We consider F-theory compactifications on genus-one fibered Calabi-Yau manifolds with their fibers realized as hypersurfaces in the toric varieties associated to the 16 reflexive 2D polyhedra. We present a base-independent analysis of the codimension one, two and three singularities of these fibrations. We use these geometric results to determine the gauge groups, matter representations, 6D matter multiplicities and 4D Yukawa couplings of the corresponding effective theories. All these theories have a non-trivial gauge group and matter content. We explore the network of Higgsings relating these theories. Such Higgsings geometrically correspond to extremal transitions induced by blow-ups in the 2D toric varieties. We recover the 6D effective theories of all 16 toric hypersurface fibrations by repeatedly Higgsing the theories that exhibit Mordell-Weil torsion. We find that the three Calabi-Yau manifolds without section, whose fibers are given by the toric hypersurfaces in P 2 , P 1 × P 1 and the recently studied P 2 (1, 1, 2), yield F-theory realizations of SUGRA theories with discrete gauge groups Z 3 , Z 2 and Z 4 . This opens up a whole new arena for model building with discrete global symmetries in F-theory. In these three manifolds, we also find codimension two I 2 -fibers supporting matter charged only under these discrete gauge groups. Their 6D matter multiplicities are computed employing ideal techniques and the associated Jacobian fibrations. We also show that the Jacobian of the biquadric fibration has one rational section, yielding one U(1)-gauge field in F-theory. Furthermore, the elliptically fibered Calabi-Yau manifold based on dP 1 has a U(1)-gauge field JHEP01 (2015)142 induced by a non-toric rational section. In this model, we find the first F-theory realization of matter with U(1)-charge q = 3.