New bioactive glass-ceramic: Synthesis and application in PMMA bone cement composites

Samad, H. A.; Jaafar, Mariatti; Othman, Radzali; Kawashita, Masakazu; Razak, Noor Hayati Abdul

doi:10.3233/bme-2011-0673

Cited by 27 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to fabricate the antifibrotic wound dressings, we have used PMMA as the electrospinning carrier with an efficient control of NF formation and drug encapsulation. PMMA is particularly interesting for this application as it is used extensively in orthopedic settings as a drug delivery vehicle for antibiotics because of its high biocompatibility and ease of manipulation . PMMA is a hydrophobic polymer; therefore, only a small percentage of the encapsulated drug is released from monolithic forms with low surface area to volume ratios .…”

Section: Resultsmentioning

confidence: 99%

“…PMMA is particularly interesting for this application as it is used extensively in orthopedic settings as a drug delivery vehicle for antibiotics because of its high biocompatibility and ease of manipulation. [40][41][42][43] PMMA is a hydrophobic polymer; therefore, only a small percentage of the encapsulated drug is released from monolithic forms with low surface area to volume ratios. [44][45][46][47][48] The release profiles may be modulated by the inclusion of water-soluble excipients 49 or increasing the surface area by using electrospinning.…”

Section: Fiber Formation and Characterizationmentioning

confidence: 99%

See 1 more Smart Citation

Development of a nanofibrous wound dressing with an antifibrogenic properties in vitro and in vivo model

Poormasjedi‐Meibod

Pakyari

Jackson

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

Dermal fibrosis, characterized by excessive extracellular matrix (ECM), is a pathological condition with limited effective therapeutic modalities. Lack of an antiscarring dressing further impedes the preventive measures for this condition. Here, we develop a new antiscarring dressing and investigate its potential as a slow-releasing vehicle for kynurenic acid (KynA), an antifibrotic agent. KynA was incorporated into polymethyl methacrylate (PMMA) nanofibers, containing increasing concentration of polyethylene glycol (PEG). Fibre morphology, water absorption capacity, surface hydrophilicity, in vitro drug release profile, and in vivo antifibrotic effects were investigated. Increasing concentrations of PEG (1-20%) significantly increased surface hydrophilicity, water absorption capacity, and drug release. Based on the obtained release profiles, PMMA + 10% PEG was the preferred formulation for sustained KynA release up to 120 hours. In vitro studies confirmed the preservation of KynA antifibrotic properties during electrospinning, indicated by fibroblasts proliferation suppression and ECM expression modulation. In vivo application of KynA-incorporated films significantly inhibited collagen (23.89 ± 4.79 vs. 6.99 ± 0.41, collagen-I/β-actin mRNA expression, control vs. treated) and fibronectin expression (7.18 ± 1.09 vs. 2.31 ± 0.05, fibronectin/β-actin mRNA expression, control vs. treated) and enhanced the production of an ECM-degrading enzyme (2.03 ± 0.88 vs. 11.88 ± 1.16 MMP-1/β-actin mRNA expression, control vs. treated). The fabricated KynA-incorporated films can be exploited as antifibrotic wound dressings. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2334-2344, 2016.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Fiber Formation and Characterizationmentioning

confidence: 99%

Development of a nanofibrous wound dressing with an antifibrogenic properties in vitro and in vivo model

Poormasjedi‐Meibod

Pakyari

Jackson

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…The optimal time required is between 10 and 15 min [33]. If the setting time is too long, the surgeon must wait until he/she can close the wound [34]. Tsukeoka et al developed a bioactive PMMA cement through modification with gmethacryloxypropyltrimethoxysilane and calcium acetate, but the bone cement had a setting time of 18 min [29], which was beyond the range of clinical demands.…”

