New Biphasic Calcium Phosphate in Orthopedic Surgery: First Clinical Results

Petronis, Sandris; Petronis, Jānis; Zālīte, Vita; Ločs, Jānis; Skaģers, Andrejs; Pilmane, Māra

doi:10.1007/978-3-642-34197-7_46

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…The BCP ceramic granules were prepared with nanopore sizes around 200 nm, packed into 10 g packs and sterilized. First results of BCP ceramic granules with HAp/β-TCP ratio of 90/10 as bone substitute for reconstruction of the bone defects in orthopedic surgery, such as fracture and fracture non-union treatment, primary and revision arthroplasty, and chronic osteomyelitis, were evaluated [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…We developed a method for filling femoral bone defects in non-cemented hip arthroplasty revisions and periprosthetic fractures, producing biphasic calcium phosphate (BCP) ceramic granules with hydroxyapatite/β-TCP (HAp/β-TCP) in selected ratio of 90/10, because minor amount of β-TCP due to the faster resorption rate compared to HAp is supposed to burst of releasing calcium and phosphate ions into biological medium, thus contributing new bone formation. The majority of HAp remaining after resorption of β-TCP acts as a tissue scaffold for the complete formation of new bone [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Filling Bone Defects after Hip Arthroplasty Revision Using Hydroxyapatite/?-tricalcium Phosphate: A Case Report with Long-term Result

Petronis

Jakušonoka

Linovs³

et al. 2021

JOCR

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Introduction: The increasing number of primary total hip replacements means that there is an increased need for hip arthroplasty revisions. The periprosthetic fractures which cause bone defects can occur during removal of the femoral component and healing of these fractures can be delayed. In femoral bone defects during revisions, there are no metal augments for filling these defects. Case Report: Fifty-nine-year-old female presented with infected loosening of the left hip non-cemented endoprosthesis 5 years after surgery. The patient underwent removal of endoprosthesis. In 2 months, re-implantation of non-cemented endoprosthesis was performed and biphasic calcium phosphate (BCP) ceramic granules with hydroxyapatite/?-tricalcium phosphate (HAp/?-TCP) were implanted in the femoral bone defects. Eleven months following the arthroplasty patient had periprosthetic fracture of the distal third of the left femur. The osteosynthesis was performed and BCP ceramic granules with HAp/?-TCP were used to fill the bone defect. Long-term follow-up showed very good functional outcome and bone defect healing. Conclusion: The BCP ceramic granules with HAp/?-TCP material adjusted to the bone defect anatomy, showed effective femoral bone defect and periprosthetic fracture healing in a patient with hip arthroplasty revision and periprosthetic fracture. Keywords: Bone defect, femoral, revision.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Filling Bone Defects after Hip Arthroplasty Revision Using Hydroxyapatite/?-tricalcium Phosphate: A Case Report with Long-term Result

Petronis

Jakušonoka

Linovs³

et al. 2021

JOCR

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“…This study investigated the efficacy of biphasic calcium phosphate bioceramics in orthograde filling of periapical lesion. It is known that BCP bioceramics is utilized in dental implantology, maxillofacial reconstructive procedures, periodontology, orbital implants, traumatology and to repair various types of bone defects [7][8]. Several bone substitutes are proposed for filling periapical lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Synthetic biomaterials based on biphasic calcium phosphate (BCP) bioceramics appeared in the market relatively recent. They are used in sinus lifting operations, in implantology, and in bone fractures and osteomyelitis repair [7][8][9]. Being biocompatible and sterile, they are completely devoid of antigenic properties, as well as threats of infection of the patient with dangerous infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Radiological Evaluation of Endodontic Treatment of Chronic Apical Periodontitis using Biphasic Calcium Phosphate Biomaterial

Курманалина¹,

Uraz²,

Skaģers³

et al. 2018

Eurasian J Anal Chem

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The article is dedicated to the study of the efficacy of the periapical therapy of chronic periodontitis with the use of synthetic calcium-phosphate biomaterial. 30 patients aged from 22 to 56 years participated in a clinical study. Radiological evaluation was performed by radiovisiography and radiodensitometry. Follow-up examination was carried out at 3, 6 and 12 months. Densitometry indicators at the destruction site showed an increase in radiodensity from 74.2 ± 9.9 units (58.2%) to 111.9 ± 10.6 units (87.8%) after 12 months. Anterior group of teeth demonstrated statistically significant high rate of lesion compaction compared to posterior teeth.

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“…CaP was synthesized by an aqueous precipitation technique from calcium hydroxide and phosphoric acid [10]. BCP granules in size range from 1.0 to 1.4 mm were prepared and characterized as described before [11]. Briefly, crystalline phase of CaP were analyzed by X-ray diffraction (XRD, PANalytical X'Pert Pro).…”

Section: Experimental Methodsmentioning

confidence: 99%

Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization <i>In Vivo</i> Six Months after Implantation

Petronis

Ločs

Zālīte

et al. 2016

KEM

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Calcium bone substitutes are successfully used for local recovery of osteoporotic bone and filling of bone defects. Previous studies revieled that biphasic calcium phosphate (BCP) show better bioactivity in compare to pure β-tricalcium phosphate or hydroxyapatite. Also increased porosity of material promotes better bone tissue response. Aim of this experiment was to evaluate immunohistologically response of osteoporotic bone of experimental animal to implantation of granules with hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) ratio of 90/10. Calcium phosphate (CaP) was synthesized by aqueous precipitation technique from calcium hydroxide and phosphoric acid. Bioceramic granules in size range from 1.0 to 1.4 mm were prepared with nanopore sizes around 200 nm. We used nine female rabbits with induced osteoporosis in this experiment. Six animals in study group underwent implantation of BCP in hip bone defect and three animals in control group left without BCP implantation. After 6 months animals were euthanized, bone samples collected and proceeded for detection of bone activity and repair markers: osteocalcin (OC), osteopontin (OP) and osteoprotegerin (OPG). Controls showed the presence of experimental bone osteoporosis. In experimental group bone showed partially resorbed bioceramic granules and in some samples new bone formation near the granuli was observed. Increase of OC and OPG up to twice as to compare to control group were detected as well. Implantation of BCP granules in osteoporotic rabbit bone increases expression of OC and OPG indicating the activation of osteoblastogenesis and bone mineralization in vivo.

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New Biphasic Calcium Phosphate in Orthopedic Surgery: First Clinical Results

Cited by 7 publications

References 3 publications

Filling Bone Defects after Hip Arthroplasty Revision Using Hydroxyapatite/?-tricalcium Phosphate: A Case Report with Long-term Result

Filling Bone Defects after Hip Arthroplasty Revision Using Hydroxyapatite/?-tricalcium Phosphate: A Case Report with Long-term Result

Radiological Evaluation of Endodontic Treatment of Chronic Apical Periodontitis using Biphasic Calcium Phosphate Biomaterial

Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization <i>In Vivo</i> Six Months after Implantation

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