New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants

Effect of Arylazo Sulfones on DNA: Binding, Cleavage, Photocleavage, Molecular Docking Studies and Interaction with A375 Melanoma and Non-Cancer Cells

“…Although most DNA-cleaving compounds are metal complexes, a significant number of research publications are devoted to organic molecules, also referred to as artificial "metalfree nucleases", aiming to identify differentiated mechanisms of action. Such compounds exhibit very diversified molecular structures, including, among the recent ones, simple oximes and hydroxylamines [5], coumarin oxime ethers [6], imidazo-phenanthrolines [7] and their carbohydrate conjugates [8], indolo-pyrimidines [9], pyridine [10] and naphthoquinone thiazole hybrids [11] and benzothiazole derivatives [12,13], bis-and tetrakis-1,2,3-triazole derivatives [14], naphthalenophanes [15], selenylated oxadiazoles [16], 2styryl-4-aminoquinazoline [17], calixarene-benzazole [18] and indolyl derivatives [19], azaenedienes [20], and the natural product Shishjimicin A [21].…”

Synthesis and Characterization of Few New Substituted 1,3,4-Oxadiazoles 1,2,4-Triazoles and Schiff Bases via Chalcone Compounds

“…6 Nowadays, the importance of triazoles and its derivatives comes from using this moiety in the design and synthesis of new compounds. 7 They are also considered an important molecule in bioactive synthesis linked to many biological activities. 8 Oxadiazol is a five-membered ring heterocyclic compound consisting of three atoms (two atoms of nitrogen with one atom of oxygen).…”

“…This established the first evidence for the successful synthesis of the targeted compound. Thioether compound (7) was synthesized by treating of compound (6) with benzyl bromide in 20% solution of sodium hydroxide in methanol, again the structure was proven by 1 H-NMR which showed a signal δ 4.30 ppm belongs to the benzylic protons. Substituted 1,2,4-triazole compound (8) was obtained via the cyclization of compound (5) in the presence of hydrazine hydrate and absolute ethanol.…”

“…Spectral data of synthesized compounds(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). evaluation of Schiff bases of 4-amino-1, 2, 4-triazole derivatives as potent angiotensin converting enzyme inhibitors and antioxidant activities.Journal of Molecular Structure, 1180, 344-354.…”

Trifluoromethylated Amidrazone Derivatives as Key Compounds for the Synthesis of 4-Aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles

“…Triazole scaffolds are very interesting in medicinal chemistry and to organic chemists in recent years due to their unique biological activities, 1 such as antimicrobial, 2 antioxidant, 3 anticancer, 4 antiviral, 5 anti-inflammatory, 6 antitubercular, 7 antihypertensive, 8 antiurease, 9 anticonvulsants, 10 antidiabetic, 11 and antidepressant. 12 Among these compounds, 1,2,4-triazoles are considered to be more remarkable isomers in pharmacology, because of their synthetic utility and wide spectrum of biological activities.…”