Section: Discussionmentioning

confidence: 99%

Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding

Chen

Huang

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

BackgroundPolymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmethacrylate can be achieved with the addition of carboxymethylcellulose, alginate and gelatin microparticles to promote bone ingrowth, but the mechanical properties are too low to be used in orthopedic applications. Bone ingrowth into cement could decrease the possibility of bone resorption and promote the formation of a stable interface. However, scarce literature is reported on bioactive bone cements that allow bone ingrowth. In this paper, we reported a porous surface modified bioactive bone cement with desired mechanical properties, which could allow for bone ingrowth.Materials and MethodsThe porous surface modified bioactive bone cement was evaluated to determine its handling characteristics, mechanical properties and behavior in a simulated body fluid. The in vitro cellular responses of the samples were also investigated in terms of cell attachment, proliferation, and osteoblastic differentiation. Furthermore, bone ingrowth was examined in a rabbit femoral condyle defect model by using micro-CT imaging and histological analysis. The strength of the implant–bone interface was also investigated by push-out tests.ResultsThe modified bone cement with a low content of bioactive fillers resulted in proper handling characteristics and adequate mechanical properties, but slightly affected its bioactivity. Moreover, the degree of attachment, proliferation and osteogenic differentiation of preosteoblast cells was also increased. The results of the push-out test revealed that higher interfacial bonding strength was achieved with the modified bone cement because of the formation of the apatite layer and the osseointegration after implantation in the bony defect.ConclusionsOur findings suggested a new bioactive bone cement for prosthetic fixation in total joint replacement.

show abstract

“…For instance, composites of ceramics in PMMA have shown improved bioactivity, increased cell adhesion in vitro and reduction in the amount of heat released during the polymerisation as compared to PMMA alone. Moreover, PMMA composites with BAG, silicates, HA and TCP enhance the mechanical properties of PMMA in addition to its bioactivity [147][148][149][150][151][152][153][154][155][156]. HA and TCP incorporation significantly reduces the amount of heat generated during the polymerisation of PMMA and improve cell attachment [157][158][159].…”

Section: Polymeric Matrix Composite Materialsmentioning

confidence: 99%

“…PMMA/BAG composites have shown good bioactivity as well as enhanced mechanical strength [148,161,162]. For instance, composite of PMMA and silicate-based bioceramic showed good cell attachment, proper setting time and high mechanical strength as compared to PMMA alone [161].…”

Section: Polymeric Matrix Composite Materialsmentioning

confidence: 99%

3D printed composite materials for craniofacial implants: current concepts, challenges and future directions

Jindal

Manzoor

Haslam³

et al. 2020

Int J Adv Manuf Technol

View full text Add to dashboard Cite

Millions of craniofacial surgeries are performed annually worldwide for craniofacial bones’ replacement and augmentation. This represents a significant economic burden as well as aesthetic expectations. Autografts and allografts are the first choice for treatment of craniofacial defects; however, their limited availability and difficulty to shape have led to investigation for alternative strategies. Biomaterial-based approaches have been used for implantation as they have ample supply but their processing through conventional technologies present several drawbacks; the major one relates to the poor versatility towards the production of patient-specific implants. Additive manufacturing has gained considerable attention during the last decade, as it allows the manufacturing of implants according to patient need. Biomaterial implants can be additively manufactured but have one or more limitations of stress shielding, radiopacity, high strength to weight ratio and limited bone integration. Over the last few decades, composites are investigated to surmount the limitations with traditional implants and also improve their bone integration. This review provides an overview of the most recent polymeric composite-based biomaterials that have been used in combination with 3D printing technology for the development of patient-specific craniofacial implants. Starting with the conventional treatments, biomaterials available for the craniofacial implants, the additive manufacturing rationale are discussed. Also, the main challenges still associated with 3D printing of polymer-based composites are critically reviewed and the future perspective presented.

show abstract

New bioactive glass-ceramic: Synthesis and application in PMMA bone cement composites

Cited by 27 publications

References 24 publications

Development of a nanofibrous wound dressing with an antifibrogenic properties in vitro and in vivo model

Development of a nanofibrous wound dressing with an antifibrogenic properties in vitro and in vivo model

Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding

3D printed composite materials for craniofacial implants: current concepts, challenges and future directions

Contact Info

Product

Resources

About