New Biologically Active Metabolites from Chinese Higher Fungi

Gao, Jin‐Ming

doi:10.2174/138527206776894393

Cited by 43 publications

(3 citation statements)

References 66 publications

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“…In 2023, the crude extract of S. commune was approved as a cosmetic ingredient for use as a skin moisturizer and protectant [ 5 ], wherein the exopolysaccharide plays a crucial role, by the China National Regulatory Commission. Unlike macromolecules in higher fungi, the potential applications of small molecules remain a mystery [ 6 , 7 , 8 ]. Currently, according to available bioinformatics data, this extremophilic fungus is known to encode at least 19 biosynthetic gene clusters, including those related to terpenes, non-ribosomal peptide synthetases (NRPSs), etc.…”

Section: Introductionmentioning

confidence: 99%

Combining the Elicitor Up-Regulated Production of Unusual Linear Diterpene-Derived Variants for an In-Depth Assessment of the Application Value and Risk of the Medicinal and Edible Basidiomycete Schizophyllum commune

Wang,

Cao,

Zhou

et al. 2024

Molecules

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To better assess the practical value and avoid potential risks of the traditionally medicinal and edible basidiomycete Schizophyllum commune, which may arise from undescribed metabolites, a combination of elicitors was introduced for the first time to discover products from cryptic and low-expressed gene clusters under laboratory cultivation. Treating S. commune NJFU21 with the combination of five elicitors led to the upregulated production of a class of unusual linear diterpene-derived variants, including eleven new ones (1–11), along with three known ones (12–14). The structures and stereochemistry were determined by 1D and 2D NMR, HRESIMS, ECD, OR and VCD calculations. Notably, the elongation terminus of all the diterpenes was decorated by an unusual butenedioic acid moiety. Compound 1 was a rare monocyclic diterpene, while 2–6 possessed a tetrahydrofuran moiety. The truncated metabolites 4, 5 and 13 belong to the trinorditerpenes. All the diterpenes displayed approximately 70% scavenging of hydroxyl radicals at 50 μM and null cytotoxic activity at 10 μM. In addition, compound 1 exhibited potent antifungal activity against the plant pathogenic fungi Colletotrichum camelliae, with MIC values of 8 μg/mL. Our findings indicated that this class of diterpenes could provide valuable protectants for cosmetic ingredients and the lead compounds for agricultural fungicide development.

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Section: Introductionmentioning

confidence: 99%

Combining the Elicitor Up-Regulated Production of Unusual Linear Diterpene-Derived Variants for an In-Depth Assessment of the Application Value and Risk of the Medicinal and Edible Basidiomycete Schizophyllum commune

Wang,

Cao,

Zhou

et al. 2024

Molecules

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“…The crude protein content of mushrooms varied from 12 to 35% dry weight depending upon the species. The free amino acids composition differs widely but in general they are rich in theronine and valine but deficient in sulfur containing amino acids (Methionine and cysteine) [2].…”

Section: Introductionmentioning

confidence: 99%

Screening and Potential Uses of Contaminated Spent Mushroom (Pleurotusspp.)

Shanmugavelu¹,

Sevugaperumal²

2021

Emerging Contaminants

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The commercial production of mushrooms generates a co-product, a virtually inexhaustible supply of spent mushroom substrate (SMS). It represents an ideal growth medium for plants and plant disease suppressive quality. Here we discussed about the contaminated microbial flora of SMS, potential antifungal and plant growth promoting activities, the results of these findings were also discussed in relation to the usage of SMS as a potential product for organic farming. SMS contained moisture content 72%, EC 1.75 mmho.cm−1 and had pH of 6.1. The cellulose and hemicellulose content of paddy straw substrate were 30.25%, 23.18% and 15.31% dry weight respectively. Growth in terms of root and shoot weight of the seedlings of green gram, black gram, tomato and chili were significantly higher when grown in 60% SMS amended soil. Spent mushroom compost from Pleurotus eous used in this study harbored bacterial population including, Bacillus sp., Clostridium sp., Pseudomonas sp. and E. coli. Bacterial isolate B1 was identified as Bacillus sp., isolate B2 was identified as Clostridium sp., isolate B3 as Pseudomonas sp. and B4 as Escherichia coli. These bacterial strains showed significant antagonistic activity against soil borne pathogenic fungi viz., Fusarium sp., Alternaria sp., Phytophthora sp. and Aspergillus sp.

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“…Fungi are abundant sources of secondary metabolites with distinct structures and a broad range of intriguing biological activities [1,2,3,4]. The genus Aspergillus (Moniliaceae), with over 180 species, has attracted considerable attention as a rich source of alkaloids, terpenoids, xanthones, steroids, and polyketides, some of which showed antimicrobial, antifouling, antifeedant, phytotoxic, or other interesting bioactivities [5,6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus

et al. 2014

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Abstract:Six sesquiterpenoids 1-6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A-D 3-6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO).

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New Biologically Active Metabolites from Chinese Higher Fungi

Cited by 43 publications

References 66 publications

Combining the Elicitor Up-Regulated Production of Unusual Linear Diterpene-Derived Variants for an In-Depth Assessment of the Application Value and Risk of the Medicinal and Edible Basidiomycete Schizophyllum commune

Combining the Elicitor Up-Regulated Production of Unusual Linear Diterpene-Derived Variants for an In-Depth Assessment of the Application Value and Risk of the Medicinal and Edible Basidiomycete Schizophyllum commune

Screening and Potential Uses of Contaminated Spent Mushroom (Pleurotusspp.)

Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus

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