New aspects on the distribution and metabolism of essential trace elements after dietary exposure to toxic metals

Abdulla, M.; Chmielnicka, Jadwiga

doi:10.1007/bf02917176

Cited by 121 publications

(74 citation statements)

References 119 publications

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“…Vegetable constitutes are also a crucial part of the human diet since they contain carbohydrates, proteins in addition to vitamins, inorganics and trace elements (10). However, the intake of heavy metal-contaminated vegetables may pose a risk to the human health.…”

Section: Introductionmentioning

confidence: 99%

Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

2018

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Background: Nowadays, the heavy metals pollution is increasing and the accumulation of these metals in food has posed adverse effects on humans such as inducing various kinds of cancer and non-cancer diseases. The Northeast of Iran, especially Torkman Sahra, has the maximum number of patients with esophageal cancer. Objectives: We investigated the levels of four heavy metals (Zn, Cd, Pb, and Cu) in cucumber and tomato samples in Golestan province, an endemic esophageal cancer region. We evaluated the levels and potential health risks of heavy metals in vegetable samples of Northeastern Iran. Methods: The heavy metal content of the samples was determined by polarography methods. All sample preparation and digestion procedures were carried out according to the Standard Methods for the Examination of Water and Wastewater, 20th Edition. Results:The results showed that Cd and Pb concentrations in cucumber and tomato were estimated to be respectively 2.4 to 14.4 and 1.6 to 7 folds higher whereas Zn and Cu levels were lower than the maximum permissible limit for vegetables. The amounts of Pb intake through the consumption of these vegetables were determined more than the provisional tolerable daily intake. The total non-cancer and cancer risk results indicated that the investigated region was relatively unsuitable for growing the vegetables in the view of the risk of the elevated intakes of heavy metals adversely affecting food safety for consumers. Pb was the heavy metal posing non-cancer risks while Cd caused the greatest cancer risk. Conclusions: It was concluded that due to the toxic effects of cadmium and lead, we should be more serious to reduce pollution levels in this region.

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Section: Introductionmentioning

confidence: 99%

Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

2018

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“…Cadmium contamination poses a serious health threat throughout the world, and cadmium has been classified as a human carcinogen by the International Agency for Research on Cancer (1994). Toxic responses to cadmium exposure include kidney damage, respiratory diseases, neurological disorders, and lung, kidney, prostate and testicular cancers (Abdulla and Chmielnicka, 1989;Waalkes, 2003).…”

Section: Introductionmentioning

confidence: 99%

p53-dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts

Cao

Zhou

Simpson

et al. 2007

Toxicology and Applied Pharmacology

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This study focused on the activation of cell cycle checkpoint responses in diploid human fibroblasts that were treated with cadmium chloride and the potential roles of ATM and p53 signaling pathways in cadmium-induced responses. The alkaline comet assay indicated that cadmium caused a dosedependent increase in DNA damage. Cells that were rendered p53-defective by expression of a dominant-negative p53 allele or knockdown of p53 mRNA were more resistant to cadmium-induced inactivation of colony formation than normal and ataxia telangiectasia (AT) cells. Synchronized fibroblasts in S were more sensitive to cadmium toxicity than cells in G1 suggesting that cadmium may target some element of DNA replication. Cadmium produced a dose-and time-dependent inhibition of DNA synthesis. An immediate inhibition was associated with severe delay in progression through S phase and a delayed inhibition seen 24 h after treatment was associated with accumulation of cells in G2. AT and normal cells displayed similar patterns of inhibition of DNA synthesis and G2 delay after treatment with cadmium, while p53-defective cells displayed significantly less of the delayed inhibition of DNA synthesis and accumulation in G2 post-treatment. Total p53 protein and ser15-phosphorylated p53 were induced by cadmium in normal and AT cells. The p53 transactivation target Gadd45α was induced in both p53-effective and p53-defective cells after 4 h cadmium treatment, and this was associated with an acute inhibition of mitosis. Cadmium produced a very unusual pattern of toxicity in human fibroblasts, inhibiting DNA replication and inducing p53-dependent growth arrest but without induction of p21 Cip1/Waf1 or activation of Chk1.

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“…Lead has been associated with intoxications leading to problems in the kidney and liver, the central nervous system, reproductive organs and anaemia (IOCCC, 1996). Although Copper is an essential trace element in the functions of the human body, chronic and excessive intake has been linked with digestive tract problems and cirrhosis of the liver (Oskarsson, 1989;Abdulla & Chmielnicka, 1990).…”

Section: Introductionmentioning

confidence: 99%

Copper and lead levels in two popular leafy vegetables grown around Morogoro Municipality, Tanzania

Chove

Ballegu

Chove

2006

Tanzania J Hlth Res

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Abstract:A study was carried out to determine the levels of two heavy metals, Lead (Pb) and Copper (Cu), in two popular leafy vegetables grown around Morogoro Municipality in Tanzania. Vegetable samples of Pumpkin leaves (Cucurbita moschata) and Chinese cabbage (Brassica chinensis) were collected from three sites and analysed for their concentrations of the two metals using an Atomic Absorption Spectrophotometer. The three sites, namely Mazimbu, Kihonda and Towelo are located within a 10 km perimeter. The site selection was based on the anticipated levels of contamination of the water used for irrigation. The results showed that the levels (mg/100g dry weight) ranged from 0.885 to1.39 for Copper and 0.05 to 0.315 for Lead. The levels of Lead and Copper varied between the vegetable varieties and from site to site. Vegetables from Mazimbu showed higher concentration levels of the two metals compared to the other sites in both varieties. Towelo vegetables had relatively low concentrations. There was a significant difference (P<0.05) in levels of the two metals across the sites but there was no significant difference (P>0.05) in the levels of Copper between the two vegetable varieties from all the three sites. There was a significant difference (P<0.05) in the levels of Lead between the vegetable varieties. The levels of both Lead and Copper in the two vegetables were found to be below the maximum permissible levels recommended by FAO/WHO for the two metals in vegetables.

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New aspects on the distribution and metabolism of essential trace elements after dietary exposure to toxic metals

Cited by 121 publications

References 119 publications

Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

p53-dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts

Copper and lead levels in two popular leafy vegetables grown around Morogoro Municipality, Tanzania

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