New biological treatments for asthma and skin allergies

Eyerich, Stefanie; Metz, Martin; Bossios, Apostolos; Eyerich, Kilian

doi:10.1111/all.14027

Cited by 82 publications

(76 citation statements)

References 143 publications

(263 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Urticaria is a common skin disease, and various factors are known to be associated with the onset and/or the aggravation of urticaria. Recent development of biologics, such as omalizumab, humanized monoclonal antibody against IgE, have largely improved its treatment [38,39]. However, many patients still do not benefit from or tolerate such therapies, and the molecular mechanism of wheal formation in urticaria is poorly understood [1,2,5].…”

Section: Discussionmentioning

confidence: 99%

A single reaction-diffusion equation for the multifarious eruptions of urticaria

et al. 2020

View full text Add to dashboard Cite

Urticaria is a common skin disorder characterized by the rapid appearance and disappearance of local skin edema and flares with itching. It is characterized by various macroscopic skin eruptions unique to patients and/or subtypes of urticaria with respect to shape, size, color, and/or duration of eruptions. Nevertheless, the mechanism underlying multifarious eruptions in urticaria is largely unknown. The eruptions are believed to be evoked by histamine release from mast cells in the skin. However, the majority of visible characteristics of urticaria cannot be explained by a simple injection of histamine to the skin. To explain the multifarious eruptions of urticaria, we developed a single reaction-diffusion model suggesting the self-activation and self-inhibition regulation of histamine release from mast cells. Using the model, we found that various geometrical shapes of eruptions typically observed in patients can be explained by the model parameters and randomness or strength of the initial stimuli to mast cells. Furthermore, we verified that the wheal-expanding speed of urticaria, which is shown to be much smaller than that of the intradermal injection experimental system may be explained by our model and a simple diffusion equation. Our study suggests that the simple reaction-diffusion dynamics, including the independent self-activating and-inhibitory regulation of histamine release, may account for the essential mechanism underlying the formation of multifarious eruptions in urticaria.

show abstract

Section: Discussionmentioning

confidence: 99%

A single reaction-diffusion equation for the multifarious eruptions of urticaria

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Antihistamines, which are frequently used in the treatment of AD, have the effect of suppressing histamine secreted from cells, such as mast cells, and thereby suppress itching. [41,42] In addition, it has recently been reported that mast cells are also involved in the pathogenesis of AA. [43][44][45] For example, the mast cell density was significantly increased in the HF mesenchyme and surrounding perifollicular dermis of AA lesions when compared to healthy control skin.…”

Section: Ma S T Cell S In a A And Admentioning

confidence: 99%

Understanding the significance of cytokines and chemokines in the pathogenesis of alopecia areata

Ito

Kageyama

Nakazawa

et al. 2020

Experimental Dermatology

View full text Add to dashboard Cite

Alopecia areata has basically been understood as a type 1 inflammatory disease. Activated NKG2D+CD8+ cells produce the Th1 cytokine interferon‐γ, which leads to the disruption of immune tolerance of hair follicles and the exposure of self‐antigens. This results in dense inflammatory cell infiltration and apoptosis around hair follicles, inducing hair loss. A well‐known complication of alopecia areata is atopic dermatitis, a typical type 2 inflammatory disease. Hair scientists have shied away from confronting and understanding how alopecia areata, a type 1 inflammatory disease, and atopic dermatitis, a type 2 inflammatory disease, can occur together. This review summarizes the research on the cytokine balance in alopecia areata and then focuses on the classification of the cytokine balance in alopecia areata, including the classification of atopic dermatitis into extrinsic and intrinsic types. Dupilumab reportedly showed dual efficacy in a patient with concomitant atopic dermatitis and alopecia areata, supporting our own experience. Elevated Th2 cytokine levels have also been reported in patients with alopecia areata, with increased serum IL‐4, IL‐5, IL‐6 levels, high IgE levels and elevated eosinophil levels. Because local immunotherapy is a treatment that induces Th2‐type inflammation, it may worsen the condition of alopecia areata patients with extrinsic atopic dermatitis. It is desirable to select appropriate treatments with consideration of the cytokine balance.

show abstract

“…IL-4 and IL-13 are key cytokines in driving the initiation and chronicity of type 2 (T2) inflammation, a dominant inflammatory pathway in AD (11,12). Dupilumab is a fully human anti-IL-4 receptor α (IL-4Rα) monoclonal antibody that blocks both IL-4-and IL-13-mediated signalling pathways (13,14). The European Medical Agency (EMA) recommends dupilumab for moderate-to-severe AD in adult and adolescents (12 years and older) patients who are candidates for systemic therapy (15).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of dupilumab for moderate-to-severe atopic dermatitis: a systematic review for the EAACI Biologicals Guidelines

Agache¹,

Song²,

Posso³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

New biological treatments for asthma and skin allergies

Cited by 82 publications

References 143 publications

A single reaction-diffusion equation for the multifarious eruptions of urticaria

A single reaction-diffusion equation for the multifarious eruptions of urticaria

Understanding the significance of cytokines and chemokines in the pathogenesis of alopecia areata

Efficacy and safety of dupilumab for moderate-to-severe atopic dermatitis: a systematic review for the EAACI Biologicals Guidelines

Contact Info

Product

Resources

About