New aspects of organophosphorus pesticides. VI. Organophosphorus insect chemosterilants.

Bořkovec, Alexej B.

doi:10.1007/978-1-4612-9849-6_6

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…All these untoward effects are nevertheless possible based on mechanistic criteria (e.g., aryl formamidase inhibition depletes cellular nicotinamide adenine dinucleotide levels in avian species and DNA methylation with O-methyl phosphates and alkylation with OPs containing N-chloroethyl substituents used as antineoplastic agents). Aziridinylphosphonitriles, although highly effective as insect chemosterilants (149), were never allowed for use because of known or suspected carcinogenic effects.…”

Section: Relation To Human Health and Diseasementioning

confidence: 99%

Organophosphorus Xenobiotic Toxicology

Casida

2017

Annu. Rev. Pharmacol. Toxicol.

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Originally, organophosphorus (OP) toxicology consisted of acetylcholinesterase inhibition by insecticides and chemical threat agents acting as phosphorylating agents for serine in the catalytic triad, but this is no longer the case. Other serine hydrolases can be secondary OP targets, depending on the OP structure, and include neuropathy target esterase, lipases, and endocannabinoid hydrolases. The major OP herbicides are glyphosate and glufosinate, which act in plants but not animals to block aromatic amino acid and glutamine biosynthesis, respectively, with safety for crops conferred by their expression of herbicide-tolerant targets and detoxifying enzymes from bacteria. OP fungicides, pharmaceuticals including calcium retention agents, industrial chemicals, and cytochrome P450 inhibitors act by multiple noncholinergic mechanisms, often with high potency and specificity. One type of OP-containing fire retardant forms a highly toxic bicyclophosphate γ-aminobutyric acid receptor antagonist upon combustion. Some OPs are teratogenic, mutagenic, or carcinogenic by known mechanisms that can be avoided as researchers expand knowledge of OP chemistry and toxicology for future developments in bioregulation.

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Section: Relation To Human Health and Diseasementioning

confidence: 99%

Organophosphorus Xenobiotic Toxicology

Casida

2017

Annu. Rev. Pharmacol. Toxicol.

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“…Two other classes of chemosterilants shown in Table 1 are of importance. The nonalkylating phosphorus amides (16), particularly their bestknown representative hempa (hexamethylphosphoric triamide), are a potentially useful group of chemosterilants. Toxicological data on hempa (28) show only moderate mammalian toxicity, but the compound, or perhaps its metabolite (29), is mutagenic, and the considerations regarding its use in any of the sterility pest control techniques will not be qualitatively different from those described earlier for alkylating agents.…”

Section: Safety Aspects Of Chemosterilantsmentioning

confidence: 99%

Control and management of insect populations by chemosterilants.

Bořkovec¹

1976

Environ Health Perspect

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Chemosterilants, i.e., chemical compounds that interfere with the reproduction potential of sexually reproducing organisms, can be used in three new approaches to insect control. In the sterile-insect release technique, the principal problem is to develop compounds and methods for their application that would not result in introducing harmful residues into the environment. Because of the unusual and often unique circumstances connected with releasing large numbers of sterilized insects, the residue problem and its cost-benefit aspects must be examined individually for each intended control or eradication program. In the direct application technique, chemosterilants must meet the same efficiency and safety standards required from approved insecticides. Combined insecticidal and sterilizing activity is characteristic for some compounds now being investigated. In the genetic technique, chemosterilants may be used for inducing heritable changes in the insect's genome under laboratory conditions, and such procedures would not present any residue problems. Only the first two chemosterilant techniques are approaching practical application, and their safety aspects require detailed evaluation and assessment.

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New aspects of organophosphorus pesticides. VI. Organophosphorus insect chemosterilants.

Cited by 2 publications

References 22 publications

Organophosphorus Xenobiotic Toxicology

Organophosphorus Xenobiotic Toxicology

Control and management of insect populations by chemosterilants.

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