New Bio-Based Cu(II) Complexes and Study of their Anti-Cancer Activities

Pulimamidi, Rabindra Reddy; Chandrashekar, Ravula; Satyanarayana, B.

doi:10.1007/s10895-016-1801-8

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…44) were prepared, and their interaction with the DNA was investigated. Previously, copper(II) complexes are reported to show a variety of biochemical activity in different areas like anticancer [83]. The dipeptides utilized in these compounds are (Gly-gly and Gly-L-leu) glycylglycine anion and glycyl-L-leucine anion respectively for compounds 1 and 2.…”

Section: Benzoxazole-metal Complexesmentioning

confidence: 99%

Anticancer activity of benzoxazole derivative (2015 onwards): a review

Ghoshal

Patel

2020

Futur J Pharm Sci

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Background According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Benzoxazole and its derivative represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with benzoxazole moiety have also shown to be potent towards cancer. Main text In the last few years, many research groups have designed and developed many novel compounds with benzoxazole as their backbone and checked their anticancer activity. In the review article, the recent developments (mostly after 2015) made in the direction of design and synthesis of new scaffolds with very potent anticancer activity are briefly described. The effect of various heterocycles attached to the benzoxazole and their effect on the anticancer activity are thoroughly studied and recorded in the review. Conclusion These compiled data in the article will surely update the scientific community with the recent development in this area and will provide direction for further research in this area.

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Section: Benzoxazole-metal Complexesmentioning

confidence: 99%

Anticancer activity of benzoxazole derivative (2015 onwards): a review

Ghoshal

Patel

2020

Futur J Pharm Sci

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Two New Mononuclear Copper(II)-Dipeptide Complexes of 2-(2′-Pyridyl)Benzoxazole: DNA Interaction, Antioxidation and in Vitro Cytotoxicity Studies

Gan

Xiong

et al. 2016

J Fluoresc

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Two new mononuclear mixed ligand copper(II) complexes [Cu(PBO)(Gly-gly)(HO)]·ClO·1.5HO (1) and [Cu(PBO)(Gly-L-leu)(HO)]·ClO (2) (PBO is 2-(2'-pyridyl)benzoxazole, Gly-gly and Gly-L-leu are Glycyl-glycine anion and Glycyl-L-leucine anion, respectively), have been prepared and characterized by various analytical and spectral techniques. The interactions of the complexes with DNA were investigated using multi-spectroscopic methods (absorption, emission, circular dichroism), viscometry and electrochemical titration as well as molecular docking technique. The results indicated that 1 and 2 are bound to calf thymus DNA (CT-DNA) through an intercalative mode. The thermodynamic analyses revealed that the reactions between the Cu(II) complexes with DNA are spontaneous with negative Gibbs free energy (ΔG). The positive changes of enthalpy (ΔH) and entropy (ΔS) suggested that the binding processes are dominated by hydrophobic interaction accompanying with endothermic. Also, the complexes exhibited efficient oxidative cleavage of pBR322 plasmid DNA in the presence of ascorbic acid, probably induced by •OH as reactive oxygen species. In addition, 1 and 2 displayed excellent antioxidant activities with the IC values of 0.112 and 0.191 μM, respectively, using the mean of nitroblue tetrazolium (NBT) photochemical reduction under a nonenzymatic condition. Moreover, the complexes were screened for their in vitro cytotoxicity against three human carcinoma cell lines (HeLa, PC-3 and A549), in which 2 owns higher cytotoxicity, which was consistent with DNA binding and cleavage ability order of the complexes. This results showed the in vitro biochemical potentials of the Cu(II)-dipeptide complexes with aromatic heterocyclic, viz. effective metallopeptide-nucleases, SOD mimics and non-platinum chemotherapeutic metallopharmaceuticals and their structure-activity relationship, which may contribute to the rational molecular design of new metallopeptide based chemotherapeutic agents.

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