2004
DOI: 10.1021/np0304722
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New Biologically Active Triterpenoid Saponins from Scabiosa tschiliensis

Abstract: Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7, 9), h… Show more

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Cited by 90 publications
(80 citation statements)
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“…S. tschiliensis flowers are traditionally used as a remedy for headache, fever, cough, and jaundice. 87 In vitro studies have reported that scabiosaponins E, F, G and I, hookeroside A and B, and prosapogenin 1b inhibit HPL. Of these, prosapogenin 1b reportedly possesses the greater inhibitory activity at a concentration of 0.12 mg/mL.…”
Section: Scabiosaponinsmentioning
confidence: 99%
See 1 more Smart Citation
“…S. tschiliensis flowers are traditionally used as a remedy for headache, fever, cough, and jaundice. 87 In vitro studies have reported that scabiosaponins E, F, G and I, hookeroside A and B, and prosapogenin 1b inhibit HPL. Of these, prosapogenin 1b reportedly possesses the greater inhibitory activity at a concentration of 0.12 mg/mL.…”
Section: Scabiosaponinsmentioning
confidence: 99%
“…This dose produced lipase inhibitory activity comparable to 0.005 mg/mL of orlistat in the same model. 87 The fact that to date no studies in vivo have been reported could be due to the difficulties in isolating these compounds. However, recently scabiosaponins E, F, and G have been successfully synthesized.…”
Section: Scabiosaponinsmentioning
confidence: 99%
“…In the HMBC experiments, the anomeric proton signals at In regard to the chemical constituents of N. damascena, alkaloid, 1) sesquiterpenes, 2) and phenolic compounds 3) have been characterized from the seeds, but no report on the aerial parts (leaves and stems) has been published to date. To our knowledge, these triterpene glycosides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) are first isolated from N. damascena. Meanwhile, a sugar sequence of 3- 13) and Scabiosa tschiliensis (Dipsacaceae), 11) respectively.…”
Section: And Hederagenin 3-o-a-lrhamnopyranosyl-(1→2)-a-l-arabinopyramentioning
confidence: 99%
“…To our knowledge, these triterpene glycosides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) are first isolated from N. damascena. Meanwhile, a sugar sequence of 3- 13) and Scabiosa tschiliensis (Dipsacaceae), 11) respectively. These saccharide moiety containing D-xylose are rare sugar sequence.…”
Section: And Hederagenin 3-o-a-lrhamnopyranosyl-(1→2)-a-l-arabinopyramentioning
confidence: 99%
“…The success of orlistat encouraged the development of PL inhibitors as weight-reducing drugs. In new weight-reducing therapies with more potency or fewer side effects, several natural PL inhibitors, such as platycodin saponins, scabiosaponins, chikusetsusaponins, tea saponins, assamicain A, oolonghomobisflavan A, and oolonghomobisflavan B, have been identified as inhibitors of PL activity in vitro (de la Garza et al, 2011;Han et al, 1999Han et al, ,2005Roh & Jung, 2012;Slanc et al, 2009;Zhao & Kim, 2004;Zheng et al, 2004). However, the compounds are difficult to develop as antiobesity drugs because of limited sources.…”
Section: Introductionmentioning
confidence: 99%