogurt Containing Lactobacillus gasseri OLL2716 Exerts Gastroprotective Action Agaisnt Acute Gastric Lesion and Antral Ulcer in Rats

Uchida¹,

Kurakazu²

2004

J Pharmacol Sci

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Abstract. Yogurt containing Lactobacillus gasseri OLL2716 (LG21 yogurt) is reported to improve Helicobacter pylori-induced gastric mucosal inflammation in clinical studies. However, other beneficial effects of LG21 yogurt have not been clarified. Therefore, we examined whether LG21 yogurt exhibits a gastroprotective action against acute gastric lesion or antral ulcer in rats. Moreover, the mechanism of gastroprotective action was also evaluated. After fasting, acute gastric lesions were induced by 0.6 M HCl. Gastric mucosal folds were stained by oral administration of methyl violet. Antral ulcers were induced by the combined administration of diethyldithiocarbamate and HCl in refed rats after fasting. LG21 yogurt was orally administered before HCl treatment or staining the mucosal folds.LG21 yogurt significantly and dosedependently inhibited the formation of acute gastric lesions, and this gastroprotective action was attenuated by pretreatment with indomethacin. LG21 yogurt also significantly increased prostaglandin E 2 generation in the gastric mucosa. Stained length of gastric mucosal fold was reduced by LG21 yogurt. Antral ulcer formation was also significantly inhibited by LG21 yogurt. From the above results, it was found that the ingestion of LG21 yogurt is useful for the prevention of gastric ulcer. Moreover, endogenous prostaglandin was suggested to be one of the gastroprotective mechanisms of LG21 yogurt.

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supporting

confidence: 49%

“…On the active substance for gastroprotective action, Malhotra (2) reported the importance of short-chain fatty acids present in milk, yogurt, and other fermented milk products by retarding gall bladder contraction.…”

Section: Introductionmentioning

confidence: 99%

Yogurt Containing Lactobacillus gasseri OLL2716 Exerts Gastroprotective Action Agaisnt Acute Gastric Lesion and Antral Ulcer in Rats

Uchida¹,

Kurakazu²

2004

J Pharmacol Sci

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“…Therefore, the role of milk needs to be further investigated. Differences in the prevalence of peptic ulcer disease among communities has been attributed to variation in diet and eating patterns, and fermented milk products have been suggested to protect against peptic ulcer (Malhotra, 1978). Bile has been suggested to play a causative role in the development of ulcer.…”

Section: Discussionmentioning

confidence: 99%

“…Bile has been suggested to play a causative role in the development of ulcer. Production of salivary mucus, stimulated by fermented milk products such as yoghurt, will thereby prevent peptic ulceration through a decreased¯ow rate of bile and reduced alkalinity (Malhotra, 1978). Shortchain fatty acids also retard gall bladder contraction.…”

Section: Discussionmentioning

confidence: 99%

Fermented milk products are associated to ulcer disease. Results from a cross-sectional population study

Elmståhl¹,

Svensson²,

Berglund³

1998

Eur J Clin Nutr

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Background: Prevalence of peptic ulcer disease has been associated to diet. Some dietary factors seem to have bactericidal effect which may modify the risk of peptic ulcer disease. The objective was to analyze associations between dietary habits and peptic ulcers. Design: A cross sectional population study. Subjects: One thousand, one hundred and thirty-®ve subjects out of 11 700 randomly invited men and women, aged 46±67 y, participating in a diet and disease study during 1991±1993. The study population comprised of 764 cases with reported peptic ulcer, 142 with dyspeptic symptoms and 229 randomly selected controls. Methods: X-ray examinations and endoscopies were reviewed and 332 out of 764 peptic ulcer cases were veri®ed. Mean daily intake of foods and nutrients were assessed with a combined 7 d menu book and a quantitative food frequency questionnaire, including dietary supplements. Results: Subjects with veri®ed ulcer had lower intake of fermented milk products and vegetables and higher intake of milk, meat and bread than controls. Intake of total fat, saturated and monounsaturated fatty acids and linolenic acid were higher in the ulcer group. Higher intake of fermented milk products, by quintiles showed a decreased ulcer risk; odds ratio 0.82 (0.71±0.95), adjusted for covariates below. Higher intake of milk, by quintiles, was associated with an increased risk of ulcer; odds ratio 1.17 (1.03±1.32). Smoking, foreign ethnicity and being unmarried or divorced were covariates associated to ulcer. Conclusion: This study indicates the multifactorial etiology of peptic ulcer including dietary factors. High intake of fermented milk products was associated with decreased risk for ulcer, whereas increased risk was noted for high milk intake. Sponsorship: The study was supported by the Swedish Cancer Society.

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“…Salivary mucus swallowed with food reduces the alkalinity of bile and therefore prevents damage of mucous cells. 128 Saliva is also helpful in the diagnosis and prevention of occupational diseases. For example, exposure to the environmental contaminant phthalate results in several diseases.…”

Section: Othermentioning

confidence: 99%

Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases

Prasad

Tyagi

Aggarwal

2016

Exp Biol Med (Maywood)

106

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Inflammation is a part of the complex biological response of inflammatory cells to harmful stimuli, such as pathogens, irritants, or damaged cells. This inflammation has been linked to several chronic diseases including cancer, atherosclerosis, rheumatoid arthritis, and multiple sclerosis. Major biomarkers of inflammation include tumor necrosis factor, interleukins (IL)-1, IL-6, IL-8, chemokines, cyclooxygenase, 5-lipooxygenase, and C-reactive protein, all of which are regulated by the transcription factor nuclear factor-kappaB. Although examining inflammatory biomarkers in blood is a standard practice, its identification in saliva and/or urine is more convenient and non-invasive. In this review, we aim to (1) discuss the detection of these inflammatory biomarkers in urine and saliva; (2) advantages of using salivary and urinary inflammatory biomarkers over blood, while also weighing on the challenges and/or limitations of their use; (3) examine their role(s) in connection with diagnosis, prevention, treatment, and drug development for several chronic diseases with inflammatory consequences, including cancer; and (4) explore the use of innovative salivary and urine based biosensor strategies that may permit the testing of biomarkers quickly, reliably, and cost-effectively, in a decentralized setting.

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New approaches to the pathogenesis of peptic ulcer based on the protective action of saliva with special reference to roughage, vegetable fibre and fermented milk products

Cited by 8 publications

References 39 publications

Yogurt Containing Lactobacillus gasseri OLL2716 Exerts Gastroprotective Action Agaisnt Acute Gastric Lesion and Antral Ulcer in Rats

Yogurt Containing Lactobacillus gasseri OLL2716 Exerts Gastroprotective Action Agaisnt Acute Gastric Lesion and Antral Ulcer in Rats

Fermented milk products are associated to ulcer disease. Results from a cross-sectional population study

Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases

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