New aspects in the treatment of priapism

Portillo, F. J. Martínez; Jünemann, Klaus-Peter

doi:10.1111/j.1439-0272.1999.tb01451.x

Cited by 10 publications

(1 citation statement)

References 31 publications

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“…This method is estimated to achieve an average success rate of up to 80%. The third step in treatment involves surgical shunting procedures [21]. While medical intervention or shunt surgery can ultimately lead to successful detumescence, it is noteworthy that a significant proportion of these individuals experience ED afterward.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Rat Model Study: Is There Any Effect of Syringic Acid on Ischemia-Reperfusion Injury in Priapism?

Sarikaya,

Kölükçü,

Unsal

et al. 2023

Cureus

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The purpose of this research is to examine the impact of syringic acid on ischemia-reperfusion injury in cavernosal tissue, utilizing a rat model of induced priapism. Materials and methodsA total of 24 rats were allocated into three groups. Group 1 was designated as the control group, while Group 2 underwent ischemia-reperfusion injury assessment using the priapism model. Group 3 underwent the same procedures as Group 2, with the addition of intraperitoneal administration of syringic acid (100 mg/kg) 60 min after priapism initiation. All rats underwent penectomy, and sufficient blood samples were collected. Histopathological assessment of penile cavernosal tissue involved grading tissue damage, inflammation, vasocongestion, desquamation, and edema on a scale of 0-3 (0: normal, 1: mild, 2: moderate, 3: severe). ResultSignificant differences were observed among the three groups in terms of IL-1 beta and TNF-alpha levels (p=0.001 and p<0.001, respectively). IL-1 beta and TNF-alpha levels in Group 2 were found to be significantly higher than Group 3 (p=0.003 and p=0.004). There was also a significant difference among the three groups in terms of median MDA levels (p<0.001). Furthermore, the median MDA level in Group 2 was found to be significantly higher than that in Group 3 (p<0.001). While significant differences were observed among the three groups in terms of median SOD and GSH-px levels, no significant difference was found among the groups in terms of median PC levels (p=0.004, p= 0.048, and p=0.159, respectively). In direct microscopic examination, a significant improvement in pathological scores was noted in Group 3 compared to Group 2 (p<0.001). ConclusionSyringic acid demonstrated protective properties against ischemia-reperfusion injury caused by priapism in cavernosal tissue.

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Section: Discussionmentioning

confidence: 99%

An Experimental Rat Model Study: Is There Any Effect of Syringic Acid on Ischemia-Reperfusion Injury in Priapism?

Sarikaya,

Kölükçü,

Unsal

et al. 2023

Cureus

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High-flow priapism in acute lymphatic leukaemia

Mentzel

Kentouche²,

Doerfel³

et al. 2004

Pediatr Radiol

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Priapism is defined as prolonged and persistent erection of the penis without sexual stimulation. It is associated with excessive hyperleukocytosis (e.g. in acute or chronic leukaemia); however, this complication is rarely seen in the pediatric population. We report a 12-year-old boy suffering from acute leukaemia presenting with, at first intermittent, but increasingly persistent erection. Doppler US revealed signs of high-flow priapism. MRI excluded intrapelvic tumour masses, and three-dimensional contrast-enhanced MR angiography could not demonstrate an arteriovenous fistula or thrombosis. Cavernosal blood-gas measurement was in agreement with high-flow priapism. On the basis of the imaging findings, invasive therapeutic management was avoided in our patient with a successful outcome.

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