New Bicyclic Taxane Diterpenoids from Taxus sumatrana.

Abstract

Investigation of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2a a,7b b,13a a-triacetoxy-5a a,9a a-dihydroxy-2(3→20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1-and 2D NMR, and chemical derivatization.

Common toxidromes of plant poisonings in Taiwan

“…There were two deaths caused by Taxus sumatrana (Miq.) de Laub., which results in sinus bradycardia, premature ventricular contractions, atrioventricular conduction defects, or ventricular tachydysrhythmias (5,(35)(36)(37)(38). In the two Taxus fatalities, one died from hemolysis and multiple organ failure and the other from acute myocardial infarction.…”