New capabilities of optical coherence tomography in the diagnostics of primary angle-closure glaucoma

Еричев, В. П.; Poleva, R.P.; Hadiri, Kh.

doi:10.53432/2078-4104-2021-20-2-14-22

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…In terminal uncompensated glaucoma vitreous syneresis and posterior detachment of vitreous body (PVD) is usually observed. In angle closure glaucoma the presence of PVD is associated with higher IOP than if it is absent [72]. At terminal stages of glaucoma there is dilation of optic nerve para-sheath spaces (personal observation).…”

Section: Figure 3 Calculation Elements Of Pressure Gradients and Prob...mentioning

confidence: 98%

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Beisekeeva¹,

Kulumbetova²,

Beisekeev³

et al. 2022

IJOVS

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The paper describes a novel theory of primary glaucoma etiopathogenesis based on a new understanding of the glymphatic system of the eye. Glymphatic flow routes of the eye include the vitreous body, uveal tract, paravascular spaces, and the retina. There are different pressure gradients of the intraocular fluid flow within the divided central channel of the vitreous body. In normal conditions above the foveola there is highly positive pressure gradient whereas above the optic disc it is 3 times lower. The retinal pigment epithelium is responsible for water and metabolic exchanges between choroid and the vitreous, therefore may contribute to intra-ocular fluid accumulation. Impairment of the outer blood-ocular and/or bloodaqueous barriers is the key pathogenic element of glaucoma including secondary forms due to uveitis. A disbalance of the pressure gradients above the macula and above the optic disc leads to fluid accumulation above the latter. An abundant intraretinal fluid flow through the glymphatic pathways in the outer and inner plexiform layers, formed by Muller cell processes, contributes to accumulation of the interstitial fluid before the lamina cribrosa. Excessive interstitial fluid from the retina passes not only through the retinal pigment epithelium to choroid but also through paravascular spaces to the optic disc cup and discharges partly back to the vitreous body through the prevascular vitreous fissures. There is an interstitial fluid flow existing through paravascular spaces, the plexiform layers of retina and along the axons of ganglion cells to the optic nerve and its sheath where excessive fluid is absorbed into the subarachnoid space. The RPE plays a major role in glaucoma etiopahogenesis, probably acting as a regulator of fluid transport in the eye.

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Section: Figure 3 Calculation Elements Of Pressure Gradients and Prob...mentioning

confidence: 98%

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Beisekeeva¹,

Kulumbetova²,

Beisekeev³

et al. 2022

IJOVS

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“…However, there is still no evidence in favor of any of the devices used not received yet. Regarding the available studies, most of them have criteria diagnoses of glaucoma are based on perimetric data, but recently the emphasis in the assessment glaucomatous damage shifts towards progressive changes in the optic disc [2,3]. The problem of timely and accurate differentiation between norm and pathology in diagnosis of primary open-angle glaucoma (POAG) along with obvious the need to determine traces of even minimal disease progression are a priority in modern glaucomatology [1][2][3][4].…”

mentioning

confidence: 99%

“…Minimizing the risk of decreased visual function is determined by a comprehensive approach, including, in particular, accurate determination of the stage of the disease, assessment life expectancy and rate of disease progression per based on the state of the optic disc, RNFL, visual fields [1,3]. For this reason, in the absence visual field defects, missing episodes of elevated IOP levels, researchers can miss both the onset of the disease and the opportunity to evaluate the dynamics of the process in the future, which will directly affect the duration of the disease, namely the time during which will lead to blindness.…”

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confidence: 99%

Modern Methods for Diagnostics of Glaucoma

Maribzhanovna,

Khoshimovna,

Maribzhanovich

et al. 2024

tajmspr

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Glaucoma is a chronic optical neuropathy characterized by loss of ganglion cells with the development of specific changes in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL). Early detection of the disease plays an important role in preventing the development structural abnormalities and irreversible vision loss. Diagnosis of glaucoma is based on assessing the safety of optic nerve structures and visual functions results clinical examination of the optic disc and RNFL are subjective and vary greatly. In connection with this, research in recent years has been aimed at developing additional objective methods for diagnosing glaucoma. The possibility of using confocal scanning laser ophthalmoscopy, scanning laser perimetry and optical coherence tomography to assess the condition of the optic disc. In order to ensure early detection of visual field defects options are currently being considered replacing standard automated perimetry (SAP) with selective, which includes short-wavelength automated perimetry (SWAP) and perimetry with the illusion of spatial doubling frequencies (frequency-doubling technology perimetry, FDT). The article is an overview modern method for diagnosing glaucoma in the context of their use in clinical practice.

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Features of cataract surgery and the postoperative period in patients with glaucoma (part 2)

Ivachev

2022

Glaucoma

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According to the results of various studies, in up to 50% cases after cataract phacoemulsification patients with glaucoma experience ophthalmic hypertension on the first day. This occurs due to the mechanical retention of aqueous humor in the anterior chamber. Temporary decrease in the function of the eye drainage system is explained by pigment particles, viscoelastic, erythrocytes, protein cells, product of postoperative inflammation and lens particles obstructing the trabecula. In the long-term period after phacoemulsification in glaucoma patients there is a decrease in the intraocular pressure in up to 74% of cases.A decrease in the density of endothelial cells in these patients occurs as a result of fluctuation of intraocular pressure, prolonged application of hypotensive drops, surgical intervention and presence of drainage devices after antiglaucoma surgery. This leads to the increase of inflammatory reaction of the cornea in the form of edema of up to 16.9% after cataract phacoemulsification.Phacoemulsification also provides a significant hypotensive effect (up to 34%) and is a preventive measure for an acute attack in patients with angle-closure glaucoma. However, the state of acute glaucoma attack leads to difficulties in phacoemulsification in the form of high intraocular pressure, corneal edema and small chamber. Cataract extraction under such circumstances causes an increase in postoperative corneal edema and eye inflammation of up to 22.85%.

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New capabilities of optical coherence tomography in the diagnostics of primary angle-closure glaucoma

Cited by 3 publications

References 3 publications

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Modern Methods for Diagnostics of Glaucoma

Features of cataract surgery and the postoperative period in patients with glaucoma (part 2)

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