New aspects of the relationship among hypertension, obesity, and the kidneys

Sachse, Anja; Wolf, Günter

doi:10.1007/s11906-008-0026-x

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…The relative contributions of EMT-derived cells, MSCs, and fibrocytes to CRF remain to be determined. The reported correlation between obesity and CRF (Thakur et al, 2006; Sachse and Wolf, 2008) could be explained by possible migration of MSCs from WAT.…”

Section: Introductionmentioning

confidence: 98%

Alternative origins of stroma in normal organs and disease

et al. 2012

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Stromal fibroblasts are a new prospective drug target. Mesenchymal stromal cells (MSCs) and monocyte-derived stromal cells, also known as fibrocytes, are distinct fibroblastic populations derived from separate lineages. Mesenchymal and myeloid fibroblast progenitors are multipotent, serve as progenitor cells in animal models, and are implicated in several diseases. In addition, epithelial-mesenchymal transition (EMT) has been established as a mechanism for generation of stromal cells. Organ sources, relative contributions, and functions of these populations in normal development and pathology are not well understood. Innovative approaches are needed to identify markers that can distinguish these stromal populations.

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Section: Introductionmentioning

confidence: 98%

Alternative origins of stroma in normal organs and disease

et al. 2012

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“…Hypertension-induced kidney damage is associated with increased cardiovascular morbidity and mortality [ 10 - 13 ]. The coexistence of hypertension and obesity [ 14 , 15 ], hyperlipidemia [ 16 ] or diabetes [ 17 ] results in worse renal dysfunction than isolated occurrence of either risk factor alone. Evidence from numerous clinical trials has demonstrated benefits of blood pressure (BP) control [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Blood Pressure on Kidney Function in the Elderly: A Cross-Sectional Study

Zhang

Xiaocong²,

Huang³

et al. 2013

Kidney Blood Press Res

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Background/Aims: Intensive blood pressure (BP) target decreases blood perfusion of kidneys that attenuates the benefits of BP treatment in elderly hypertensive individuals. The optimal BP goal for renal function in the hypertensive elderly has been unclear. We investigated the impact of BP on renal function to define the appropriate BP target in the elderly. Methods: A total of 28,258 elderly subjects were categorized into normotensive (Norm), hypotensive (Hypo) and hypertensive (Hyper) groups according to BP levels. Systolic, diastolic and pulse BP (SBP, DBP and PBP) were further stratified by 10 mmHg. Blood urea nitrogen, serum creatinine, uric acid, glomerular filtration rate (GFR), renal insufficiency prevalence (RIP) and proteinuria prevalence (PP) were compared among different groups and BP strata. The RIP and PP in the elderly with obesity, hyperlipidemia or diabetes in Norm, Hypo and Hyper groups were evaluated. Results: GFR in Hypo and Hyper groups was significantly lower than that in Norm group. The RIP and PP was higher in Hypo and Hyper groups than that in the Norm group. Proteinuria became more prevalent when SBP was >140 mmHg or <90 mmHg. DBP>80mmHg increased PP while DBP<70 mmHg increased RIP. PBP>60 mmHg led to an increased RIP and PP. Obesity or hyperlipidemia only combined with hypertension caused a significantly increased RIP and PP. Diabetes independent of hypertension contributed to higher RIP and PP. Conclusions: The most beneficial BP target for kidney function in the elderly may be SBP of 90-140 mmHg and DBP of 70-80 mmHg. PBP <60 mmHg may be appropriate.

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“…Obesity, hallmarked by the overgrowth of WAT, is associated with progression of a number of fibrotic conditions [167]. This includes chronic renal fibrosis [169] and liver cirrhosis [170]. Building evidence also points to the importance of AT remodeling for subcutaneous fibrosis development in patients with scleroderma [168].…”

Section: Adipose Cell Engagement In Fibrosismentioning

confidence: 99%

Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences

Eckel‐Mahan

Latre

Kolonin

2020

Cells

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Adipose tissue (AT) is comprised of a diverse number of cell types, including adipocytes, stromal cells, endothelial cells, and infiltrating leukocytes. Adipose stromal cells (ASCs) are a mixed population containing adipose progenitor cells (APCs) as well as fibro-inflammatory precursors and cells supporting the vasculature. There is growing evidence that the ability of ASCs to renew and undergo adipogenesis into new, healthy adipocytes is a hallmark of healthy fat, preventing disease-inducing adipocyte hypertrophy and the spillover of lipids into other organs, such as the liver and muscles. However, there is building evidence indicating that the ability for ASCs to self-renew is not infinite. With rates of ASC proliferation and adipogenesis tightly controlled by diet and the circadian clock, the capacity to maintain healthy AT via the generation of new, healthy adipocytes appears to be tightly regulated. Here, we review the contributions of ASCs to the maintenance of distinct adipocyte pools as well as pathogenic fibroblasts in cancer and fibrosis. We also discuss aging and diet-induced obesity as factors that might lead to ASC senescence, and the consequences for metabolic health.

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New aspects of the relationship among hypertension, obesity, and the kidneys

Cited by 4 publications

References 29 publications

Alternative origins of stroma in normal organs and disease

Alternative origins of stroma in normal organs and disease

The Impact of Blood Pressure on Kidney Function in the Elderly: A Cross-Sectional Study

Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences

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