New aspects of the neurophysiological mechanism of action of nootropic drugs

Воронина, Т. А.; Krapivin, S. V.

doi:10.1007/bf00840807

Cited by 1 publication

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“…A typical example of the use ofthis technique is the frequency analysis based on the Fast Fourier Transform algorithm, by which we can establish profiles of cognition enhancer effects on the power spectrum of EEG. Drugs may modify the relative or absolute power of some frequency bands of the EEG in normal animals or humans ( Costa et al, 1988;Dimovet al, 1984;Guazelli et al, 1987), or interact with the effects of anoxia or aging on the EEG ( Ostrovskaya et al, 1983;Poschelet al, 1985;Saletu and Grunberger, 1985;Saletu et al, 1984;Voronina and Krapivin, 1986). These effects may be of special interest when the rhythms modified by the drug are related to cognition, as is the case with the hippocampal theta in rodents.…”

Section: Elektrophysiologische Modelle Zur Untersuchung Von Wahmehmunmentioning

confidence: 99%

Electrophysiological Models for the Study of Cognition Enhancers

Delacour

Bassant²,

Onofrj³

et al. 1990

Pharmacopsychiatry

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Electrophysiological approaches range from global EEG studies to single unit recordings. Quantified EEG studies indicate that cognition enhancers increase the power of fast-frequency (beta) EEG activity in humans and the duration of hippocampal theta in animals. A problem here is the distinction between improved cognition and increases in general arousal, although the two might have the same end effect. A second global approach is the use of the evoked potential or even the conditioned evoked potential, for example the P 300 wave. This approach, using defined brain circuits, would appear to be more specific than global EEG models. Both approaches can be used in parallel studies in animals and man. Studies at more cellular levels can only be used in animals and suffer from severe constraints. The most precise approach, single cell recording, cannot be conducted in freely behaving animals, whereas multi-unit approaches in awake animals tend to produce many artefacts. However, techniques using microintophoretically applied drugs in freely moving rodents and monkeys can contribute to the understanding of mechanisms of action. In vitro studies, for example long-term potentiation in hippocampal slices, may represent a neuronal model of learning but its role in normal brain function has still not been elucidated.

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Section: Elektrophysiologische Modelle Zur Untersuchung Von Wahmehmunmentioning

confidence: 99%