New atypical epidemiological profile of parvovirus B19 revealed by molecular screening of blood donations, France, winter 2023/24

Guillet, Marlène; Bas, Ariane; Lacoste, Marjorie; Ricard, Céline; Visse, Catherine; Barlet, Valérie; Malard, Lucile; Le Cam, Sophie; Morel, Pascal; de Lamballerie, Xavier; Laperche, Syria; Gallian, Pierre

doi:10.2807/1560-7917.es.2024.29.21.2400253

Cited by 7 publications

(1 citation statement)

References 16 publications

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“…While the number of deaths of children under 1 year of age (five deaths from January to May) in 2024 is based on non-exhaustive data, it highly exceeds the number between 0 and 1 in the previous 7 years (on exhaustive data). A recently published French study shows the same trend among B19V molecular screening in blood donors [ 9 ].…”

Section: Discussionmentioning

confidence: 65%

An unusual outbreak of parvovirus B19 infections, France, 2023 to 2024

d’Humières,

Fouillet,

Verdurme

et al. 2024

Eurosurveillance

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From April 2023 to May 2024, an unusual epidemic of parvovirus B19 (B19V) infections occurred in France. The number of B19V IgM-positive serologies was four times higher than in the previous epidemic in 2019. Clinical data from emergency networks corroborated this observation. Morbidity and mortality consequences were observed in children through all data sources. In adults, the increase was only observed in laboratory-confirmed data. Physicians and decisionmakers should be informed in order to better prevent, diagnose and manage at-risk patients.

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Section: Discussionmentioning

confidence: 65%

An unusual outbreak of parvovirus B19 infections, France, 2023 to 2024

d’Humières,

Fouillet,

Verdurme

et al. 2024

Eurosurveillance

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Unexpected high incidence of parvovirus B19 nucleic acid detection in German blood donors in the winter/spring season 2023/2024

Plümers,

Dreier,

Knabbe

et al. 2024

Journal of Medical Virology

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In healthy adults, parvovirus B19 (PVB19) typically causes mild symptoms but can lead to severe complications in immunosuppressed individuals or those with high red blood cell turnover. Infection can occur through respiratory transmission or via transfusion, necessitating the testing of blood donations in Germany. Between 2015 and April 2024, we screened 2 105 755 blood donations for PVB19 using polymerase chain reaction. Incidence rates were calculated for three periods: pre‐COVID‐19 (2015–2020), during the pandemic (2020–2023), and post‐COVID‐19 (2023–2024). A total of 242 PVB19‐positive donations were identified. In the first period, there were 101 positives out of 1 228 361 donations (incidence: 0.83/10 000). In the second period, four positives were found out of 621 222 donations (incidence: 0.06/10 000). In the third period, 137 positives were detected out of 235 088 donations (incidence: 5.35/10 000) with a striking increase of incidence between December 2023 and March 2024 (4.3–21.1/10 000 donations). Most people develop lifelong immunity after infection in childhood but the COVID‐19 pandemic interventions, like masks and distancing, correlate with a decline in PVB19 infections in donors indicating an impact of hygiene measures on PVB19 infection rates.

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Differential diagnosis on measles and rubella discarded cases highlights a sharp increase in parvovirus B19 infections in Milan, Northern Italy, in the first months of 2024

Fappani,

Gori,

Bianchi

et al. 2024

Journal of Medical Virology

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In line with European trends, since 2023 Lombardy (Northern Italy) is experiencing a resurgence of measles and an increased number of reported cases of fever and rash. Measles discarded cases observed in our region within the context of measles and rubella surveillance from the first few months of 2024 (N = 30) were investigated for parvovirus B19 (B19V) and other rash‐associated viruses. Thirteen cases tested positive for B19V DNA, representing a significant increase from previous years (on average 3 cases per year, p < 0.001) and ~40% of all B19V DNA‐positive patients we detected since 2017. In 2024, B19V DNA‐positive subjects spanned all ages, and the virus was predominant among adolescents and adults (84.6%). Two B19V infected patients were hospitalised, and likely cross‐reacting anti‐measles virus IgM were found in both. Our data align with the recent reports from the ECDC and various European countries, which are experiencing a surge in B19V infections, and underline the importance of comprehensive measles and rubella surveillance systems that can adapt to changing epidemiological trends.

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New atypical epidemiological profile of parvovirus B19 revealed by molecular screening of blood donations, France, winter 2023/24

Cited by 7 publications

References 16 publications

An unusual outbreak of parvovirus B19 infections, France, 2023 to 2024

An unusual outbreak of parvovirus B19 infections, France, 2023 to 2024

Unexpected high incidence of parvovirus B19 nucleic acid detection in German blood donors in the winter/spring season 2023/2024

Differential diagnosis on measles and rubella discarded cases highlights a sharp increase in parvovirus B19 infections in Milan, Northern Italy, in the first months of 2024

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