New benzylpiperazine derivatives bearing mono‐ and bis‐dialkyl substituted 1,2,4‐triazoles

Al‐Soud, Yaseen A.; Qalalweh, Mohammed N. A.; Al-Sa’doni, Haitham H.; Al‐Masoudi, Najim A.

doi:10.1002/hc.20061

Cited by 11 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[16] Alternatively, α,α -dichloroazo compounds e, prepared by chlorination of azines d, [17] have been used in preparation of the 1-aza-2-azoniallene salts with a more suitable leaving group (CClR 3 R 4 ) f ( Figure 1). This method included spontaneous rearrangements: the [1,2]-tert-butyl group migration followed by elimination processes.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of 1,2,4-TriazoleC-Nucleosides from Hydrazonyl Chlorides and Nitriles

Al‐Masoudi¹,

Al‐Soud²,

Ali³

2007

Nucleosides, Nucleotides and Nucleic Acids

Self Cite

View full text Add to dashboard Cite

A series of 1,3-diaryl-5-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole nucleosides (3a-f) were synthesized via the intermolecular cyclization of hydrazonyl chlorides with peracylated ribofuranosyl cyanide catalyzed by Yb(OTf)3 or AgNO3, respectively. Similarly, the 1,2,4-triazole of glucopyranosyl C-nucleosides 5a,b were prepared from the hydrazonyl chlorides and the nitrile 4. Alternatively, the 1,2,4-triazole N-nucleoside 8 was obtained from cyclization of the unsymmetrical bis[alpha-(4-methoxyphenyl)aminobenzylidene]-hydrazine with peracylated 1-amino-D-manno-pentitol.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis of 1,2,4-TriazoleC-Nucleosides from Hydrazonyl Chlorides and Nitriles

Al‐Masoudi¹,

Al‐Soud²,

Ali³

2007

Nucleosides, Nucleotides and Nucleic Acids

Self Cite

View full text Add to dashboard Cite

show abstract

“…Literature has reported that 1,3-dipolar cycloaddition as one type of pericyclic reactions relating to six electrons could perform a versatile and efficient one-pot reaction to access five-membered heterocycles [84][85][86][87][88][89] particularly triazole derivatives starting from available oximes, hydrazones and hydrazonoyl halides [90][91][92]. The 1,3-dipolar cycloaddition of phenyl substituted hydrazonoyl chloride 59 with oxime 60 in the presence of excess triethylamine could generate triazole derivative 61 with broad antimicrobial spectrum (Scheme 22).…”

Section: Other Hydrazonesmentioning

confidence: 99%

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

Zhang¹,

Damu²,

Cai³

et al. 2014

COC

View full text Add to dashboard Cite

Heterocyclic 1,2,4-triazole derivatives possess unusually spacious potentiality as medicinal agents, agricultural chemicals, functional materials, ionic liquids, supramolecular catalysts as well as artificial enzymes and receptors for supramolecular recognition and biomimetic catalysis, and their various researches and developments have been being a quite rapidly developing and active highlight topic with an infinite space. Numerous efforts have been directed toward various types of possible applications of 1,2,4-triazole-based compounds and a lot of important progress has been made, especially their preparations have attracted increasing attention. This review systematically summarized the recent advances in the syntheses of 1,2,4-triazole derivatives, including: (1) Cyclizations to form triazole ring; (2) Transformations of heterocyclic compounds to construct triazole ring; (3) Substitutions on 1,2,4-triazole ring; (4) Structural modifications in side chains of 1,2,4-triazole ring. It was hoped that this review would be helpful for the design and development of highly efficient preparation of 1,2,4-triazole derivatives with various sorts and varieties of extensively potential applications in medicine, agriculture, chemistry, materials, supramolecular sciences and so on.

show abstract

“…In addition, it was mentioned that [1,3,4]thiadiazoles exhibited various biological activities possibly due to the presence of the =N-C-S moiety [16]. In connection with our strategy in the synthesis of new amino acid derivatives [17][18][19], we report here the synthesis of new 1,2,4-triazolo-naphthalene and thiadiazole derivatives derived from amino acid analogues, and the evaluation of their anti-HIV activity.…”

Section: Introductionmentioning

confidence: 96%

Amino Acid Derivatives, Part 4: Synthesis and Anti‐HIV Activity of New Naphthalene Derivatives

Hamad

Al-Haidery

Al-Masoudi

et al. 2010

Archiv der Pharmazie

Self Cite

View full text Add to dashboard Cite

A new series of 2-(naphthalen-2-yloxy)-N-[(aryl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl] acetamides 5a-f was synthesized from naphthalene-derived glycine derivative 2 via the hydrazinoacetamide analogs 4a-f. Alternatively, treatment of 4a with H(2)SO(4) afforded 2-(naphthalen-2-yloxy)-N-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)methyl) acetamide 6a. Alkylation or sulphonylation of 5a afforded the S-alkylated derivatives 7 and 8, respectively. Interestingly, treatment of 3 with methoxide ion gave the triazine derivative 9. The synthesized compounds have been screened for their inhibitory activity against HIV-1 and HIV-2 in MT-4 cells. However, 7 was found to be the potent inhibitor in vitro for the replication of HIV-1 (EC(50 )= 0.20 microg/mL), suggesting a new lead in the development of an antiviral agent.

show abstract

New benzylpiperazine derivatives bearing mono‐ and bis‐dialkyl substituted 1,2,4‐triazoles

Cited by 11 publications

References 36 publications

Synthesis of 1,2,4-TriazoleC-Nucleosides from Hydrazonyl Chlorides and Nitriles

Synthesis of 1,2,4-TriazoleC-Nucleosides from Hydrazonyl Chlorides and Nitriles

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

Amino Acid Derivatives, Part 4: Synthesis and Anti‐HIV Activity of New Naphthalene Derivatives

Contact Info

Product

Resources

About